Targeted delivery of antibodies through the blood–brain barrier by MRI-guided focused ultrasound

Pardridge, 2002, Drug and gene delivery to the brain: the vascular route, Neuron, 36, 555, 10.1016/S0896-6273(02)01054-1 Abbott, 1996, Transporting therapeutics across the blood–brain barrier, Mol. Med. Today, 2, 106, 10.1016/1357-4310(96)88720-X Laske, 1997, Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors, Nat. Med., 3, 1362, 10.1038/nm1297-1362 Weaver, 2003, Transferrin receptor ligand-targeted toxin conjugate (Tf-CRM107) for therapy of malignant gliomas, J. Neurooncol., 65, 3, 10.1023/A:1026246500788 Pardridge, 2002, Drug and gene targeting to the brain with molecular Trojan horses, Nat. Rev. Drug Discov., 1, 131, 10.1038/nrd725 Pardridge, 2003, Blood–brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain, Curr. Opin. Drug Discov. Dev., 6, 683 Schwarze, 1999, In vivo protein transduction: delivery of a biologically active protein into the mouse, Science, 285, 1569, 10.1126/science.285.5433.1569 Kroll, 1998, Outwitting the blood–brain barrier for therapeutic purposes: osmotic opening and other means, Neurosurgery, 42, 1083, 10.1097/00006123-199805000-00082 Doolittle, 2000, Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood–brain barrier for the treatment of patients with malignant brain tumors, Cancer, 88, 637, 10.1002/(SICI)1097-0142(20000201)88:3<637::AID-CNCR22>3.0.CO;2-Y Tempany, 2003, MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study, Radiology, 226, 897, 10.1148/radiol.2271020395 Hynynen, 2001, MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study, Radiology, 219, 176, 10.1148/radiology.219.1.r01ap02176 Kinoshita, 2005, A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound, Biochem. Biophys. Res. Commun., 335, 393, 10.1016/j.bbrc.2005.07.101 Hynynen, 2001, Noninvasive MR imaging-guided focal opening of the blood–brain barrier in rabbits, Radiology, 220, 640, 10.1148/radiol.2202001804 Hynynen, 2003, Non-invasive opening of BBB by focused ultrasound, Acta Neurochir. Suppl., 86, 555 Hynynen, 2005, Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications, Neuroimage, 24, 12, 10.1016/j.neuroimage.2004.06.046 McDannold, 2004, MRI investigation of the threshold for thermally induced blood–brain barrier disruption and brain tissue damage in the rabbit brain, Magn. Reson. Med., 51, 913, 10.1002/mrm.20060 Sheikov, 2004, Cellular mechanisms of the blood–brain barrier opening induced by ultrasound in presence of microbubbles, Ultrasound Med. Biol., 30, 979, 10.1016/j.ultrasmedbio.2004.04.010 Vykhodtseva, 1995, Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo, Ultrasound Med. Biol., 21, 969, 10.1016/0301-5629(95)00038-S McDannold, 2003, MRI-guided focused ultrasound surgery in the brain: tests in a primate model, Magn. Reson. Med., 49, 1188, 10.1002/mrm.10453 Wedzony, 2000, Cortical localization of dopamine D4 receptors in the rat brain–immunocytochemical study, J. Physiol. Pharmacol., 51, 205 Hynynen, 1997, Thermal effects of focused ultrasound on the brain: determination with MR imaging, Radiology, 204, 247, 10.1148/radiology.204.1.9205255 Defagot, 1997, Distribution of D4 dopamine receptor in rat brain with sequence-specific antibodies, Brain Res. Mol. Brain Res., 45, 1, 10.1016/S0169-328X(96)00235-5 Bell, 2002, What can we learn from Herceptin trials in metastatic breast cancer?, Oncology, 63, 39, 10.1159/000066200 Maloney, 1998, Newer treatments for non-Hodgkin’s lymphoma: monoclonal antibodies, Oncology (Williston Park), 12, 63 Janus, 2000, A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease, Nature, 408, 979, 10.1038/35050110 Klyubin, 2005, Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo, Nat. Med., 11, 556, 10.1038/nm1234 Rubenstein, 2003, Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment, Blood, 101, 466, 10.1182/blood-2002-06-1636