Nanotherapy for Alzheimer's disease and vascular dementia: Targeting senile endothelium

Cooper, 2016, Aortic stiffness, cerebrovascular dysfunction, and memory, Pulse, 4, 69, 10.1159/000448176

Dichgans, 2017, Vascular cognitive impairment, Circ Res, 120, 573, 10.1161/CIRCRESAHA.116.308426

Greenberg, 2017, Vascular disease and neurodegeneration: advancing together, Lancet Neurol, 16, 333, 10.1016/S1474-4422(17)30086-8

Perrotta, 2016, Hypertension and dementia: epidemiological and experimental evidence revealing a detrimental relationship, Int J Mol Sci, 17, 347, 10.3390/ijms17030347

Bhat, 2015, Vasculoprotection as a convergent, multi-targeted mechanism of anti-AD therapeutics and interventions, J Alzheimers Dis, 46, 581, 10.3233/JAD-150098

Manukhina, 2016, Intermittent hypoxia training protects cerebrovascular function in Alzheimer's disease, Exp Biol Med, 241, 1351, 10.1177/1535370216649060

Leinenga, 2015, Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model, Sci Transl Med, 7, 278ra33, 10.1126/scitranslmed.aaa2512

Torrice, 2015, Alzheimer's therapy goes acoustic, Chem Eng News, 93, 5, 10.1021/cen-09311-notw4

Lammers, 2015, Theranostic USPIO-loaded microbubbles for mediating and monitoring blood-brain barrier permeation, Adv Funct Mater, 25, 36, 10.1002/adfm.201401199

Marquet, 2011, Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo, PLoS One, 6, e22598, 10.1371/journal.pone.0022598

Goliaei, 2015, Opening of the blood-brain barrier tight junction due to shock wave induced bubble collapse: a molecular dynamics simulation study, ACS Chem Neurosci, 10.1021/acschemneuro.5b00116

Adhikari, 2015, Mechanism of membrane poration by shock wave induced nanobubble collapse: a molecular dynamics study, J Phys Chem B, 119, 6225, 10.1021/acs.jpcb.5b02218

D'Arrigo, 2011

Kahlil, 2012, Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease, Mech Ageing Dev, 133, 20, 10.1016/j.mad.2011.11.008

Thanopoulou, 2010, Scavenger receptor classB type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model, Proc Natl Acad Sci U S A, 107, 20816, 10.1073/pnas.1005888107

Donev, 2009, Neuronal death in Alzheimer's disease and therapeutic opportunities, J Cell Mol Med, 13, 4329, 10.1111/j.1582-4934.2009.00889.x

Bredesen, 2014, Reversal of cognitive decline: a novel therapeutic program, Aging (Albany NY), 6, 707, 10.18632/aging.100690

Ho, 1997, Evaluation of lipid-coated microbubbles as a delivery vehicle for Taxol in tumor therapy, Neurosurgery, 40, 1260, 10.1097/00006123-199706000-00028

Wakefield, 1998, The use of lipid-coated microbubbles as a delivery agent for 7β-hydroxycholesterol to a radiofrequency lesion in the rat brain, Neurosurgery, 42, 592, 10.1097/00006123-199803000-00029

Jiao, 2015, Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits, Proc Natl Acad Sci U S A, 112, 5225, 10.1073/pnas.1422998112

Yang, 2015, Edaravone injection ameliorates cognitive deficits in rat model of Alzheimer's disease, Neurol Sci, 36, 2067, 10.1007/s10072-015-2314-y

Chen, 2010, Caffeine protects against disruptions of the blood-brain barrier in animal models of Alzheimer's and Parkinson's disease, J Alzheimers Dis, 20, S127, 10.3233/JAD-2010-1376

Chieffi, 2011, Caffeine protection against β-amyloid peptide toxicity in Alzheimer's disease, Curr Top Peptide Protein Res, 12, 71

