Hepatic Immune Regulation and Its Involvement in Viral Hepatitis Infection
Tài liệu tham khảo
Thimme, 2003, CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection, J Virol, 77, 68, 10.1128/JVI.77.1.68-76.2003
Breiner, 2001, Endothelial cell-mediated uptake of a hepatitis B virus: a new concept of liver targeting of hepatotropic microorganisms, Hepatology, 34, 803, 10.1053/jhep.2001.27810
Pohlmann, 2003, Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR, J Virol, 77, 4070, 10.1128/JVI.77.7.4070-4080.2003
Thomson, 2010, Antigen-presenting cell function in the tolerogenic liver environment, Nat Rev Immunol, 10, 753, 10.1038/nri2858
Rehermann, 2013, Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells, Nat Med, 19, 859, 10.1038/nm.3251
Crispe, 2009, The liver as a lymphoid organ, Annu Rev Immunol, 27, 147, 10.1146/annurev.immunol.021908.132629
Bissell, 1995, Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation, J Clin Invest, 96, 447, 10.1172/JCI118055
Ito, 2010, Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model, J Immunol, 185, 4554, 10.4049/jimmunol.0904173
Das, 2008, Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection, J Exp Med, 205, 2111, 10.1084/jem.20072076
Jomantaite, 2004, Hepatic dendritic cell subsets in the mouse, Eur J Immunol, 34, 355, 10.1002/eji.200324336
Pillarisetty, 2004, Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition, J Immunol, 172, 1009, 10.4049/jimmunol.172.2.1009
Losikoff, 2012, Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C, Virulence, 3, 610, 10.4161/viru.21823
Velazquez, 2012, Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection, Hepatology, 56, 2071, 10.1002/hep.25904
Benseler, 2007, The liver: a special case in transplantation tolerance, Semin Liver Dis, 27, 194, 10.1055/s-2007-979471
Bowen, 2004, The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity, J Clin Invest, 114, 701, 10.1172/JCI200421593
Holz, 2008, Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death, Gastroenterology, 135, 989, 10.1053/j.gastro.2008.05.078
Benseler, 2011, Hepatocyte entry leads to degradation of autoreactive CD8 T cells, Proc Natl Acad Sci U S A, 108, 16735, 10.1073/pnas.1112251108
Wahl, 2008, B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses, Gastroenterology, 135, 980, 10.1053/j.gastro.2008.05.076
Park, 2012, IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection, Hepatology, 56, 2060, 10.1002/hep.25897
Thomas, 2012, HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons, Gastroenterology, 142, 978, 10.1053/j.gastro.2011.12.055
Schwabe, 2006, Toll-like receptor signaling in the liver, Gastroenterology, 130, 1886, 10.1053/j.gastro.2006.01.038
Schildberg, 2011, Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism, Hepatology, 54, 262, 10.1002/hep.24352
Ichikawa, 2011, Hepatic stellate cells function as regulatory bystanders, J Immunol, 186, 5549, 10.4049/jimmunol.1003917
Seki, 2007, TLR4 enhances TGF-beta signaling and hepatic fibrosis, Nat Med, 13, 1324, 10.1038/nm1663
Schulz, 2012, A lineage of myeloid cells independent of Myb and hematopoietic stem cells, Science, 336, 86, 10.1126/science.1219179
Kinoshita, 2010, Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice, J Hepatol, 53, 903, 10.1016/j.jhep.2010.04.037
Duffield, 2005, Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair, J Clin Invest, 115, 56, 10.1172/JCI200522675
Klein, 2007, Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages, Blood, 110, 4077, 10.1182/blood-2007-02-073841
Callery, 1989, Kupffer cell blockade inhibits induction of tolerance by the portal venous route, Transplantation, 47, 1092, 10.1097/00007890-198906000-00041
Breous, 2009, Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver, Hepatology, 50, 612, 10.1002/hep.23043
