Anti-cancer effects of ethanol extract of Reynoutria japonica Houtt. radix in human hepatocellular carcinoma cells via inhibition of MAPK and PI3K/Akt signaling pathways

Journal of Ethnopharmacology - Tập 245 - Trang 112179 - 2019
Ba Reum Kim1, Jain Ha1, Sewoong Lee1, Jiyoung Park1, Sayeon Cho1
1Laboratory of Molecular and Pharmacological Cell Biology, College of Pharmacy, Chung-Ang University, Seoul, 06974, South Korea

Tài liệu tham khảo

El–Serag, 2007, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, 132, 2557, 10.1053/j.gastro.2007.04.061

Chan, 2008, Antioxidant activity of Chinese medicinal herbs, Pharm. Biol., 46, 587, 10.1080/13880200802179667

Chang, 2012, Transcriptional repression of TWIST1 gene by Prospero‐related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells, FEBS Lett., 586, 3746, 10.1016/j.febslet.2012.08.034

Chen, 2012, Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer, Carcinogenesis, 34, 10, 10.1093/carcin/bgs274

Chen, 2012, The significance of MMP-9 over MMP-2 in HCC invasiveness and recurrence of hepatocellular carcinoma after curative resection, Ann. Surg. Oncol., 19, 375, 10.1245/s10434-011-1836-7

Cheng, 2006, Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-κB signal transduction pathway, Oncogene, 25, 7009, 10.1038/sj.onc.1209706

Cheng, 2008, Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function, J. Biol. Chem., 283, 14665, 10.1074/jbc.M707429200

Cho, 2008, Expression of E‐and N‐cadherin and clinicopathology in hepatocellular carcinoma, Pathol. Int., 58, 635, 10.1111/j.1440-1827.2008.02282.x

Chung, 2004, Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential, FASEB J., 18, 1123, 10.1096/fj.03-1429fje

Costa, 2016, 3D tumor spheroids: an overview on the tools and techniques used for their analysis, Biotechnol. Adv., 34, 1427, 10.1016/j.biotechadv.2016.11.002

De Craene, 2005, Unraveling signalling cascades for the Snail family of transcription factors, Cell. Signal., 17, 535, 10.1016/j.cellsig.2004.10.011

Deng, 2017, The anti-tumor activities of Neferine on cell invasion and oxaliplatin sensitivity regulated by EMT via Snail signaling in hepatocellular carcinoma, Sci. Rep., 7, 41616, 10.1038/srep41616

Ding, 2005, Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin, Mol. Cell, 19, 159, 10.1016/j.molcel.2005.06.009

Dreesen, 2007, Signaling pathways in cancer and embryonic stem cells, Stem Cell Rev., 3, 7, 10.1007/s12015-007-0004-8

Feng, 2006, Studies on active substance of anticancer effect in Polygonum cuspidatum, Zhong Yao Cai Zhongyaocai J. Chin. Med. Mater., 29, 689

Finn, 2010, Development of molecularly targeted therapies in hepatocellular carcinoma: where do we go now?, Clin. Cancer Res., 16, 390, 10.1158/1078-0432.CCR-09-2084

Friedl, 2003, Tumour-cell invasion and migration: diversity and escape mechanisms, Nat. Rev. Cancer, 3, 362, 10.1038/nrc1075

Giannelli, 2002, Clinical role of MMP‐2/TIMP‐2 imbalance in hepatocellular carcinoma, Int. J. Cancer, 97, 425, 10.1002/ijc.1635

Guo, 2010, Anticancer activity and molecular mechanism of resveratrol-bovine serum albumin nanoparticles on subcutaneously implanted human primary ovarian carcinoma cells in nude mice, Cancer Biother. Radiopharm., 25, 471, 10.1089/cbr.2009.0724

Han, 2006, Fibronectin stimulates non–small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways, Cancer Res., 66, 315, 10.1158/0008-5472.CAN-05-2367

Hazlehurst, 2000, Adhesion to fibronectin via β1 integrins regulates p27 kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR), Oncogene, 19, 4319, 10.1038/sj.onc.1203782

Higgins, 1993, Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression, Proc. Natl. Acad. Sci., 90, 9901, 10.1073/pnas.90.21.9901

