miRNAs as biomarkers in prostate cancer

Clinical and Translational Oncology - Tập 14 - Trang 803-811 - 2012
Irene Casanova-Salas1, José Rubio-Briones2, Antonio Fernández-Serra1, Jose Antonio López-Guerrero1
1Laboratory of Molecular Biology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
2Department of Urology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain

Tóm tắt

Current prostate cancer (PCa) diagnosis is based in the serum prostate-specific antigen biomarker and digital rectal examination. However, these methods are limited by a low predictive value (24–37 %) and a high risk of mistaken results. During last years, new promising biomarkers such as Prostate Cancer Antigen 3 (PCA-3) and TMPRSS2-ETS fusion genes have been evaluated for their clinical use. However, the search of new biomarkers that could be used for PCa diagnosis and prognosis is still needed. Recent studies have demonstrated that the aberrant expression of microRNAs (miRNAs), small non-coding RNAs that negatively regulate gene expression, is related with the development of several cancers, including PCa. Since miRNAs serve as phenotypic signatures of different cancers, they appear as potential diagnostic, prognostic and therapeutic tools. Here, we review the current knowledge of miRNA expression patterns in PCa and their role in PCa prognosis and therapeutics.

Tài liệu tham khảo

Tricoli JV, Schoenfeldt M, Conley BA (2004) Detection of prostate cancer and predicting progression: current and future diagnostic markers. Clin Cancer Res 10:3943–3953

Salagierski M, Schalken JA (2012) Molecular diagnosis of prostate cancer: PCA3 and TMPRSS2:ERG gene fusion. J Urol 187:795–801

Ryan BM, Robles AI, Harris CC (2010) Genetic variation in microRNA. Nat Rev Cancer 10:389–402

Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M et al (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. PNAS 102:13944–13949

Epis MR, Giles KM, Barker A, Kendrick TS, Leedman PJ (2009) miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer. J Biol Chem 284:24696–24704

Si M-L, Zhu S, Wu H, Lu Z, Wu F et al (2007) miR-21-mediated tumor growth. Oncogene 26:2799–2803

Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS et al (2010) Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal 3:ra29

Mihelich BL, Khramtsova EA, Arva N, Vaishnav A, Johnson DN et al (2011) miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J Biol Chem 286:44503–44511

Eades G, Yao Y, Yang M, Zhang Y, Chumsri S et al (2011) MiR-200a regulates SIRT1 and EMT-like transformation in mammary epithelial cells. J Biol Chem 286:25992–26002

Chan YC, Banerjee J, Choi SY, Sen CK (2012) miR-210: the master hypoxamir. Microcirculation 19:215–223

Wei J-J, Wu X, Peng Y, Shi G, Basturk O et al (2011) Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. Clin Cancer Res 17:1297–1305