Plasma levels of soluble amyloid precursor protein β in symptomatic Alzheimer’s disease

Springer Science and Business Media LLC - Tập 268 - Trang 519-524 - 2017
Panagiotis Alexopoulos1,2, Lena-Sophie Gleixner1, Lukas Werle1,3, Felix Buhl1, Nathalie Thierjung1, Evangelia Giourou2, Simone M. Kagerbauer4, Philippos Gourzis2, Hubert Kübler5, Timo Grimmer1, Igor Yakushev6, Jan Martin4, Alexander Kurz1, Robert Perneczky7,8,9,10
1Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
2Department of Psychiatry, University Hospital of Rion, University of Patras, Patras, Greece
3Max Planck Institute of Psychiatry, Munich, Germany
4Department of Anaesthesiology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany
5Department of Urology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
6Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
7Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität München, Munich, Germany
8Neuroepidemiology and Ageing Research Unit, Faculty of Medicine, School of Public Health, The Imperial College of Science, Technology and Medicine, London, UK
9West London Mental Health NHS Trust, London, UK
10German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

Tóm tắt

The established biomarkers of Alzheimer’s disease (AD) require invasive endeavours or presuppose sophisticated technical equipment. Consequently, new biomarkers are needed. Here, we report that plasma levels of soluble amyloid precursor protein β (sAPPβ), a protein of the initial phase of the amyloid cascade, were significantly lower in patients with symptomatic AD (21 with mild cognitive impairment due to AD and 44 with AD dementia) with AD-typical cerebral hypometabolic pattern compared with 27 cognitively healthy elderly individuals without preclinical AD. These findings yield further evidence for the potential of sAPPβ in plasma as an AD biomarker candidate.

Tài liệu tham khảo

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