miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1

Thiery, 2003, Epithelial–mesenchymal transitions in development and pathologies, Curr. Opin. Cell Biol., 15, 740, 10.1016/j.ceb.2003.10.006 Kalluri, 2003, Epithelial–mesenchymal transition and its implications for fibrosis, J. Clin. Invest., 112, 1776, 10.1172/JCI200320530 Cano, 2000, The transcription factor snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression, Nat. Cell Biol., 2, 76, 10.1038/35000025 Peinado, 2007, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nat. Rev. Cancer, 7, 415, 10.1038/nrc2131 Batlle, 2000, The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells, Nat. Cell Biol., 2, 84, 10.1038/35000034 Dave, 2011, Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition, J. Biol. Chem., 286, 12024, 10.1074/jbc.M110.168625 Barbera, 2004, Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells, Oncogene, 23, 7345, 10.1038/sj.onc.1207990 Peinado, 2003, Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial–mesenchymal transitions, J. Biol. Chem., 278, 21113, 10.1074/jbc.M211304200 Chen, 2005, MicroRNAs as oncogenes and tumor suppressors, N. Engl. J. Med., 353, 1768, 10.1056/NEJMp058190 Croce, 2005, miRNAs, cancer, and stem cell division, Cell, 122, 6, 10.1016/j.cell.2005.06.036 Korpal, 2008, The miR-200 family inhibits epithelial–mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2, J. Biol. Chem., 283, 14910, 10.1074/jbc.C800074200 Park, 2008, The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2, Genes Dev., 22, 894, 10.1101/gad.1640608 Willis, 2006, Epithelial origin of myofibroblasts during fibrosis in the lung, Proc. Am. Thorac. Soc., 3, 377, 10.1513/pats.200601-004TK Kaimori, 2007, Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro, J. Biol. Chem., 282, 22089, 10.1074/jbc.M700998200 Zeisberg, 2007, Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition, J. Biol. Chem., 282, 23337, 10.1074/jbc.M700194200 Caja, 2007, Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis, Cell. Signal., 19, 683, 10.1016/j.cellsig.2006.09.002 Valcourt, 2005, TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial–mesenchymal cell transition, Mol. Biol. Cell, 16, 1987, 10.1091/mbc.e04-08-0658 Pan, 2009, Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes, Hepatology, 50, 1577, 10.1002/hep.23156 Franco, 2010, Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes, J. Cell Sci., 123, 3467, 10.1242/jcs.068692 Yang, 2006, Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3, Cancer Res., 66, 8617, 10.1158/0008-5472.CAN-06-1308 Rodriguez, 2004, Identification of mammalian microRNA host genes and transcription units, Genome Res., 14, 1902, 10.1101/gr.2722704 Braun, 2010, Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas, Oncogene, 29, 4237, 10.1038/onc.2010.169 Volinia, 2006, A microRNA expression signature of human solid tumors defines cancer gene targets, Proc. Natl. Acad. Sci. USA, 103, 2257, 10.1073/pnas.0510565103 Patnaik, 2010, Overexpression of microRNA miR-30a or miR-191 in A549 lung cancer or BEAS-2B normal lung cell lines does not alter phenotype, PLoS One, 5, e9219, 10.1371/journal.pone.0009219 Wheeler, 2007, In situ detection of animal and plant microRNAs, DNA Cell Biol., 26, 251, 10.1089/dna.2006.0538 Dooley, 2008, Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage, Gastroenterology, 135, 642, 10.1053/j.gastro.2008.04.038 Jayachandran, 2009, SNAI transcription factors mediate epithelial–mesenchymal transition in lung fibrosis, Thorax, 64, 1053, 10.1136/thx.2009.121798 Rowe, 2011, Hepatocyte-derived Snail1 propagates liver fibrosis progression, Mol. Cell. Biol., 31, 2392, 10.1128/MCB.01218-10 Roderburg, 2011, Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis, Hepatology, 53, 209, 10.1002/hep.23922 Yu, 2010, Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells, Oncogene, 29, 4194, 10.1038/onc.2010.167 Come, 2006, Snail and slug play distinct roles during breast carcinoma progression, Clin. Cancer Res., 12, 5395, 10.1158/1078-0432.CCR-06-0478 Elloul, 2005, Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma, Cancer, 103, 1631, 10.1002/cncr.20946 Sugimachi, 2003, Transcriptional repressor snail and progression of human hepatocellular carcinoma, Clin. Cancer Res., 9, 2657