American Association for the Advancement of Science (AAAS)
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Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogasterThe hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time,... ...
American Association for the Advancement of Science (AAAS) - Tập 263 Số 5150 - Trang 1128-1130 - 1994
PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene SuperfamilyAn antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracell... ...
American Association for the Advancement of Science (AAAS) - Tập 247 Số 4947 - Trang 1219-1222 - 1990
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of
Caenorhabditis elegans
with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulte... ...
American Association for the Advancement of Science (AAAS) - Tập 289 Số 5484 - Trang 1567-1569 - 2000
Excitation Spectra of Circular, Few-Electron Quantum DotsStudies of the ground and excited states in semiconductor quantum dots containing 1 to 12 electrons showed that the quantum numbers of the states in the excitation spectra can be identified and compared with exact calculations. A magnetic field induces transitions between the ground and excited states. These transitions were analyzed in terms of crossings between single-particle states, si... ...
American Association for the Advancement of Science (AAAS) - Tập 278 Số 5344 - Trang 1788-1792 - 1997
Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β InactivationGlycogen synthase kinase 3β (GSK3β) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3β activity is the primary mechanism that regulates this widely expressed active kinase. Although the protein kinase Akt inhibits GSK3β by phosphorylation at the N terminus, preventing Akt-mediated phosphorylation does not affect the cell-survival pathway activated through the GSK... ...
American Association for the Advancement of Science (AAAS) - Tập 320 Số 5876 - Trang 667-670 - 2008
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synucleinConverging paradigms in neurodegeneration
Parkinson's disease and Alzheimer's disease are progressive neurodegenerative diseases with increasing prevalence in our aging populations. Recent evidence suggests that some of the molecular mechanisms involved in the pathology of these diseases have similarities to those observed in infectious prion diseases suc... ...
American Association for the Advancement of Science (AAAS) - Tập 349 Số 6248 - 2015
Genetic Evidence for High-Altitude Adaptation in TibetNo Genetic Vertigo
Peoples living in high altitudes have adapted to their situation (see the Perspective by
Storz
). To identify gene regions that might have contributed to high-altitude adaptation in Tibetans,
Simonson
et al.
(p.
hiện toàn bộ
American Association for the Advancement of Science (AAAS) - Tập 329 Số 5987 - Trang 72-75 - 2010
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
The degenerin family of proteins in
Caenorhabditis elegans
is homologous to subunits of the mammalian amiloride-sensitive epithelial sodium channels. Mutations in nematode degenerins cause cell death, probably because of defects in channel function. Genetic evidence was obtained that the
unc-105...
American Association for the Advancement of Science (AAAS) - Tập 273 Số 5273 - Trang 361-364 - 1996
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43°C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are... ...
American Association for the Advancement of Science (AAAS) - Tập 288 Số 5464 - Trang 306-313 - 2000
14 C Activity and Global Carbon Cycle Changes over the Past 50,000 Years
A series of
14
C measurements in Ocean Drilling Program cores from the tropical Cariaco Basin, which have been correlated to the annual-layer counted chronology for the Greenland Ice Sheet Project 2 (GISP2) ice core, provides a high-resolution calibration of the radiocarbon time scale back to 50,000 years before the present. Indepen... ...
American Association for the Advancement of Science (AAAS) - Tập 303 Số 5655 - Trang 202-207 - 2004
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