Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

Alzheimer's & Dementia - Tập 13 - Trang 1143-1153 - 2017
Rune B. Nielsen1, Lærke Egefjord2, Hugo Angleys1, Kim Mouridsen1, Michael Gejl2,3, Arne Møller4, Birgitte Brock2,3, Hans Brændgaard5, Hanne Gottrup5, Jørgen Rungby6, Simon F. Eskildsen1, Leif Østergaard1,7
1Center of Functionally Integrative Neuroscience and MINDLab, Aarhus University, Aarhus, Denmark
2Department of Biomedicine, Aarhus University, Aarhus, Denmark
3Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark
4PET-Center, Department of Nuclear Medicine, Aarhus University Hospital, Aarhus, Denmark
5Dementia Clinic, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark
6Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, Denmark
7Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark

Tóm tắt

AbstractIntroductionWe examined whether cortical microvascular blood volume and hemodynamics in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate with cognitive performance and the degree of cortical thinning.MethodsThirty‐two AD patients underwent cognitive testing, structural magnetic resonance imaging (MRI), and perfusion MRI at baseline and after 6 months. We measured cortical thickness, microvascular cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and capillary transit time heterogeneity (CTH) and estimated tissue oxygen tension (PtO2).ResultsAt baseline, poor cognitive performance and regional cortical thinning correlated with lower CBF and CBV, with higher MTT and CTH and with low PtO2 across the cortex. Cognitive decline over time was associated with increasing whole brain relative transit time heterogeneity (RTH = CTH/MTT).DiscussionOur results confirm the importance of microvascular pathology in AD. Deteriorating microvascular hemodynamics may cause hypoxia, which is known to precipitate amyloid retention.

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Alzheimer's & Dementia

Tập 13

1143-1153

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