Effects of high altitude and water deprivation on arginine vasopressin release in men

American Journal of Physiology - Endocrinology and Metabolism - Tập 286 Số 1 - Trang E20-E24 - 2004
C M Maresh1, William J. Kraemer, Daniel A. Judelson, Jaci L. VanHeest, L. A. Trad, Jonna M. Kulikowich, K. L. Goetz, Allen Cymerman, Allan J. Hamilton
1Department of Kinesiology, Human Performance Laboratory, University of Connecticut, 2095 Hillside Road, U-1110, Storrs, CT 06269-1110, USA. [email protected]

Tóm tắt

High-altitude exposure changes the distribution of body water and electrolytes. Arginine vasopressin (AVP) may influence these alterations. The purpose of this study was to examine the effect of a 24-h water deprivation trial (WDT) on AVP release after differing altitude exposures. Seven healthy males (age 22 ± 1 yr, height 176 ± 2 cm, mass 75.3 ± 1.8 kg) completed three WDTs: at sea level (SL), after acute altitude exposure (2 days) to 4,300 m (AA), and after prolonged altitude exposure (20 days) to 4,300 m (PA). Body mass, standing and supine blood pressures, plasma osmolality (Posm), and plasma AVP (PAVP) were measured at 0, 12, 16, and 24 h of each WDT. Urine volume was measured at each void throughout testing. Baseline Posm increased from SL to altitude (SL 291.7 ± 0.8 mosmol/kgH2O, AA 299.6 ± 2.2 mosmol/kgH2O, PA 302.3 ± 1.5 mosmol/kgH2O, P < 0.05); however, baseline PAVP measurements were similar. Despite similar Posm values, the maximal PAVP response during the WDT (at 16 h) was greater at altitude than at SL (SL 1.7 ± 0.5 pg/ml, AA 6.4 ± 0.7 pg/ml, PA 8.7 ± 0.9 pg/ml, P < 0.05). In conclusion, hypoxia appeared to alter AVP regulation by raising the osmotic threshold and increasing AVP responsiveness above that threshold.

Từ khóa


Tài liệu tham khảo

Armstrong LE. Performing in Extreme Environments. Champaign, IL: Human Kinetics, 2000.

10.1210/jcem-25-11-1481

10.1152/japplphysiol.00936.2001

10.1001/jama.1984.03350040054023

10.1093/ajh/5.9.600

10.1056/NEJM198704233161707

10.1152/jappl.1975.38.4.636

Fulco CF. Human acclimatization and physical performance at high altitude. J Appl Sports Sci Res 2: 79-84, 1988.

10.1677/joe.0.1250061

10.1055/s-0028-1095855

10.1227/00006123-198611000-00024

Hannon JP and Chinn KS. Effects of high altitude on body fluid volumes. Fed Proc 26: 719, 1967.

Kamoi K, White K, and Robertson GL. Opiates elevate the osmotic threshold for vasopressin (VP) release in rats (Abstract). Clin Res 27: 254A, 1979.

10.1136/thx.52.1.84

10.1152/ajpregu.1994.267.5.R1342

10.1111/j.1475-097X.1984.tb00128.x

Ramirez G, Bittle PA, Agosti SJ, Dietz J, and Colice GL. Salt loading test in a population adapted to moderately high altitude living (3,000 m). Aviat Space Environ Med 64: 831-838, 1993.

Ramirez G, Hammond M, Agosti SJ, Bittle PA, Dietz JR, and Colice GL. Effects of hypoxemia at sea level and high altitude on sodium excretion and hormonal levels. Aviat Space Environ Med 63: 891-898, 1992.

Ramirez G, Pineda D, Bittle PA, Rabb H, Rosen R, Vesely D, and Sasaki S. Partial renal resistance to arginine vasopressin as an adaptation to high altitude living. Aviat Space Environ Med 69: 58-65, 1998.

Ramirez G, Pineda DO, Bittle PA, Agosti SJ, Rabb HA, and Dietz JR. Salt excretory capacity in natives adapted to moderate high altitude living after acute mobilization to sea level. Aviat Space Environ Med 66: 1063-1070, 1995.

Reeves JT, Mazzeo RS, Wolfel EE, and Young AJ. Increased arterial pressure after acclimatization to 4300 m: possible role of norepinephrine. Int J Sports Med 13 Suppl 1: S1-S8, 1992.

10.1007/s00424-002-0894-x

10.1016/0002-9343(82)90825-7

10.1046/j.1365-201X.1998.00335.x

Shields JL, Hannon JP, Carson RP, Chinn KS, and Evans WO. Pathophysiology of acute mountain sickness. In: Biomedicine of High Terrestrial Elevations, edited by Henauer AH. Washington, DC: US Army Medical Research Development Command, 1969, p. 9-23.

10.1056/NEJM196901232800402

10.1152/ajpheart.1983.245.3.H399

10.1152/jappl.1994.76.4.1643

10.1016/0006-8993(77)90607-2

Young AJ and Young PM. Human acclimatization to high terrestrial altitudes. In: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, edited by Pandolf KB, Sawka MN, and Gonzalez RR. Indianapolis, IN: Benchmark, 1988, p. 497-543.

Zerbe RL, Miller JZ, and Robertson GL. The reproducibility and heritability of individual differences in osmoregulatory function in normal human subjects. J Lab Clin Med 117: 51-59, 1991.

Thông tin
Thông tin xuất bản

American Journal of Physiology - Endocrinology and Metabolism

Tập 286 Số 1

E20-E24

Thông tin tác giả