You, 2008, Mechanism of T cell tolerance induction by murine hepatic Kupffer cells, Hepatology, 48, 978, 10.1002/hep.22395
Beattie, 2010, Dynamic imaging of experimental Leishmania donovani-induced hepatic granulomas detects Kupffer cell-restricted antigen presentation to antigen-specific CD8 T cells, PLoS Pathog, 6, e1000805, 10.1371/journal.ppat.1000805
Shi, 2010, Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression, J Immunol, 184, 6266, 10.4049/jimmunol.0904160
Huang, 2013, Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection, Nat Immunol, 14, 574, 10.1038/ni.2573
Sorensen, 2012, The scavenger endothelial cell: a new player in homeostasis and immunity, Am J Physiol Regul Integr Comp Physiol, 303, R1217, 10.1152/ajpregu.00686.2011
Kruse, 2009, Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune hepatitis, Hepatology, 50, 1904, 10.1002/hep.23191
Schurich, 2009, Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells, Hepatology, 50, 909, 10.1002/hep.23075
von Oppen, 2009, Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization, Hepatology, 49, 1664, 10.1002/hep.22795
Limmer, 2000, Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance, Nat Med, 6, 1348, 10.1038/82161
Bottcher, 2013, Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity, Cell Rep, 3, 779, 10.1016/j.celrep.2013.02.008
Cooper, 1999, Analysis of a successful immune response against hepatitis C virus, Immunity, 10, 439, 10.1016/S1074-7613(00)80044-8
Maini, 1999, Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection, Gastroenterology, 117, 1386, 10.1016/S0016-5085(99)70289-1
Guidotti, 1996, Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes, Immunity, 4, 25, 10.1016/S1074-7613(00)80295-2
Guidotti, 1999, Viral clearance without destruction of infected cells during acute HBV infection, Science, 284, 825, 10.1126/science.284.5415.825
Jo, 2009, Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model, Gastroenterology, 136, 1391, 10.1053/j.gastro.2008.12.034
Wohlleber, 2012, TNF-induced target cell killing by CTL activated through cross-presentation, Cell Rep, 2, 478, 10.1016/j.celrep.2012.08.001
Cox, 2013, Hepatitis C virus vaccines among people who inject drugs, Clin Infect Dis, 57, S46, 10.1093/cid/cit329
Lauer, 2013, Immune responses to hepatitis C virus (HCV) infection and the prospects for an effective HCV vaccine or immunotherapies, J Infect Dis, 207, S7, 10.1093/infdis/jis762
Chang, 1997, Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. Taiwan Childhood Hepatoma Study Group, N Engl J Med, 336, 1855, 10.1056/NEJM199706263362602
Fafi-Kremer, 2012, Neutralizing antibodies and pathogenesis of hepatitis C virus infection, Viruses, 4, 2016, 10.3390/v4102016
Klenerman, 2012, T cell responses in hepatitis C: the good, the bad and the unconventional, Gut, 61, 1226, 10.1136/gutjnl-2011-300620
Thimme, 2012, Failure of innate and adaptive immune responses in controlling hepatitis C virus infection, FEMS Microbiol Rev, 36, 663, 10.1111/j.1574-6976.2011.00319.x
Lopes, 2008, Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection, J Clin Invest, 118, 1835, 10.1172/JCI33402
Boni, 2007, Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection, J Virol, 81, 4215, 10.1128/JVI.02844-06
Spangenberg, 2005, Intrahepatic CD8+ T-cell failure during chronic hepatitis C virus infection, Hepatology, 42, 828, 10.1002/hep.20856
Wedemeyer, 2002, Impaired effector function of hepatitis C virus-specific CD8+ T cells in chronic hepatitis C virus infection, J Immunol, 169, 3447, 10.4049/jimmunol.169.6.3447
Schlaphoff, 2011, Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells, PLoS Pathog, 7, e1002045, 10.1371/journal.ppat.1002045
Bengsch, 2010, Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation, PLoS Pathog, 6, e1000947, 10.1371/journal.ppat.1000947
Fisicaro, 2010, Antiviral intrahepatic T-cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B, Gastroenterology, 138, 682, 10.1053/j.gastro.2009.09.052
