Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases

Molecular Brain - Tập 9 - Trang 1-8 - 2016
Jinqiang Zhu1,2, Wanshan Song3, Lin Li1,2, Xiang Fan1,2
1State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China
2Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Nankai District, P. R. China
3Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, P. R. China

Tóm tắt

Endothelial nitric oxide (NO) is a significant signaling molecule that regulates cerebral blood flow (CBF), playing a pivotal role in the prevention and treatment of cerebrovascular diseases. However, achieving the expected therapeutic efficacy is difficult using direct administration of NO donors. Therefore, endothelial nitric oxide synthase (eNOS) becomes a potential therapeutic target for cerebrovascular diseases. This review summarizes the current evidence supporting the importance of CBF to cerebrovascular function, and the roles of NO and eNOS in CBF regulation.

Tài liệu tham khảo

Thông tin
Thông tin xuất bản

Molecular Brain

Tập 9

1-8

Thông tin tác giả