Marques, 2011, Modulating Alzheimer's disease through caffeine: a putative link to epigenetics, J Alzheimers Dis, 24, 161, 10.3233/JAD-2011-110032

Mohan, 2015, Caffeine as treatment for Alzheimer's disease: a review, J Caffeine Res, 10.1089/jcr.2014.0027

Turner, 2015, A randomized, placebo-controlled trial of resveratrol for Alzheimer disease, Neurology, 85, 1383, 10.1212/WNL.0000000000002035

Zhao, 2015, Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood-brain barrier in AD rats, Neuroscience, 310, 641, 10.1016/j.neuroscience.2015.10.006

Hjorth, 2013, Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 human microglia and decrease inflammatory markers, J Alzheimers Dis, 35, 697, 10.3233/JAD-130131

Mayurasakorn, 2016, Ten VS. DHA but not EPA emulsions preserve neurological and mitochondrial function after brain hypoxia-ischemia in neonatal mice, PLoS One, 11, e0160870, 10.1371/journal.pone.0160870

Pan, 2015, The impact of docosahexaenoic acid on Alzheimer's disease: is there a role of the blood-brain barrier?, Curr Clin Pharmacol, 10, 222, 10.2174/157488471003150820151532

Vandal, 2014, Reduction in DHA transport to the brain of mice expressing human ApoE4 compared to ApoE2, J Neurochem, 129, 516, 10.1111/jnc.12640

Williams, 2013, N−3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice, PLoS One, 8, e56233, 10.1371/journal.pone.0056233

Yassine, 2016, Association of serum docosahexaenoic acid with cerebral amyloidosis, JAMA Neurol, 10.1001/jamaneurol.2016.1924

Orsini, 2014, Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis, Front Cell Neurosci, 10.3389/fncel.2014.00380

Savage, 2012, NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury, Front Immunol, 3, 288, 10.3389/fimmu.2012.00288

Baranova, 2005, Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases, J Biol Chem, 280, 8031, 10.1074/jbc.M405009200

Vishnyakova, 2003, Binding and internalization of lipopolysaccharide by CLA-1, a human orthologue of rodent scavenger receptor B1, J Biol Chem, 278, 22771, 10.1074/jbc.M211032200

Darlington, 2015, Human umbilical cord blood-derived monocytes improve cognitive deficits and reduce amyloid-β pathology in PSAPP mice, Cell Transplant, 24, 2237, 10.3727/096368915X688894

Chang, 2009, Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition, Neurobiol Aging, 30, 407, 10.1016/j.neurobiolaging.2007.07.006

Das, 2015, Amyloid-forming properties of human apolipoproteins: sequence analyses and structural insights, Adv Exp Med Biol, 855, 175, 10.1007/978-3-319-17344-3_8

Wang, 2011, Free-radicle scavenger Edaravone treatment confers neuroprotection against traumatic brain injury in rats, J Neurotrauma, 28, 2123, 10.1089/neu.2011.1939

Itoh, 2010, Edaravone protects against apoptotic neuronal cell death and improves cerebral function after traumatic brain injury in rats, Neurochem Res, 35, 348, 10.1007/s11064-009-0061-2

Mahringer, 2012, Overcoming the blood brain barrier: the challenge of brain drug targeting, J Nanoneurosci, 2, 5, 10.1166/jns.2012.1012

Raymond, 2008, Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models, PLoS One, 3, e2175, 10.1371/journal.pone.0002175

Choi, 2010, Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo, Ultrasound Med Biol, 36, 58, 10.1016/j.ultrasmedbio.2009.08.006

Timbie, 2015, Drug and gene delivery across the blood-brain barrier with focused ultrasound, J Control Release, 219, 61, 10.1016/j.jconrel.2015.08.059

Greene, 2016, Tight junction modulation of the blood-brain barrier: CNS delivery of small molecules, Tissue Barriers, 4, e1138017, 10.1080/21688370.2015.1138017

