Extension of Life-Span by Overexpression of Superoxide Dismutase and Catalase in Drosophila melanogaster

American Association for the Advancement of Science (AAAS) - Tập 263 Số 5150 - Trang 1128-1130 - 1994
William C. Orr1, Rajindar S. Sohal1
1Department of Biological Sciences, Southern Methodist University, Dallas, TX, 75275

Tóm tắt

The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.

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American Association for the Advancement of Science (AAAS)

Tập 263 Số 5150

1128-1130

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