American Journal of Physiology - Endocrinology and Metabolism
SCIE-ISI SCOPUS (1980-2023)
0193-1849
1522-1555
Mỹ
Cơ quản chủ quản: AMER PHYSIOLOGICAL SOC , American Physiological Society
Lĩnh vực:
Physiology (medical)PhysiologyEndocrinology, Diabetes and Metabolism
Các bài báo tiêu biểu
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance Adipose tissue expresses tumor necrosis factor (TNF) and interleukin (IL)-6, which may cause obesity-related insulin resistance. We measured TNF and IL-6 expression in the adipose tissue of 50 lean and obese subjects without diabetes. Insulin sensitivity (SI ) was determined by an intravenous glucose tolerance test with minimal-model analysis. When lean [body mass inde... ... hiện toàn bộ
Tập 280 Số 5 - Trang E745-E751 - 2001
Unexpected evidence for active brown adipose tissue in adult humansThe contention that brown adipose tissue is absent in adult man has meant that processes attributed to active brown adipose tissue in experimental animals (mainly rodents), i.e., classical nonshivering thermogenesis, adaptive adrenergic thermogenesis, diet-induced thermogenesis, and antiobesity, should be either absent or attributed to alternative (unknown) mechanisms in man. However, sere... ... hiện toàn bộ
Tập 293 Số 2 - Trang E444-E452 - 2007
Phép cộng hưởng từ quang phổ để đo lượng triglyceride trong gan: tỷ lệ phổ biến của tình trạng nhiễm mỡ gan trong dân số nói chung Dịch bởi AI Bất chấp sự gia tăng tỷ lệ bệnh gan nhiễm mỡ không do rượu (NAFLD), các tiêu chí được sử dụng để chẩn đoán bệnh vẫn chưa được xác định rõ ràng. Quang phổ cộng hưởng từ proton định vị (MRS) đo chính xác hàm lượng triglyceride gan (HTGC) nhưng chỉ được sử dụng trong một số nghiên cứu nhỏ. Trong nghiên cứu này, MRS đã được sử dụng để phân tích sự phân bố của HTGC ở 2,349 người tham gia nghiên... ... hiện toàn bộ
Tập 288 Số 2 - Trang E462-E468 - 2005
#gan nhiễm mỡ không do rượu #quang phổ cộng hưởng từ #triglyceride gan #tỷ lệ phổ biến #dân số đô thị #yếu tố nguy cơ #bệnh gan
Quantitative estimation of insulin sensitivity. We have evaluated the feasibility of using a mathematical model of glucose disappearance to estimate insulin sensitivity. Glucose was injected into conscious dogs at 100, 200, or 300 mg/kg. The measured time course of insulin was regarded as the "input," and the falling glucose concentration as the "output" of the physiological system storing and using glucose. Seven mathematical models o... ... hiện toàn bộ
Tập 236 Số 6 - Trang E667 - 1979
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humansThe purpose of the present study was to test the hypothesis that a transient increase in plasma IL-6 induces an anti-inflammatory environment in humans. Therefore, young healthy volunteers received a low dose of recombinant human (rh)IL-6 or saline for 3 h. Plasma IL-6 levels during rhIL-6 infusion were ∼140 pg/ml, corresponding to the levels obtained during strenuous exercise. The infusio... ... hiện toàn bộ
Tập 285 Số 2 - Trang E433-E437 - 2003
AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetesAdenosine 5′-monophosphate-activated protein kinase (AMPK) now appears to be a metabolic master switch, phosphorylating key target proteins that control flux through metabolic pathways of hepatic ketogenesis, cholesterol synthesis, lipogenesis, and triglyceride synthesis, adipocyte lipolysis, and skeletal muscle fatty acid oxidation. Recent evidence also implicates AMPK as being responsibl... ... hiện toàn bộ
Tập 277 Số 1 - Trang E1-E10 - 1999
Noninvasive determination of local cerebral metabolic rate of glucose in manA method for the determination of local cerebral metabolic rates of glucose (LCMRGlc) in normal man is described. The method employs [18F]2-fluoro-2-deoxy-D-glucose (FDG) and emission-computed tomography (ECT). FDG was injected intravenously as a bolus. Radioactivities in separate brain regions were measured with ECT. Plasma FDG concentration following injection was measured from blood sam... ... hiện toàn bộ
Tập 238 Số 1 - Trang E69-E82 - 1980
IRS proteins and the common path to diabetesAlthough a full understanding of insulin/insulin-like growth factor (IGF) action is evolving, the discovery of insulin receptor substrate (IRS) proteins and their role to link cell surface receptors to the intracellular signaling cascades provided an important step forward. Moreover, Insulin/IGF receptors use common signaling pathways to accomplish many tasks, the IRS proteins add a unique... ... hiện toàn bộ
Tập 283 Số 3 - Trang E413-E422 - 2002
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly This study was designed to evaluate the effects of enriching an essential amino acid (EAA) mixture with leucine on muscle protein metabolism in elderly and young individuals. Four (2 elderly and 2 young) groups were studied before and after ingestion of 6.7 g of EAAs. EAAs were based on the composition of whey protein [26% leucine (26% Leu)] or were enriched in leucine [41% leucine (41% L... ... hiện toàn bộ
Tập 291 Số 2 - Trang E381-E387 - 2006
Insulin-sensitive obesity The association between obesity and impaired insulin sensitivity has long been recognized, although a subgroup of obese individuals seems to be protected from insulin resistance. In this study, we systematically studied differences in adipose tissue biology between insulin-sensitive (IS) and insulin-resistant (IR) individuals with morbid obesity. On the basis of glucose infusion rate duri... ... hiện toàn bộ
Tập 299 Số 3 - Trang E506-E515 - 2010