Behavioral Sensitivity to Purinergic Drugs Parallels Ethanol Sensitivity in Selectively Bred Mice

American Association for the Advancement of Science (AAAS) - Tập 224 Số 4648 - Trang 519-521 - 1984
William R. Proctor1, Thomas V. Dunwiddie1,2
1Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262.
2Veterans Administration Medical Research Service, Denver 80220

Tóm tắt

Behavioral responses to an adenosine receptor agonist and antagonist were examined in mice genetically selected for differential sensitivity to the soporific effects of ethanol. Both ethanol and the adenosine receptor agonist L-phenylisopropyladenosine had greater sedative and hypothermic effects in ethanol-sensitive "long-sleep" mice than in ethanol-insensitive "short-sleep" mice. Long-sleep mice were also more sensitive to the excitatory behavioral effects of theophylline, an adenosine receptor antagonist. These data suggest that adenosine may be an endogenous mediator of responses to ethanol.

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