American Association for the Advancement of Science (AAAS)

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Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster
American Association for the Advancement of Science (AAAS) - Tập 263 Số 5150 - Trang 1128-1130 - 1994
William C. Orr, Rajindar S. Sohal
The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time,...... hiện toàn bộ
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
American Association for the Advancement of Science (AAAS) - Tập 289 Số 5484 - Trang 1567-1569 - 2000
Simon Melov, Joanne Ravenscroft, Sarwatt Malik, Matthew S. Gill, David W. Walker, Peter Clayton, Douglas C. Wallace, Bernard Malfroy, Susan R. Doctrow, Gordon J. Lithgow
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulte...... hiện toàn bộ
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
American Association for the Advancement of Science (AAAS) - Tập 349 Số 6248 - 2015
Michel Goedert
Converging paradigms in neurodegeneration Parkinson's disease and Alzheimer's disease are progressive neurodegenerative diseases with increasing prevalence in our aging populations. Recent evidence suggests that some of the molecular mechanisms involved in the pathology of these diseases have similarities to those observed in infectious prion diseases suc...... hiện toàn bộ
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
American Association for the Advancement of Science (AAAS) - Tập 273 Số 5273 - Trang 361-364 - 1996
Jingdong Liu, Bertold Schrank, R Waterston
The degenerin family of proteins in Caenorhabditis elegans is homologous to subunits of the mammalian amiloride-sensitive epithelial sodium channels. Mutations in nematode degenerins cause cell death, probably because of defects in channel function. Genetic evidence was obtained that the unc-105... hiện toàn bộ
A Drosophila Mechanosensory Transduction Channel
American Association for the Advancement of Science (AAAS) - Tập 287 Số 5461 - Trang 2229-2234 - 2000
Richard G. Walker, Aarron Willingham, Charles S. Zuker
Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, little is known about the molecular ...... hiện toàn bộ
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
American Association for the Advancement of Science (AAAS) - Tập 326 Số 5953 - Trang 688-694 - 2009
T.M. Schmeing, Rebecca M. Voorhees, A.C. Kelley, Yong‐Gui Gao, F.V. Murphy, John R. Weir, V. Ramakrishnan
Ribosomes Caught in Translation To synthesize proteins, the ribosome must select cognate transfer RNAs (tRNAs) based on base-pairing with the messenger RNA (mRNA) template (a process known as decoding), form a peptide bond, and then move the mRNA:tRNA assembly relative to the ribosome (a process known as translocation). Decoding and transloca...... hiện toàn bộ
A Unified Theory Based on SO (5) Symmetry of Superconductivity and Antiferromagnetism
American Association for the Advancement of Science (AAAS) - Tập 275 Số 5303 - Trang 1089-1096 - 1997
Shengbai Zhang
The complex phase diagram of high-critical temperature ( T c ) superconductors can be deduced from an SO (5) symmetry principle that unifies antiferromagnetism and d -wave superconductivity. Th...... hiện toàn bộ
Behavioral Sensitivity to Purinergic Drugs Parallels Ethanol Sensitivity in Selectively Bred Mice
American Association for the Advancement of Science (AAAS) - Tập 224 Số 4648 - Trang 519-521 - 1984
William R. Proctor, Thomas V. Dunwiddie
Behavioral responses to an adenosine receptor agonist and antagonist were examined in mice genetically selected for differential sensitivity to the soporific effects of ethanol. Both ethanol and the adenosine receptor agonist L-phenylisopropyladenosine had greater sedative and hypothermic effects in ethanol-sensitive "long-sleep" mice than in ethanol-insensitive "short-sleep" mice. Long-sl...... hiện toàn bộ
Stability, Precision, and Near-24-Hour Period of the Human Circadian Pacemaker
American Association for the Advancement of Science (AAAS) - Tập 284 Số 5423 - Trang 2177-2181 - 1999
Charles A. Czeisler, Jeanne F. Duffy, Theresa L. Shanahan, Emery N. Brown, Jude F. Mitchell, David W. Rimmer, Joseph M. Ronda, Edward J. Silva, James S. Allan, Jonathan S. Emens, Derk‐Jan Dijk, Richard E. Kronauer
Regulation of circadian period in humans was thought to differ from that of other species, with the period of the activity rhythm reported to range from 13 to 65 hours (median 25.2 hours) and the period of the body temperature rhythm reported to average 25 hours in adulthood, and to shorten with age. However, those observations were based on studies of humans exposed to light levels suffic...... hiện toàn bộ
Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
American Association for the Advancement of Science (AAAS) - Tập 324 Số 5928 - Trang 797-801 - 2009
Junying Yu, Kejin Hu, Kim Smuga-Otto, Shulan Tian, Ron Stewart, Igor I. Slukvin, James A. Thomson
Designer Stem Cells Despite their promise for use as disease models and in regenerative medicine, the generation of human-induced pluripotent stem (iPS) cells has been hindered by the integration of vector and transgenes in the host cell genome. Recent studies using the Cre/LoxP recombination strategy and the piggyBac transposon approach have...... hiện toàn bộ
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