Quantitative estimation of insulin sensitivity.

American Journal of Physiology - Endocrinology and Metabolism - Tập 236 Số 6 - Trang E667 - 1979
Richard N. Bergman, Y.Z. Ider, Charles R. Bowden, Claudio Cobelli

Tóm tắt

We have evaluated the feasibility of using a mathematical model of glucose disappearance to estimate insulin sensitivity. Glucose was injected into conscious dogs at 100, 200, or 300 mg/kg. The measured time course of insulin was regarded as the "input," and the falling glucose concentration as the "output" of the physiological system storing and using glucose. Seven mathematical models of glucose uptake were compared to identify the representation most capable of simulating glucose disappearance. One specific nonlinear model was superior in that it 1) predicted the time course of glucose after glucose injection, 2) had four parameters that could be precisely estimated, and 3) described individual experiments with similar parameter values. Insulin sensitivity index (SI), defined as the dependence of fractional glucose disappearance on plasma insulin, was the ratio of two parameters of the chosen model and could be estimated with good reproducibility from the 300 mg/kg injection experiments (SI = 7.00 X 10(-4) +/- 24% (coefficient of variation) min-1/(microU/ml) (n = 8)). Thus, from a single glucose injection it is possible to obtain a quantitative index of insulin sensitivity that may have clinical applicability.

Từ khóa


Tài liệu tham khảo

ACKERMAN E,, L, 1965, Biophys., 27, 21

10.1088/0031-9155/9/2/307

10.1109/TAC.1974.1100705

10.1016/0022-5193(71)90152-4

10.1172/JCI107011

10.1210/jcem-25-10-1375

10.1172/JCI108565

10.1115/1.3426718

BERGMAN R, N, 1974, Am. J. Physiol., 227, 1314, 10.1152/ajplegacy.1974.227.6.1314

BERGMAN R. N., 1971, Recent Prog. Horm. Res., 27, 583

10.1152/jappl.1961.16.5.783

10.1210/endo-83-3-572

HETENYI G, 1974, Federation Proc., 33, 1841

10.1172/JCI108006

10.1016/0025-5564(75)90110-8

MARQUARDT D. W, 1963, Math, 11, 431

10.2337/diab.22.7.507

RADZIUK J., K, 1974, Federation Proc., 33, 1855

10.1007/BF01234496

10.2337/diab.22.2.94

SHANNON J. A, 1939, Rev., 19, 63

SHEN S.-W., 1970, J. Clin. Inuest., 49, 2X

SHERWIN R. S., 1974, J. CZin. Inu~t., 53, 1481

10.1172/JCI108275

10.1172/JCI109054

Thông tin
Thông tin xuất bản

American Journal of Physiology - Endocrinology and Metabolism

Tập 236 Số 6

E667

Thông tin tác giả