American Journal of Physiology - Endocrinology and Metabolism

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Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans
American Journal of Physiology - Endocrinology and Metabolism - Tập 287 Số 1 - Trang E174-E181 - 2004
Claude Gronfier, Kenneth P. Wright, Richard E. Kronauer, Megan E. Jewett, Charles A. Czeisler
It has been shown in animal studies that exposure to brief pulses of bright light can phase shift the circadian pacemaker and that the resetting action of light is most efficient during the first minutes of light exposure. In humans, multiple consecutive days of exposure to brief bright light pulses have been shown to phase shift the circadian pacemaker. The aim of the present study was t...... hiện toàn bộ
O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon
American Journal of Physiology - Endocrinology and Metabolism - Tập 285 Số 3 - Trang E584-E591 - 2003
Gipsy Majumdar, Ashley Harmon, Rosalind P. Candelaria, Antonio Martinez-Hernandez, Rajendra Raghow, Solomon S. Solomon
Both insulin and glucagon stimulate steady-state levels of Sp1 transcription factor, but only insulin stimulates transcription of the calmodulin (CaM) gene in liver. Because O-glycosylation of Sp1 by O-linked N-acetylglucosamine ( O-GlcNAc) is thought to regulate its ability to activate transcription, we assayed the levels of Sp1 with anti-Sp1 and anti- O-GlcNAc antibodies in Western blots...... hiện toàn bộ
High glucose and insulin promoteO-GlcNAc modification of proteins, including α-tubulin
American Journal of Physiology - Endocrinology and Metabolism - Tập 284 Số 2 - Trang E424-E434 - 2003
Jennie Walgren, Timothy S. Vincent, Kevin L. Schey, Maria G. Buse
Increased flux through the hexosamine biosynthesis pathway has been implicated in the development of glucose-induced insulin resistance and may promote the modification of certain proteins with O-linked N-acetylglucosamine ( O-GlcNAc). L6 myotubes (a model of skeletal muscle) were incubated for 18 h in 5 or 25 mM glucose with or without 10 nM insulin. As assessed by immunoblotting with an ...... hiện toàn bộ
Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity
American Journal of Physiology - Endocrinology and Metabolism - Tập 295 Số 1 - Trang E17-E28 - 2008
Ronald J. Copeland, John Bullen, Gerald W. Hart
O-linked β- N-acetylglucosamine ( O-GlcNAc) is a dynamic posttranslational modification that, analogous to phosphorylation, cycles on and off serine and/or threonine hydroxyl groups. Cycling of O-GlcNAc is regulated by the concerted actions of O-GlcNAc transferase and O-GlcNAcase. GlcNAcylation is a nutrient/stress-sensitive modification that regulates proteins involved in a wide array of ...... hiện toàn bộ
Chronically elevated plasma C-type natriuretic peptide level stimulates skeletal growth in transgenic mice
American Journal of Physiology - Endocrinology and Metabolism - Tập 297 Số 6 - Trang E1339-E1348 - 2009
Takei Kake, Hidetomo Kitamura, Yuichiro Adachi, Tetsuro Yoshioka, Tomoyuki Watanabe, Hiroaki Matsushita, Toshihito Fujii, Eri Kondo, Takanori Tachibe, Yosuke Kawase, Kou-ichi Jishage, Akihiro Yasoda, Masashi Mukoyama, Kazuwa Nakao
C-type natriuretic peptide (CNP) plays a critical role in endochondral ossification through guanylyl cyclase-B (GC-B), a natriuretic peptide receptor subtype. Cartilage-specific overexpression of CNP enhances skeletal growth and rescues the dwarfism in a transgenic achondroplasia model with constitutive active mutation of fibroblast growth factor receptor-3. For future clinical applicatio...... hiện toàn bộ
Effects of high altitude and water deprivation on arginine vasopressin release in men
American Journal of Physiology - Endocrinology and Metabolism - Tập 286 Số 1 - Trang E20-E24 - 2004
C M Maresh, William J. Kraemer, Daniel A. Judelson, Jaci L. VanHeest, L. A. Trad, Jonna M. Kulikowich, K. L. Goetz, Allen Cymerman, Allan J. Hamilton
High-altitude exposure changes the distribution of body water and electrolytes. Arginine vasopressin (AVP) may influence these alterations. The purpose of this study was to examine the effect of a 24-h water deprivation trial (WDT) on AVP release after differing altitude exposures. Seven healthy males (age 22 ± 1 yr, height 176 ± 2 cm, mass 75.3 ± 1.8 kg) completed three WDTs: at sea leve...... hiện toàn bộ
Bone as an ion exchange system: evidence for a link between mechanotransduction and metabolic needs
American Journal of Physiology - Endocrinology and Metabolism - Tập 282 Số 4 - Trang E851-E864 - 2002
Alessandro Rubinacci, M. Covini, C. Bisogni, Isabella Villa, Manuela Galli, Carla Palumbo, Marzia Ferretti, Maria Antonietta Muglia, Gastone Marotti
To detect whether the mutual interaction occurring between the osteocytes-bone lining cells system (OBLCS) and the bone extracellular fluid (BECF) is affected by load through a modification of the BECF-extracellular fluid (ECF; systemic extracellular fluid) gradient, mice metatarsal bones immersed in ECF were subjected ex vivo to a 2-min cyclic axial load of different amplitudes and frequ...... hiện toàn bộ
cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration
American Journal of Physiology - Endocrinology and Metabolism - Tập 303 Số 1 - Trang E1-E17 - 2012
Rebecca Berdeaux, Randi Stewart
Among organ systems, skeletal muscle is perhaps the most structurally specialized. The remarkable subcellular architecture of this tissue allows it to empower movement with instructions from motor neurons. Despite this high degree of specialization, skeletal muscle also has intrinsic signaling mechanisms that allow adaptation to long-term changes in demand and regeneration after acute dama...... hiện toàn bộ
Biochemical and physiological function of stearoyl-CoA desaturase
American Journal of Physiology - Endocrinology and Metabolism - Tập 297 Số 1 - Trang E28-E37 - 2009
Chad M. Paton, James M. Ntambi
A key and highly regulated enzyme that is required for the biosynthesis of monounsaturated fatty acids is stearoyl-CoA desaturase (SCD), which catalyzes the D9- cis desaturation of a range of fatty acyl-CoA substrates. The preferred substrates are palmitoyl- and stearoyl-CoA, which are converted into palmitoleoyl- and oleoyl-CoA respectively. Oleate is the most abundan...... hiện toàn bộ
Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing
American Journal of Physiology - Endocrinology and Metabolism - Tập 299 Số 6 - Trang E1066-E1075 - 2010
Chad M. Paton, James M. Ntambi
Stearoyl-CoA desaturase-1 (SCD-1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids (MUFA), which are required for efficient neutral lipid esterification. In the present investigation, we demonstrate that loss of SCD-1 activity increases free cholesterol (FC) content and induces Xbp-1 splicing. We assessed the small molecule SCD-1 inhibitor A939572 on [... hiện toàn bộ
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