American Association for the Advancement of Science (AAAS)

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Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster
American Association for the Advancement of Science (AAAS) - Tập 263 Số 5150 - Trang 1128-1130 - 1994
William C. Orr, Rajindar S. Sohal
The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower... hiện toàn bộ
PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily
American Association for the Advancement of Science (AAAS) - Tập 247 Số 4947 - Trang 1219-1222 - 1990
Peter J. Newman, Michael C. Berndt, Jack Gorski, Gilbert White, Suzanne Lyman, Cathy Paddock, William A. Müller
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular imm... hiện toàn bộ
Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics
American Association for the Advancement of Science (AAAS) - Tập 289 Số 5484 - Trang 1567-1569 - 2000
Simon Melov, Joanne Ravenscroft, Sarwatt Malik, Matthew S. Gill, David W. Walker, Peter Clayton, Douglas C. Wallace, Bernard Malfroy, Susan R. Doctrow, Gordon J. Lithgow
We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appear... hiện toàn bộ
Excitation Spectra of Circular, Few-Electron Quantum Dots
American Association for the Advancement of Science (AAAS) - Tập 278 Số 5344 - Trang 1788-1792 - 1997
Leo P. Kouwenhoven, Tjerk H. Oosterkamp, M. W. S. Danoesastro, Mikio Eto, D. G. Austing, Takashi Honda, Seigo Tarucha
Studies of the ground and excited states in semiconductor quantum dots containing 1 to 12 electrons showed that the quantum numbers of the states in the excitation spectra can be identified and compared with exact calculations. A magnetic field induces transitions between the ground and excited states. These transitions were analyzed in terms of crossings between single-particle states, singlet-tr... hiện toàn bộ
Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation
American Association for the Advancement of Science (AAAS) - Tập 320 Số 5876 - Trang 667-670 - 2008
Tina M. Thornton, Gustavo Pedraza‐Alva, Bin Deng, C. David Wood, Alexander Aronshtam, James L. Clements, Guadalupe Sabio, Roger J. Davis, Dwight E. Matthews, Bradley W. Doble, Mercedes Rincón
Glycogen synthase kinase 3β (GSK3β) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3β activity is the primary mechanism that regulates this widely expressed active kinase. Although the protein kinase Akt inhibits GSK3β by phosphorylation at the N terminus, preventing Akt-mediated phosphorylation does not affect the cell-survival pathway activated through the GSK3β subst... hiện toàn bộ
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
American Association for the Advancement of Science (AAAS) - Tập 349 Số 6248 - 2015
Michel Goedert
Converging paradigms in neurodegeneration Parkinson's disease and Alzheimer's disease are progressive neurodegenerative diseases with increasing prevalence in our aging populations. Recent evidence suggests that some of the molecular mechanisms involved in the pathology of these diseases have similarities to those observed in infectious prion diseases such as bovine spongiform encephalopathy (mad ... hiện toàn bộ
Genetic Evidence for High-Altitude Adaptation in Tibet
American Association for the Advancement of Science (AAAS) - Tập 329 Số 5987 - Trang 72-75 - 2010
Tatum S. Simonson, Yingzhong Yang, Chad Huff, Haixia Yun, Qin Ga, David J. Witherspoon, Zhenzhong Bai, Felipe R. Lorenzo, Jinchuan Xing, Lynn B. Jorde, Josef T. Prchal, Ri-Li Ge
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might have contributed to high-altitude adaptation in Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Tibetans, Han Chinese, and Japanese, while Yi et al. (p. 75 ) performed compar... hiện toàn bộ
Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen
American Association for the Advancement of Science (AAAS) - Tập 273 Số 5273 - Trang 361-364 - 1996
Jingdong Liu, Bertold Schrank, R Waterston
The degenerin family of proteins in Caenorhabditis elegans is homologous to subunits of the mammalian amiloride-sensitive epithelial sodium channels. Mutations in nematode degenerins cause cell death, probably because of defects in channel function. Genetic evidence was obtained that the unc-105 gene product represents a degenerin homolog affecting C. elegans muscles and that this putative channel... hiện toàn bộ
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
American Association for the Advancement of Science (AAAS) - Tập 288 Số 5464 - Trang 306-313 - 2000
Michael J. Caterina, Andreas Leffler, Annika B. Malmberg, William J. Martin, Jodie A. Trafton, Karla R. Petersen-Zeitz, Martin Koltzenburg, Allan I. Basbaum, David Julius
The capsaicin (vanilloid) receptor VR1 is a cation channel expressed by primary sensory neurons of the “pain” pathway. Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43°C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known. Here, we demonstrate that sensory neurons from mice lacking VR1 are severely deficient in t... hiện toàn bộ
14 C Activity and Global Carbon Cycle Changes over the Past 50,000 Years
American Association for the Advancement of Science (AAAS) - Tập 303 Số 5655 - Trang 202-207 - 2004
Konrad A Hughen, Scott J. Lehman, John Southon, Jonathan T. Overpeck, Olivier Marchal, C. Herring, J. C. Turnbull
A series of 14 C measurements in Ocean Drilling Program cores from the tropical Cariaco Basin, which have been correlated to the annual-layer counted chronology for the Greenland Ice Sheet Project 2 (GISP2) ice core, provides a high-resolution calibration of the radiocarbon time scale back to 50,000 years before the present. Independent radiometric dating of events correlated to GISP2 suggests tha... hiện toàn bộ
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