Interaction Between a Putative Mechanosensory Membrane Channel and a Collagen

American Association for the Advancement of Science (AAAS) - Tập 273 Số 5273 - Trang 361-364 - 1996
Jingdong Liu1, Bertold Schrank1, R Waterston1
1Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA

Tóm tắt

The degenerin family of proteins in Caenorhabditis elegans is homologous to subunits of the mammalian amiloride-sensitive epithelial sodium channels. Mutations in nematode degenerins cause cell death, probably because of defects in channel function. Genetic evidence was obtained that the unc-105 gene product represents a degenerin homolog affecting C. elegans muscles and that this putative channel interacts with type IV collagen in the extracellular matrix underlying the muscle cell. This interaction may serve as a mechanism of stretch-activated muscle contraction, and this system could provide a molecular model for the activation of mechanosensitive ion channels.

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