Hybrid materials with continuous mechanical property gradients that can be 3D printed

Nesti, 2008, Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam, Tissue Eng., 14, 1527, 10.1089/ten.tea.2008.0215

Gwynne, 2010, Preparation of polymeric samples containing a graduated modulus region and development of nanoindentation linescan techniques, Polym. Test., 29, 494, 10.1016/j.polymertesting.2010.02.010

Zinkovska, 2020, Gradient hydrogels — the state of the art in preparation methods, Polymers, 12, 966, 10.3390/polym12040966

Li, 2019, Buoyancy-driven gradients for biomaterial fabrication and tissue engineering, Adv Mater, 31

Banik, 2012, A new approach for creating polymer hydrogels with regions of distinct chemical, mechanical, and optical properties, Macromolecules, 45, 5712, 10.1021/ma300859b

Wong, 2003, Directed movement of vascular smooth muscle cells on gradient-compliant hydrogels, Langmuir, 19, 1908, 10.1021/la026403p

Gharazi, 2018, Nature-inspired hydrogels with soft and stiff zones that exhibit a 100-fold difference in elastic modulus, ACS Appl. Mater. Interfaces, 10, 34664, 10.1021/acsami.8b14126

Mohammed, 2019, Open vessel free radical photopolymerization of double network gels for biomaterial applications using glucose oxidase, J. Mater. Chem. B., 7, 4030, 10.1039/C9TB00658C

Mohammed, 2020, Auto-catalytic redox polymerisation using nanoceria and glucose oxidase for double network hydrogels, J. Mater. Chem. B., 8, 2834, 10.1039/C9TB02729G

Gong, 2003, Double-network hydrogels with extremely high mechanical strength, Adv. Mater., 15, 1155, 10.1002/adma.200304907

Haque, 2012, Super tough double network hydrogels and their application as biomaterials, Polymer (Guildf), 53, 1805, 10.1016/j.polymer.2012.03.013

Migacz, 2014, Gradient composite materials for artificial intervertebral discs, Acta Bioeng. Biomech., 16, 3

Spinnrock, 2019, Controlled preparation of nanoparticle gradient materials by diffusion, Nanomaterials, 9, 10.3390/nano9070988

Novak, 1993, Hybrid nanocomposite materials - between inorganic glasses and organic polymers, Adv. Mater., 5, 10.1002/adma.19930050603

Sanchez, 2011, Applications of advanced hybrid organic-inorganic nanomaterials: from laboratory to market, Chem. Soc. Rev., 40, 696, 10.1039/c0cs00136h

Mahony, 2010, Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration, Adv. Funct. Mater., 20, 3835, 10.1002/adfm.201000838

Tsuru, 2004, Synthesis of bioactive and porous organic-inorganic hybrids for biomedical applications, J. Sol. Gel Sci. Technol., 32, 201, 10.1007/s10971-004-5789-1

Connell, 2014, Chemical characterisation and fabrication of chitosan–silica hybrid scaffolds with 3-glycidoxypropyl trimethoxysilane, J. Mater. Chem. B., 2, 668, 10.1039/C3TB21507E

Shirosaki, 2008, Synthesis and cytocompatibility of porous chitosan-silicate hybrids for tissue engineering scaffold application, Chem. Eng. J., 137, 122, 10.1016/j.cej.2007.10.012

Poologasundarampillai, 2010, Synthesis of bioactive class II poly(γ-glutamic acid)/silica hybrids for bone regeneration, J. Mater. Chem., 20, 8952, 10.1039/c0jm00930j

Jones, 2013, Review of bioactive glass: from Hench to hybrids, Acta Biomater., 9, 4457, 10.1016/j.actbio.2012.08.023

Tallia, 2018, Bouncing and 3D printable hybrids with self-healing properties, Mater, Horizons, 5, 849

Deng, 2020, Green synthesis and biomedical properties of novel hydroxypropyl cellulose-g-polytetrahydrofuran graft copolymers with silver nanoparticles, Ind. Eng. Chem. Res., 59, 732, 10.1021/acs.iecr.9b04799

Kamitakahara, 2007, Preparation of bioactive flexible poly(tetramethylene oxide) (PTMO)-CaO-Ta2O5 hybrids, J. Mater. Sci. Mater. Med., 18, 1117, 10.1007/s10856-007-0147-9

Fan, 2022, Resolving the conflict between strength and toughness in bioactive silica–polymer hybrid materials, ACS Nano, 10.1021/acsnano.2c03440

Aghayan, 2021, Multifunctional polyethylene imine hybrids decorated by silica bioactive glass with enhanced mechanical properties, antibacterial, and osteogenesis for bone repair, Mater. Sci. Eng. C., 131, 10.1016/j.msec.2021.112534

Fan, 2021, Structural control of self-healing silica–poly(tetrahydropyran)–poly(ε-caprolactone) hybrids, J. Mater. Chem. B., 9, 4400, 10.1039/D1TB00555C

Chung, 2016, Tailoring mechanical properties of sol–gel hybrids for bone regeneration through polymer structure, Chem. Mater., 28, 6127, 10.1021/acs.chemmater.6b01941

Miyata, 2002, Apatite-forming ability and mechanical properties of PTMO-modified CaO–SiO2 hybrids prepared by sol–gel processing: effect of CaO and PTMO contents, Biomaterials, 23, 10.1016/S0142-9612(02)00065-0

Sang, 2018, Hybrids of Silica/Poly(caprolactone coglycidoxypropyl trimethoxysilane) as Biomaterials, Chem. Mater., 30, 3743, 10.1021/acs.chemmater.8b00751

Ferreira, 2018, Bi-directional cell-pericellular matrix interactions direct stem cell fate, Nat. Commun., 9, 4049, 10.1038/s41467-018-06183-4

Ferreira, 2018, Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence, Biomaterials, 176, 13, 10.1016/j.biomaterials.2018.05.032

Tian, 1998, Biodegradable and biocompatible inorganic-organic hybrid materials 2. Dynamic mechanical properties, structure and morphology, Polymer (Guildf), 39, 855, 10.1016/S0032-3861(97)00343-1

Fulmer, 2010, NMR chemical shifts of trace impurities: common laboratory solvents, organics, and gases in deuterated solvents relevant to the organometallic chemist, Organometallics, 29, 2176, 10.1021/om100106e

Macon, 2015, A structural and physical study of sol-gel methacrylate-silica hybrids: intermolecular spacing dictates the mechanical properties, Phys. Chem. Chem. Phys., 17, 29124, 10.1039/C5CP04656D

Poologasundarampillai, 2014, Poly(gamma-glutamic acid)/silica hybrids with calcium incorporated in the silica network by use of a calcium alkoxide precursor, Chem. Eur J., 20, 8149, 10.1002/chem.201304013

Lee, 2003, The mechanical properties of the SiOC(-H) composite thin films with a low dielectric constant, Surf. Coating. Technol., 171, 296, 10.1016/S0257-8972(03)00289-5

Zhang, 2007, Structural characterization of sol–gel composites using TEOS/MEMO as precursors, Surf. Coating. Technol., 201, 6051, 10.1016/j.surfcoat.2006.11.012

Tienen, 2006, Replacement of the knee meniscus by a porous polymer implant: a study in dogs, Am. J. Sports Med., 34, 64, 10.1177/0363546505280905