Sheikov, 2004, Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles, Ultrasound Med Biol, 30, 979, 10.1016/j.ultrasmedbio.2004.04.010

Walker, 2015, Development of food-grade nanoemulsions and emulsions for delivery of omega-3 fatty acids: opportunities and obstacles in the food industry, Food Funct, 6, 42, 10.1039/C4FO00723A

Keaney, 2015, Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier, Sci Adv, 1, e1500472, 10.1126/sciadv.1500472

Krstic, 2013, Deciphering the mechanism underlying late-onset Alzheimer's disease, Nat Rev Neurol, 9, 25, 10.1038/nrneurol.2012.236

Srimanee, 2016, Role of scavenger receptors in peptide-based delivery of plasmid DNA across a blood-brain barrier model, Int J Pharm, 500, 128, 10.1016/j.ijpharm.2016.01.014

Almer, 2015, Lipoprotein-related and apolipoprotein-mediated delivery systems for drug targeting and imaging, Curr Med Chem, 22, 3631, 10.2174/0929867322666150716114625

Lajoie, 2015, Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier, Annu Rev Pharmacol Toxicol, 55, 613, 10.1146/annurev-pharmtox-010814-124852

Preston, 2014, Transcytosis of macromolecules at the blood-brain barrier, Adv Pharmacol, 71, 147, 10.1016/bs.apha.2014.06.001

Carradori, 2016, Application of nanomedicine to the CNS diseases, Int Rev Neurobiol, 130, 73, 10.1016/bs.irn.2016.06.002

Di Marco, 2015, Vascular dysfunction in the pathogenesis of Alzheimer's disease — a review of endothelium-mediated mechanisms and ensuing vicious circles, Neurobiol Dis, 82, 593, 10.1016/j.nbd.2015.08.014

Koizumi, 2016, Endothelial dysfunction and amyloid-β-induced neurovascular alterations, Cell Mol Neurobiol, 36, 155, 10.1007/s10571-015-0256-9

Koster, 2016, Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro, J Cereb Blood Flow Metab, 36, 1865, 10.1177/0271678X16669956

Qosa, 2016, High-throughput screening for identification of blood-brain barrier integrity enhancers: a drug repurposing opportunity to rectify vascular amyloid toxicity, J Alzheimers Dis, 53, 1499, 10.3233/JAD-151179

Salmina, 2010, Endothelial dysfunction and repair in Alzheimer-type neurodegeneration: neuronal and glial control, J Alzheimers Dis, 22, 17, 10.3233/JAD-2010-091690

Tong, 2015, Simvastatin restored vascular reactivity, endothelial function and reduced string vessel pathology in a mouse model of cerebrovascular disease, J Cereb Blood Flow Metab, 35, 512, 10.1038/jcbfm.2014.226

Zenaro, 2016, The blood-brain barrier in Alzheimer's disease, Neurobiol Dis

Hottman, 2014, HDL and cognition in neurodegenerative disorders, Neurobiol Dis, 72, 22, 10.1016/j.nbd.2014.07.015

Velagapudi, 2017, VEGF-A regulates cellular localization of SR-BI as well as tansendothelial transport of HDL but not LDL, Arterioscler Thromb Vasc Biol, 37, 794, 10.1161/ATVBAHA.117.309284

Beishon, 2017, Cerebral hemodynamics in mild cognitive impairment: a systematic review, J Alzheimers Dis, 10.3233/JAD-170181

Goldwaser, 2016, Breakdown of the cerebrovasculature and blood-brain barrier: a mechanistic link between diabetes mellitus and Alzheimer's disease, J Alzheimers Dis, 54, 445, 10.3233/JAD-160284

Hishikawa, 2016, Cognitive and affective functions in Alzheimer's disease patients with metabolic syndrome, Eur J Neurol, 23, 339, 10.1111/ene.12845