Hong, 2009, Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells, J. Exp. Clin. Cancer Res., 28, 28, 10.1186/1756-9966-28-28

Hong, 2011, Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness, Cancer Res., 71, 3980, 10.1158/0008-5472.CAN-10-2914

Hsia, 2003, Differential regulation of cell motility and invasion by FAK, J. Cell Biol., 160, 753, 10.1083/jcb.200212114

Hu, 2004, Association of Vimentin overexpression and hepatocellular carcinoma metastasis, Oncogene, 23, 298, 10.1038/sj.onc.1206483

Huber, 2005, Molecular requirements for epithelial–mesenchymal transition during tumor progression, Curr. Opin. Cell Biol., 17, 548, 10.1016/j.ceb.2005.08.001

Hur, 1999

Ince, 1999, The increasing incidence of hepatocellular carcinoma, N. Engl. J. Med., 340, 798, 10.1056/NEJM199903113401009

Jayatilake, 1993, Kinase inhibitors from Polygonum cuspidatum, J. Nat. Prod., 56, 1805, 10.1021/np50100a021

Jia, 2011, Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal‐regulated kinase/matrix metalloproteinase‐9 axis, Hepatology, 54, 1808, 10.1002/hep.24562

Jin, 2007, Chemical constituents in root and rhizome of Polygonum cuspidatum, Chin. Tradit. Herb. Drugs, 38

Ju, 2018, Anticancer effects of methanol extract of Myrmecodia platytyrea Becc. leaves against human hepatocellular carcinoma cells via inhibition of ERK and STAT3 signaling pathways, Int. J. Oncol., 52, 201

Kang, 2004, Epithelial-mesenchymal transitions: twist in development and metastasis, Cell, 118, 277, 10.1016/j.cell.2004.07.011

Kaufhold, 2014, Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention, J. Exp. Clin. Cancer Res., 33, 62, 10.1186/s13046-014-0062-0

Kim, 2008, Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection, J. Microbiol., 46, 737, 10.1007/s12275-008-0232-x

Kim, 2011, Opposite regulation of epithelial-to-mesenchymal transition and cell invasiveness by periostin between prostate and bladder cancer cells, Int. J. Oncol., 38, 1759

Kim, 2018, Emodin sensitizes hepatocellular carcinoma cells to the anti-cancer effect of sorafenib through suppression of cholesterol metabolism, Int. J. Mol. Sci., 19, 10.3390/ijms19103127

Kimura, 2001, Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice, J. Nutr., 131, 1844, 10.1093/jn/131.6.1844

Kimura, 1983, New constituents of roots of Polygonum cuspidatum, J. Planta Med., 48, 164, 10.1055/s-2007-969914

Kleiner, 1999, Matrix metalloproteinases and metastasis, Cancer Chemother. Pharmacol., 43, S42, 10.1007/s002800051097

Krueger, 2001, Temporal and quantitative regulation of mitogen-activated protein kinase (MAPK) modulates cell motility and invasion, Oncogene, 20, 4209, 10.1038/sj.onc.1204541

Kurrey, 2009, Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells, Stem Cells, 27, 2059, 10.1002/stem.154

Lai, 2010, Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway, J. Agric. Food Chem., 58, 2935, 10.1021/jf9036694

Lamouille, 2014, Molecular mechanisms of epithelial-mesenchymal transition, Nat. Rev. Mol. Cell Biol., 15, 178, 10.1038/nrm3758

Le, 2017, Inhibition of protein tyrosine phosphatase non-receptor type 2 by PTP inhibitor XIX: its role as a multiphosphatase inhibitor, BMB Rep., 50, 329, 10.5483/BMBRep.2017.50.6.003

Le, 2018, Methanol extract of Guettarda speciosa Linn. inhibits the production of inflammatory mediators through the inactivation of Syk and JNK in macrophages, Int. J. Mol. Med., 41, 1783

Leu, 2008, Anthraquinones from Polygonum cuspidatum as tyrosinase inhibitors for dermal use, Phytother Res., 22, 552, 10.1002/ptr.2324

Li, 2003

Li, 2009, Twist1-mediated adriamycin-induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells, Clin. Cancer Res., 15, 2657, 10.1158/1078-0432.CCR-08-2372

