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We thank the Lithgow lab and A. Seyed Jazayeri-Dezfuly for critical and helpful discussions. M.S.G. is a Medical Research Council (MRC)–supported Training Fellow. D.W.W. is also supported by the MRC and S. Malik was supported by Research into Aging. D.C.W. and S. Melov were supported in part by NIH grants AG-13154 and NS21328 awarded to D.C.W. All strains were obtained from the Caenorhabditis Genetics Center.