Kapasi, 2016, Vascular contributions to cognitive impairment, clinical Alzheimer's disease, and dementia in older persons, Biochim Biophys Acta, 1862, 878, 10.1016/j.bbadis.2015.12.023

Kelleher, 2013, Evidence of endothelial dysfunction in the development of Alzheimer's disease: is Alzheimer's a vascular disorder?, Am J Cardiovasc Dis, 3, 197

McAleese, 2016, Post-mortem assessment in vascular dementia: advances and aspirations, BMC Med, 14, 129, 10.1186/s12916-016-0676-5

Muche, 2017, Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells, PLoS One, 12, e0178127, 10.1371/journal.pone.0178127

Nelson, 2016, Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease, Biochim Biophys Acta, 1862, 887, 10.1016/j.bbadis.2015.12.016

Noh, 2016, The role of cerebrovascular disease in amyloid deposition, J Alzheimers Dis, 54, 1015, 10.3233/JAD-150832

Raz, 2016, The neuropathology and cerebrovascular mechanisms of dementia, J Cereb Blood Flow Metab, 36, 172, 10.1038/jcbfm.2015.164

Weekman, 2016, Reduced efficacy of anti-Aβ immunotherapy in a mouse model of amyloid deposition and vascular cognitive impairment comorbidity, J Neurosci, 36, 9896, 10.1523/JNEUROSCI.1762-16.2016

Calabrese, 2016, Major pathogenic mechanisms in vascular dementia: roles of cellular stress response and hormesis in neuroprotection, J Neurosci Res, 94, 1588, 10.1002/jnr.23925

Gutierrez, 2016, Brain arterial aging and its relationship to Alzheimer dementia, Neurology, 86, 1507, 10.1212/WNL.0000000000002590

Nagata, 2016, Cerebral circulation in aging, Ageing Res Rev, 30, 49, 10.1016/j.arr.2016.06.001

Toth, 2017, Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging, Am J Physiol Heart Circ Physiol, 312, H1, 10.1152/ajpheart.00581.2016

Austin, 2016, Loss of endothelial nitric oxide synthase promotes p25 generation and tau phosphorylation in a murine model of Alzheimer's disease, Circ Res, 119, 1128, 10.1161/CIRCRESAHA.116.309686

Devraj, 2016, BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease, J Cereb Blood Flow Metab, 36, 1281, 10.1177/0271678X15606463

Festoff, 2016, HGMB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease, J Neuroinflammation, 13, 194, 10.1186/s12974-016-0670-z

Gangoda, 2016, Pulsatile stretch alters expression and processing of amyloid precursor protein in human cerebral endothelial cells, J Hypertens, 34, e24, 10.1097/01.hjh.0000491393.79855.fc

Khalil, 2016, Linking multiple pathogenic pathways in Alzheimer's disease, World J Psychiatry, 6, 208, 10.5498/wjp.v6.i2.208

Roberts, 2016, Increased pulmonary arteriolar tone associated with lung oxidative stress and nitric oxide in a mouse model of Alzheimer's disease, Physiol Rep, 4, e12953, 10.14814/phy2.12953

Shang, 2016, Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice, J Cereb Blood Flow Metab, 36, 1978, 10.1177/0271678X16660983

Wang, 2017, Regulation of human brain microvascular endothelial cell adhesion and barrier functions by memantine, J Mol Neurosci, 62, 123, 10.1007/s12031-017-0917-x

Austin, 2015, Regional heterogeneity of cerebral microvessels and brain susceptibility to oxidative stress, PLoS One, 10, e0144062, 10.1371/journal.pone.0144062

Bogush, 2017, Blood brain barrier injury in diabetes: unrecognized effects on brain and cognition, J Neuroimmune Pharmacol, 10.1007/s11481-017-9752-7

Chao, 2016, Hyperglycemia increases the production of amyloid beta-peptide leading to decreased endothelial tight junction, CNS Neurosci Ther, 22, 291, 10.1111/cns.12503