Li, 2013, Polyflavanostilbene A, a new flavanol-fused stilbene glycoside from Polygonum cuspidatum, Org. Lett., 15, 674, 10.1021/ol3035033

Lin, 2010, Anti-HIV activities of the compounds isolated from Polygonum cuspidatum and Polygonum multiflorum, Planta Med., 76, 889, 10.1055/s-0029-1240796

Lin, 2010, Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts, J. Nat. Med., 64, 146, 10.1007/s11418-009-0387-8

Lin, 2015, Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells, J. Oral Pathol. Med., 44, 699, 10.1111/jop.12288

Lin, 2016, Emodin inhibits migration and invasion of MHCC-97H human hepatocellular carcinoma cells, Exp. Ther. Med., 12, 3369, 10.3892/etm.2016.3793

Lin, 2016, Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo, Oncol. Rep., 36, 961, 10.3892/or.2016.4861

Liu, 2012, Small-molecule STAT3 signaling pathway modulators from Polygonum cuspidatum, Planta Med., 78, 1568, 10.1055/s-0032-1315121

Lu, 2012, Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D 2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells, Food Chem. Toxicol., 50, 913, 10.1016/j.fct.2011.11.046

Matsumoto, 1999, Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration, J. Biol. Chem., 274, 13954, 10.1074/jbc.274.20.13954

McCubrey, 2014, GSK-3 as potential target for therapeutic intervention in cancer, Oncotarget, 5, 2881, 10.18632/oncotarget.2037

McGlynn, 2011, The global epidemiology of hepatocellular carcinoma: present and future, Clin. Liver Dis., 15, 223, 10.1016/j.cld.2011.03.006

Mehta, 2012, Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy, J. Control. Release, 164, 192, 10.1016/j.jconrel.2012.04.045

Minchinton, 2006, Drug penetration in solid tumours, Nat. Rev. Cancer, 6, 583, 10.1038/nrc1893

Moore, 2013, Dual regulation of glycogen synthase kinase 3 (GSK3)alpha/beta by protein kinase C (PKC)alpha and Akt promotes thrombin-mediated integrin alphaIIbbeta3 activation and granule secretion in platelets, J. Biol. Chem., 288, 3918, 10.1074/jbc.M112.429936

Murphy, 2001, Chemokines and the molecular basis of cancer metastasis, N. Engl. J. Med., 345, 833, 10.1056/NEJM200109133451113

Pharmacopoeia, 2000

Qin, 2012, Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms, Cell Res., 22, 90, 10.1038/cr.2011.144

Qin, 2016, Apigenin inhibits NF-κB and snail signaling, EMT and metastasis in human hepatocellular carcinoma, Oncotarget, 7, 41421, 10.18632/oncotarget.9404

Ramaswamy, 2003, A molecular signature of metastasis in primary solid tumors, Nat. Genet., 33, 49, 10.1038/ng1060

Reddy, 2003, Role of MAP kinase in tumor progression and invasion, Cancer Metastasis Rev., 22, 395, 10.1023/A:1023781114568

Sansone, 2012, Targeting the interleukin-6/Jak/stat pathway in human malignancies, J. Clin. Oncol., 30, 1005, 10.1200/JCO.2010.31.8907

Shan, 2008, Antibacterial properties of Polygonum cuspidatum roots and their major bioactive constituents, Food Chem., 109, 530, 10.1016/j.foodchem.2007.12.064

Shin, 2005, H-Ras-specific activation of rac-MKK3/6-p38 pathway its critical role IN invasion and migration OF breast epithelial cells, J. Biol. Chem., 280, 14675, 10.1074/jbc.M411625200

Sivaraman, 1997, Hyperexpression of mitogen-activated protein kinase in human breast cancer, J. Clin. Investig., 99, 1478, 10.1172/JCI119309

Sosic, 2003, Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappa B activity, Cell, 112, 169, 10.1016/S0092-8674(03)00002-3

Steeg, 2008, Metastasis: a therapeutic target for cancer, Nat. Clin. Pract. Oncol., 5, 206, 10.1038/ncponc1066

T'ao, 1986

Takeichi, 1990, Cadherins: a molecular family important in selective cell-cell adhesion, Annu. Rev. Biochem., 59, 237, 10.1146/annurev.bi.59.070190.001321

