Role of MAP kinase in tumor progression and invasion

Cancer and Metastasis Reviews - Tập 22 - Trang 395-403 - 2003
Kaladhar B. Reddy1, Sanaa M. Nabha1, Natasha Atanaskova1
1Department of Pathology, Wayne State University School of Medicine, Detroit, USA

Tóm tắt

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

Tài liệu tham khảo

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