Iadecola, 2016, Untangling neurons with endothelial nitric oxide, Circ Res, 119, 1052, 10.1161/CIRCRESAHA.116.309927

Kalaria, 2016, Stroke injury, cognitive impairment and vascular dementia, Biochim Biophys Acta, 1862, 915, 10.1016/j.bbadis.2016.01.015

Katusic, 2016, Neurovascular protective function of endothelial nitric oxide: recent advances, Circ J, 80, 1499, 10.1253/circj.CJ-16-0423

Khan, 2016, Update on vascular dementia, J Geriatr Psychiatry Neurol, 29, 281, 10.1177/0891988716654987

Kyrtsos, 2015, Modeling the role of the glymphatic pathway and cerebral blood vessel properties in Alzheimer's disease pathogenesis, PLoS One, 10, e0139574, 10.1371/journal.pone.0139574

Toda, 2016, Cigarette smoking impairs nitric oxide-mediated cerebral blood flow increase: implications for Alzheimer's disease, J Pharmacol Sci, 131, 223, 10.1016/j.jphs.2016.07.001

Uiterwijk, 2016, Endothelial activation is associated with cognitive performance in patients with hypertension, Am J Hypertens, 29, 464, 10.1093/ajh/hpv122

Vanhoutte, 2017, Endothelial dysfunction and vascular disease – a 30th anniversary update, Acta Physiol (Oxf), 219, 22, 10.1111/apha.12646

Wang, 2016, Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice, Exp Neurol, 283, 353, 10.1016/j.expneurol.2016.07.006

Scheibel, 1989, Alzheimer's disease as a capillary dementia, Ann Med, 21, 103, 10.3109/07853898909149194

Wang, 2017, Mitochondrial ferritin deletion exacerbates β-amyloid-induced neurotoxicity in mice, Oxid Med Cell Longev, 10.1155/2017/1020357

Sorop, 2017, The microcirculation: a key player in obesity-associated cardiovascular disease, Cardiovasc Res, 10.1093/cvr/cvx093

Wang, 2014, Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: a potential etiological linkage, Med Sci Monit Basic Res, 20, 118, 10.12659/MSMBR.891278

Armstrong, 2015, A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis, Cardiovasc Res, 108, 268, 10.1093/cvr/cvv218

Chakraborty, 2017, The blood-brain barrier in Alzheimer's disease, Vascul Pharmacol, 89, 12, 10.1016/j.vph.2016.11.008

Dalkara, 2015, Cerebral microvascular pericytes and neurogliovascular signaling in health and disease, Brain Res, 1623, 3, 10.1016/j.brainres.2015.03.047

Gocmez, 2016, Age impaired endothelium-dependent vasodilation is improved by resveratrol in rat mesenteric arteries, J Exerc Nutrition Biochem, 20, 41, 10.20463/jenb.2016.03.20.1.2

Giulia, 2015, Brain atrophy, anti-smooth muscle antibody and cognitive impairment: an association study, Aging Dis, 7, 318, 10.14336/AD.2015.1124

Li, 2017, Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia, Acta Biochim Biophys Sin Shanghai, 49, 83, 10.1093/abbs/gmw116

Pan, 2016, Fatty acid-binding protein 5 at the blood-brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function, J Neurosci, 36, 11755, 10.1523/JNEUROSCI.1583-16.2016

KW, 2016, Neurovascular coupling protects neurons against hypoxic injury via inhibition of potassium currents by generation of nitric oxide in direct neuron and endothelium cocultures, Neuroscience, 334, 275, 10.1016/j.neuroscience.2016.08.012

Belaidi, 2016, Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics, J Neurochem, 139, 179, 10.1111/jnc.13425

Beydoun, 2017, Na+/H+ exchanger 9 regulates iron mobilization at the blood-brain barrier in response to iron starvation, J Biol Chem, 10.1074/jbc.M116.769240