Thornton, 2008, Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation, Science, 320, 667, 10.1126/science.1156037

Trédan, 2007, Drug resistance and the solid tumor microenvironment, J. Natl. Cancer Inst., 99, 1441, 10.1093/jnci/djm135

Tseng, 2004, Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats, Clin. Cancer Res., 10, 2190, 10.1158/1078-0432.CCR-03-0105

van Ginkel, 2007, Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria, Clin. Cancer Res., 13, 5162, 10.1158/1078-0432.CCR-07-0347

van Ginkel, 2008, Resveratrol inhibits uveal melanoma tumor growth via early mitochondrial dysfunction, Investig. Ophthalmol. Vis. Sci., 49, 1299, 10.1167/iovs.07-1233

Vara, 2004, PI3K/Akt signalling pathway and cancer, Cancer Treat Rev., 30, 193, 10.1016/j.ctrv.2003.07.007

Vastano, 2000, Isolation and identification of stilbenes in two varieties of polygonum c uspidatum, J. Agric. Food Chem., 48, 253, 10.1021/jf9909196

Whittaker, 2010, The role of signaling pathways in the development and treatment of hepatocellular carcinoma, Oncogene, 29, 4989, 10.1038/onc.2010.236

Woo, 2004, Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction, Oncogene, 23, 1845, 10.1038/sj.onc.1207307

Xiao, 2000, Stilbene glycoside sulfates from Polygonum cuspidatum, J. Nat. Prod., 63, 1373, 10.1021/np000086+

Xiao, 2002, Constituents from polygonum cuspidatum, Chem. Pharm. Bull. (Tokyo), 50, 605, 10.1248/cpb.50.605

Xing, 2009, Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits, Biomed. Pharmacother., 63, 457, 10.1016/j.biopha.2008.06.035

Xue, 2012, Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-beta signaling axes, Cancer Discov., 2, 248, 10.1158/2159-8290.CD-11-0270

Yang, 2009, Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma, Hepatology, 50, 1464, 10.1002/hep.23221

Ye, 2017, Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K/Akt, MAPK, NF-κB and Nrf2/HO-1 pathways, Sci. Rep., 7, 11895, 10.1038/s41598-017-12252-3

Yeh, 1988, Effects of anthraquinones of polygonum-cuspidatum on Hl-60 cells, Planta Med., 5, 413, 10.1055/s-2006-962484

Yeh, 2010, Evaluation of serum matrix metalloproteinase (MMP)-9 to MMP-2 ratio as a biomarker in hepatocellular carcinoma, Hepato-Gastroenterology, 57, 98

Yi, 2007, Analysis of rhizoma polygoni cuspidati by HPLC and HPLC-ESI/MS, Phytochem. Anal., 18, 387, 10.1002/pca.993

Yin, 2016, Prp19 facilitates invasion of hepatocellular carcinoma via p38 mitogen-activated protein kinase/twist1 pathway, Oncotarget, 7, 21939, 10.18632/oncotarget.7877

Zhan, 2013, JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1, BMC Canc., 13, 180, 10.1186/1471-2407-13-180

Zhang, 2012, Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice, PLoS One, 7, 10.1371/journal.pone.0046574

Zhang, 2012, Two new anthraquinone malonylglucosides from Polygonum cuspidatum, Nat. Prod. Res., 26, 1323, 10.1080/14786419.2011.578072

Zhou, 1989, Inhibitive effect of water extracts of Polygonum cuspidatum on Ehrlich's carcinoma, Chin. J. Integrated Tradit. West Med., 9, 111

Zhou, 2004, Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition, Nat. Cell Biol., 6, 931, 10.1038/ncb1173

Zhou, 2015, CXCR2/CXCL5 axis contributes to epithelial–mesenchymal transition of HCC cells through activating PI3K/Akt/GSK-3β/Snail signaling, Cancer Lett., 358, 124, 10.1016/j.canlet.2014.11.044

Zhu, 2012, Short hairpin RNA targeting Twist1 suppresses cell proliferation and improves chemosensitivity to cisplatin in HeLa human cervical cancer cells, Oncol. Rep., 27, 1027, 10.3892/or.2012.1633

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Journal of Ethnopharmacology

Tập 245

112179

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