Noninvasive determination of local cerebral metabolic rate of glucose in man

American Journal of Physiology - Endocrinology and Metabolism - Tập 238 Số 1 - Trang E69-E82 - 1980
S C Huang, M E Phelps, Edward J. Hoffman, K. Sideris, Carl Selin, Dietmar Kuhl

Tóm tắt

A method for the determination of local cerebral metabolic rates of glucose (LCMRGlc) in normal man is described. The method employs [18F]2-fluoro-2-deoxy-D-glucose (FDG) and emission-computed tomography (ECT). FDG was injected intravenously as a bolus. Radioactivities in separate brain regions were measured with ECT. Plasma FDG concentration following injection was measured from blood samples. A mathematical model that describes the kinetics of FDG transports was employed to determine the transport rate constants of FDG and to convert the radioactivity measurements to metabolic rates. The model has taken into account the possible dephosphorylation reaction from FDG-6-PO4 (FDG-6-P) to free FDG in brain tissues. Experiments were performed in 13 normal volunteers. The rate constants of FDG in man were found to be comparable to those of deoxyglucose in rat and in rhesus monkey. The average LCMRGlc in gray and in white matter were found to be 7.30 +/- 1.18 (SD) and 3.41 +/- 0.64 mg/min per 100 g brain tissue, respectively. The subject-to-subject variation of LCMRGlc as measured by the present method was comparable to those of other methods that measure whole-brain CMRGlc.

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Tài liệu tham khảo

1978, Med., 19, 1154

10.1111/j.1471-4159.1968.tb10333.x

10.1152/jappl.1967.23.2.183

10.1007/BF01478536

10.1016/0306-4522(78)90106-9

10.1111/j.1471-4159.1973.tb05996.x

10.1097/00004728-197903060-00018

10.1002/ana.410060502

1977, Chem., 42, 2341

10.1002/ana.410040402

KUHL D. E., 1977, H. Ingvar and N. A. Lassen. Copenhagen: Munksgaard, 192

MAKER H. S., 1976, Brown, 279

10.1161/01.CIR.7.5.724

OLDENDORF W. H, 1971, Am. J. Physiol., 221, 1629, 10.1152/ajplegacy.1971.221.6.1629

10.1016/S0001-2998(77)80042-1

PHELPS M. E., 1977, H. Ingvar and N. A. Lassen. Copenhagen: Munksgaard, 446

PHELPS M. E., 1978, J. Nucl. Med., 19, 635

PHELPS M, E, 1977, WedicaZ Radionuclide Imaging. Vienna: Int. At. Energy Assoc., 1, 233

10.1109/TNS.1979.4330528

1978, Science, 199, 986, 10.1126/science.414358

10.1161/01.RES.44.1.127

ROBINSON G. D., 1978, J. NucZ. Med., 19, 701

10.1172/JCI102150

10.1145/321592.321597

10.1111/j.1471-4159.1977.tb10649.x

SOLS A., 1954, J. BioZ. Chem., 210, 581, 10.1016/S0021-9258(18)65384-0

10.1097/00000542-197201000-00013

WHITE A., P., 1964, New York: McGraw, 365

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Thông tin xuất bản

American Journal of Physiology - Endocrinology and Metabolism

Tập 238 Số 1

E69-E82

Thông tin tác giả