RAS Is Regulated by the let-7 MicroRNA Family

Abrahante, 2003, The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs, Dev. Cell, 4, 625, 10.1016/S1534-5807(03)00127-8

Ahrendt, 2001, Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung, Cancer, 92, 1525, 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO;2-H

Ambros, 1999, Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells, Development, 126, 1947, 10.1242/dev.126.9.1947

Bartel, 2004, MicroRNAs: Genomics, biogenesis, mechanism, and function, Cell, 116, 281, 10.1016/S0092-8674(04)00045-5

Beitel, 1990, Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction, Nature, 348, 503, 10.1038/348503a0

Berset, 2001, Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development, Science, 291, 1055, 10.1126/science.1055642

Brennecke, 2003, bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila, Cell, 113, 25, 10.1016/S0092-8674(03)00231-9

Calin, 2002, Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia, Proc. Natl. Acad. Sci. USA, 99, 15524, 10.1073/pnas.242606799

Calin, 2004, Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers, Proc. Natl. Acad. Sci. USA, 101, 2999, 10.1073/pnas.0307323101

Ceol, 2004, A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling, Dev. Cell, 6, 563, 10.1016/S1534-5807(04)00065-6

Chang, 2004, MicroRNAs act sequentially and asymmetrically to control chemosensory laterality in the nematode, Nature, 430, 785, 10.1038/nature02752

Chen, 2004, MicroRNAs modulate hematopoietic lineage differentiation, Science, 303, 83, 10.1126/science.1091903

Dent, 1998, Post-embryonic expression pattern of C. elegans let-60 ras reporter constructs, Mech. Dev., 72, 179, 10.1016/S0925-4773(98)00026-4

Eisenmann, 1997, Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation, Genetics, 146, 553, 10.1093/genetics/146.2.553

Gauwerky, 1989, Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia, Proc. Natl. Acad. Sci. USA, 86, 8867, 10.1073/pnas.86.22.8867

Grosshans, 2005, The temporal patterning microRNA let-7 controls several transcription factors during the larval to adult transition in C. elegans, Dev. Cell, 8, 321, 10.1016/j.devcel.2004.12.019

Han, 1990, The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans, Genetics, 126, 899, 10.1093/genetics/126.4.899

Han, 1990, let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein, Cell, 63, 921, 10.1016/0092-8674(90)90495-Z

Hopper, 2000, ARK-1 inhibits EGFR signaling in C. elegans, Mol. Cell, 6, 65, 10.1016/S1097-2765(00)00008-3

Hutvágner, G., Simard, M.J., Mello, C.C., and Zamore, P.D. (2004). Sequence-specific inhibition of small RNA function. PLoS Biol. 2(4): e98. DOI: 10.1371/journal.pbio.0020098.

Johnson, 2001, Somatic activation of the K-ras oncogene causes early onset lung cancer in mice, Nature, 410, 1111, 10.1038/35074129

Johnson, 2003, The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter, Dev. Biol., 259, 364, 10.1016/S0012-1606(03)00202-1

Johnston, 2003, A microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans, Nature, 426, 845, 10.1038/nature02255

Katz, 1995, Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates, Cell, 82, 297, 10.1016/0092-8674(95)90317-8

Lagos-Quintana, 2001, Identification of novel genes coding for small expressed RNAs, Science, 294, 853, 10.1126/science.1064921

Lagos-Quintana, 2002, Identification of tissue-specific microRNAs from mouse, Curr. Biol., 12, 735, 10.1016/S0960-9822(02)00809-6

Lau, 2001, An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans, Science, 294, 858, 10.1126/science.1065062

Lee, 2001, An extensive class of small RNAs in Caenorhabditis elegans, Science, 294, 862, 10.1126/science.1065329

Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 843, 10.1016/0092-8674(93)90529-Y

Lee, 1994, unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein, Genes Dev., 8, 60, 10.1101/gad.8.1.60

Lewis, 2003, Prediction of mammalian microRNA targets, Cell, 115, 787, 10.1016/S0092-8674(03)01018-3

Lim, 2003, The microRNAs of Caenorhabditis elegans, Genes Dev., 17, 991, 10.1101/gad.1074403

Lin, 2003, The C. elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target, Dev. Cell, 4, 639, 10.1016/S1534-5807(03)00124-2

Malumbres, 2003, RAS oncogenes: the first 30 years, Nat. Rev. Cancer, 3, 459, 10.1038/nrc1097

McKay, 1986, Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression, EMBO J., 5, 2617, 10.1002/j.1460-2075.1986.tb04542.x

McManus, 2003, MicroRNAs and cancer, Semin. Cancer Biol., 13, 253, 10.1016/S1044-579X(03)00038-5

Meister, 2004, Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing, RNA, 10, 544, 10.1261/rna.5235104

Michael, 2003, Reduced accumulation of specific microRNAs in colorectal neoplasia, Mol. Cancer Res., 1, 882

Moss, 1997, The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA, Cell, 88, 637, 10.1016/S0092-8674(00)81906-6

Pasquinelli, 2000, Conservation across animal phylogeny of the sequence and temporal regulation of the 21 nucleotide C. elegans let-7 heterochronic regulatory RNA, Nature, 408, 86, 10.1038/35040556

Pulciani, 1985, ras gene amplification and malignant transformation, Mol. Cell. Biol., 5, 2836, 10.1128/MCB.5.10.2836

Reinhart, 2000, The 21 nucleotide let-7 RNA regulates C. elegans developmental timing, Nature, 403, 901, 10.1038/35002607

Slack, 2000, The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the lin-29 transcription factor, Mol. Cell, 5, 659, 10.1016/S1097-2765(00)80245-2

Stein, L.D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M.R., Chen, N., Chinwalla, A., Clarke, L., Clee, C., Coghlan, A., et al. (2003). The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol. 1(2) e45 DOI: 10.1371/journal.pbio.0000045.

Sternberg, 1988, Lateral inhibition during vulval induction in Caenorhabditis elegans, Nature, 335, 551, 10.1038/335551a0

Sulston, 1977, Post-embryonic cell lineages of the nematode, Caenorhabditis elegans, Dev. Biol., 56, 110, 10.1016/0012-1606(77)90158-0

Takamizawa, 2004, Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival, Cancer Res., 64, 3753, 10.1158/0008-5472.CAN-04-0637

Tam, 2001, Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA, Gene, 274, 157, 10.1016/S0378-1119(01)00612-6

Tam, 2002, Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesis, J. Virol., 76, 4275, 10.1128/JVI.76.9.4275-4286.2002

Tan, 1998, MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction, Cell, 93, 569, 10.1016/S0092-8674(00)81186-1

Timmons, 2001, Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans, Gene, 263, 103, 10.1016/S0378-1119(00)00579-5

Vella, 2004, The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR, Genes Dev., 18, 132, 10.1101/gad.1165404

Wang, 2001, Pattern formation during C. elegans vulval induction, Curr. Top. Dev. Biol., 51, 189, 10.1016/S0070-2153(01)51006-6

Wightman, 1993, Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans, Cell, 75, 855, 10.1016/0092-8674(93)90530-4

Yoo, 2004, Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development, Science, 303, 663, 10.1126/science.1091639

Yoon, 1995, Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl, Science, 269, 1102, 10.1126/science.7652556