McCarthy, 2015, Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier, Front Mol Neurosci, 8, 31, 10.3389/fnmol.2015.00031

Pirpamer, 2016, Determinants if iron accumulation in the normal aging brain, Neurobiol Aging, 43, 149, 10.1016/j.neurobiolaging.2016.04.002

Simpson, 2015, A novel model for brain iron uptake: introducing the concept of regulation, J Cereb Blood Flow Metab, 35, 48, 10.1038/jcbfm.2014.168

Daulatzai, 2017, Cerebral hypoperfusion and glucose hypometabolism: key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease, J Neurosci Res, 95, 943, 10.1002/jnr.23777

Longden, 2016, Ion channel networks in the control of cerebral blood flow, J Cereb Blood Flow Metab, 36, 492, 10.1177/0271678X15616138

Eskildsen, 2017, Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study, Neurobiol Aging, 50, 107, 10.1016/j.neurobiolaging.2016.11.004

Love, 2017, Small vessel disease, neurovascular regulation and cognitive impairment: post-mortem studies reveal a complex relationship, still poorly understood, Clin Sci (Lond), 131, 1579, 10.1042/CS20170148

Bomboi, 2005, Correlation between metal ions and clinical findings in subjects affected by Alzheimer's disease, Ann 1st Super Sanita, 41, 205

Mattson, 2004, Metal-catalyzed disruption of membrane protein and lipid signaling in the pathogenesis of neurodegenerative disorders, Ann N Y Acad Sci, 1012, 37, 10.1196/annals.1306.004

Wan, 2011, β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease, Free Radic Biol Med, 50, 122, 10.1016/j.freeradbiomed.2010.10.707

Gerlach, 1994, Altered brain metabolism of iron as a cause of neurodegenerative diseases?, J Neurochem, 63, 793, 10.1046/j.1471-4159.1994.63030793.x

Everett, 2014, Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1–42), J R Soc Interface, 11, 20140165, 10.1098/rsif.2014.0165

Tonnies, 2017, Oxidative stress, synaptic dysfunction, and Alzheimer's disease, J Alzheimers Dis, 10.3233/JAD-161088

Kerr, 2017, Mitophagy and Alzheimer's disease: cellular and molecular mechanisms, Trends Neurosci, 10.1016/j.tins.2017.01.002

Barros, 2017, Near-critical GLUT1 and neurodegeneration, J Neurosci Res, 10.1002/jnr.23998

Jais, 2016, Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairmentin obesity, Cell, 165, 882, 10.1016/j.cell.2016.03.033

Keaney, 2015, The dynamic blood-brain barrier, FEBS J, 282, 4067, 10.1111/febs.13412

Harik, 1992, Changes in the glucose transporter of brain capillaries, Can J Physiol Pharmacol, 70, S113, 10.1139/y92-252

Winkler, 2015, GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration, Nat Neurosci, 18, 521, 10.1038/nn.3966

Yoon, 2017, Circulating cellular adhesion molecules and cognitive function: the coronary artery risk development in young adults study, Front Cardiovasc Med, 10.3389/fcvm.2017.00037

Lourenco, 2017, Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: impaired cerebral blood flow response to neuronal-derived nitric oxide signaling, Exp Neurol, 291, 36, 10.1016/j.expneurol.2017.01.013

Castillo-Carranza, 2017, Cerebral microvascular accumulation of tau oligomers in Alzheimer's disease and related tauopathies, Aging Dis, 8, 257, 10.14336/AD.2017.0112

Dudvarski Stankovic, 2016, Microglia-blood vessel interactions: a double-edged sword in brain pathologies, Acta Neuropathol, 131, 347, 10.1007/s00401-015-1524-y

Michalicova, 2017, Tauopathies – focus on changes at the neurovascular unit, Curr Alzheimer Res, 10.2174/1567205014666170203143336

Lee, 2017, Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress, Am J Physiol Cell Physiol, 312, C500, 10.1152/ajpcell.00120.2016

Stukas, 2014, High-density lipoproteins and cerebrovascular integrity in Alzheimer's disease, Cell Metab, 19, 574, 10.1016/j.cmet.2014.01.003

Choi, 2016, Amyloid-independent amnestic mild cognitive impairment and serum apolipoprotein A1 levels, Am J Geriatr Psychiatry, 24, 144, 10.1016/j.jagp.2015.06.004

Kitamura, 2017, Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease, Neurol Res, 39, 231, 10.1080/01616412.2017.1281195

Lazarus, 2015, DNA methylation in the apolipoprotein-A1 gene is associated with episodic memory performance on healthy older individuals, J Alzheimers Dis, 44, 175, 10.3233/JAD-141314

Ma, 2015, Serum levels of apo A1 and apo A2 are associated with cognitive status in older men, Biomed Res Int, 2015, 481621, 10.1155/2015/481621

Slot, 2017, Apolipoprotein A1 in cerebrospinal fluid and plasma and progression to Alzheimer's disease in non-demented elderly, J Alzheimers Dis, 56, 687, 10.3233/JAD-151068

Yin, 2014, Inverse relationship between apolipoprotein A-I and cerebral white matter lesions: a cross-sectional study in middle-aged and elderly subjects, PLoS One, 9, e97113, 10.1371/journal.pone.0097113

D'Arrigo, 1991, Lipid-coated uniform microbubbles for earlier sonographic detection of brain tumors, J Neuroimaging, 1, 134, 10.1111/jon199113134

D'Arrigo, 1993, Detection of experimental rat liver tumors by contrast-assisted ultrasonography, Invest Radiol, 28, 218, 10.1097/00004424-199303000-00006

Simon, 1990, Lipid-coated ultrastable microbubbles as a contrast agent in neurosonography, Invest Radiol, 25, 1300, 10.1097/00004424-199012000-00005

Simon, 1992, Quantitative assessment of tumor enhancement by ultrastable lipid-coated microbubbles as a sonographic contrast agent, Invest Radiol, 27, 29, 10.1097/00004424-199201000-00003

Ho, 1997, The affinity of lipid-coated microbubbles for maturing brain injury sites, Brain Res Bull, 43, 543, 10.1016/S0361-9230(96)00435-2

Kureshi, 1999, The affinity of lipid-coated microbubbles to maturing spinal cord injury sites, Neurosurgery, 44, 1047, 10.1097/00006123-199905000-00059

1. D'Arrigo J. Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures. 1987

2. United States Patent No. 4,684,479 (issued 1987).

Huang, 1993, Use of lipid-coated microbubbles (LCMs) for susceptibility-based MRI contrast in brain tumors

Skachkov, 2014, Targeted microbubble mediated sonoporation of endothelial cells in vivo, IEEE Trans Ultrason Ferroelectr Freq Control, 61, 1661, 10.1109/TUFFC.2014.006440

Caskey, 2007, Direct observations of ultrasound microbubble contrast agant interaction with the microvessel wall, J Acoust Soc Am, 122, 1191, 10.1121/1.2747204

Choi, 2008, Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound, Ultrason Imaging, 30, 189, 10.1177/016173460803000304

Choi, 2011, Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles, Proc Natl Acad Sci U S A, 108, 16539, 10.1073/pnas.1105116108

Konofagou, 2012, Optimization of the ultrasound-induced blood-brain barrier opening, Theranostics, 2, 1223, 10.7150/thno.5576

McDannold, 2012, Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluatiopn in rhesus macaques, Cancer Res, 72, 3652, 10.1158/0008-5472.CAN-12-0128

Raymond, 2007, Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo, J Cereb Blood Flow Metab, 27, 393, 10.1038/sj.jcbfm.9600336

Xie, 2008, Effects of transcranial ultrasound and intravenous microbubbles on blood brain barrier permeability in a large animal model, Ultrasound Med Biol, 34, 2028, 10.1016/j.ultrasmedbio.2008.05.004

Dasgupta, 2016, Ultrasound-mediated drug delivery to the brain: principles, progress and prospects, Drug Discov Today Technol, 20, 41, 10.1016/j.ddtec.2016.07.007

Helfield, 2016, Biophysical insight into mechanisms of sonoporation, Proc Natl Acad Sci, 113, 9983, 10.1073/pnas.1606915113

De Cock, 2015, Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis, J Control Release, 197, 20, 10.1016/j.jconrel.2014.10.031

Andreone, 2017, Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis, Neuron, 10.1016/j.neuron.2017.03.043

Ben-Zvi, 2014, MFSD2A is critical for the formation and function of the blood-brain barrier, Nature, 509, 507, 10.1038/nature13324

Aw, 2016, The progressive role of acoustic cavitation for non-invasive therapies, contrast imaging and blood-tumor permeability enhancement, Expert Opin Drug Deliv, 13, 1383, 10.1080/17425247.2016.1192123

Park, 2010, Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation, Ultrasound Med Biol, 36, 1176, 10.1016/j.ultrasmedbio.2010.04.006

Alonso, 2010, Reorganization of gap junctions after focused ultrasound blood-brain barrier opening in the rat brain, J Cereb Blood Flow Metab, 30, 1394, 10.1038/jcbfm.2010.41

Alonso, 2011, Clearance of albumin following ultrasound-induced blood-brain barrier opening is mediated by glial but not neuronal cells, Brain Res, 1411, 9, 10.1016/j.brainres.2011.07.006

Aslund, 2017, Efficient enhancement of blood-brain barrier permeability using acoustic cluster therapy (ACT), Theranostics, 7, 23, 10.7150/thno.16577

D'Arrigo, 2015, Nanotherapy for Alzheimer's, Chem Eng News, 93, 2

Kotopoulis, 2013, Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study, Med Phys, 40, 072902, 10.1118/1.4808149

Kotopoulis, 2014, Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft, Mol Imaging Biol, 16, 53, 10.1007/s11307-013-0672-5

Meairs, 2015, Facilitation of drug transport across the blood-brain barrier with ultrasound and microbubbles, Pharmaceutics, 7, 275, 10.3390/pharmaceutics7030275

Meng, 2017, Focused US as a novel strategy for Alzheimer's disease therapeutics, Ann Neurol, 10.1002/ana.24933

Aubry, 2016, MR-guided transcranial focused ultrasound, Adv Exp Med Biol, 880, 97, 10.1007/978-3-319-22536-4_6

Bouakaz, 2016, Sonoporation: concept and mechanisms, Adv Exp Med Biol, 880, 175, 10.1007/978-3-319-22536-4_10

Burgess, 2016, Microbubble-assisted ultrasound for drug delivery in the brain and central nervous system, Adv Exp Med Biol, 880, 293, 10.1007/978-3-319-22536-4_16

Castle, 2016, Drug and gene delivery using sonoporation for cardiovascular disease, Adv Exp Med Biol, 880, 331, 10.1007/978-3-319-22536-4_18

Delalande, 2015, Efficient gene delivery by sonoporation is associated with microbubble entry into cells and the clathrin-dependent endocytosis pathway, Ultrasound Med Biol, 41, 1913, 10.1016/j.ultrasmedbio.2015.03.010

O'Reilly, 2017, Blood-brain barrier closure time after controlled ultrasound-induced opening is independent of opening volume, J Ultrasound Med, 36, 475, 10.7863/ultra.16.02005

Qin, 2016, Sonoporation: applications for cancer therapy, Adv Exp Med Biol (Therapeutic Ultrasound), 880, 263, 10.1007/978-3-319-22536-4_15