Golden-Mason, 2007, Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction, J Virol, 81, 9249, 10.1128/JVI.00409-07
Golden-Mason, 2009, Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells, J Virol, 83, 9122, 10.1128/JVI.00639-09
Radziewicz, 2007, Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression, J Virol, 81, 2545, 10.1128/JVI.02021-06
Thimme, 2013, Dissecting the divergent effects of interferon-alpha on immune cells: time to rethink combination therapy in chronic hepatitis B?, J Hepatol, 58, 205, 10.1016/j.jhep.2012.11.007
Maini, 2000, The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection, J Exp Med, 191, 1269, 10.1084/jem.191.8.1269
Kakimi, 2001, Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes, J Exp Med, 194, 1755, 10.1084/jem.194.12.1755
Sitia, 2004, MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs, J Clin Invest, 113, 1158, 10.1172/JCI200421087
Sitia, 2002, Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes, Proc Natl Acad Sci U S A, 99, 13717, 10.1073/pnas.172521999
Northfield, 2008, CD161 expression on hepatitis C virus-specific CD8+ T cells suggests a distinct pathway of T cell differentiation, Hepatology, 47, 396, 10.1002/hep.22040
Billerbeck, 2010, Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties, Proc Natl Acad Sci U S A, 107, 3006, 10.1073/pnas.0914839107
Kakimi, 2000, Natural killer T cell activation inhibits hepatitis B virus replication in vivo, J Exp Med, 192, 921, 10.1084/jem.192.7.921
Baron, 2002, Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection, Immunity, 16, 583, 10.1016/S1074-7613(02)00305-9
Zeissig, 2012, Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity, Nat Med, 18, 1060, 10.1038/nm.2811
Jiang, 2011, Restored circulating invariant NKT cells are associated with viral control in patients with chronic hepatitis B, PLoS One, 6, e28871, 10.1371/journal.pone.0028871
Lucas, 2003, Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection, J Virol, 77, 2251, 10.1128/JVI.77.3.2251-2257.2003
Valiante, 2000, Life, activation and death of intra-hepatic lymphocytes in chronic viral hepatitis, Immunol Rev, 174, 77, 10.1034/j.1600-0528.2002.017417.x
Deignan, 2002, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection, J Hepatol, 37, 101, 10.1016/S0168-8278(02)00072-7
Diepolder, 1995, Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection, Lancet, 346, 1006, 10.1016/S0140-6736(95)91691-1
Missale, 1996, Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response, J Clin Invest, 98, 706, 10.1172/JCI118842
Schulze Zur Wiesch, 2012, Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence, J Exp Med, 209, 61, 10.1084/jem.20100388
Asabe, 2009, The size of the viral inoculum contributes to the outcome of hepatitis B virus infection, J Virol, 83, 9652, 10.1128/JVI.00867-09
Raziorrouh, 2011, Inhibitory molecules that regulate expansion and restoration of HCV-specific CD4+ T cells in patients with chronic infection, Gastroenterology, 141, 1422, 10.1053/j.gastro.2011.07.004
Fuller, 2010, Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection, Hepatology, 51, 378, 10.1002/hep.23319
Mueller, 2010, Virus-specific CD4+ T cell responses in chronic HCV infection in blood and liver identified by antigen-specific upregulation of CD154, J Hepatol, 52, 800, 10.1016/j.jhep.2009.12.038
Boettler, 2005, T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection, J Virol, 79, 7860, 10.1128/JVI.79.12.7860-7867.2005
Cabrera, 2004, An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection, Hepatology, 40, 1062, 10.1002/hep.20454
Rushbrook, 2005, Regulatory T cells suppress in vitro proliferation of virus-specific CD8+ T cells during persistent hepatitis C virus infection, J Virol, 79, 7852, 10.1128/JVI.79.12.7852-7859.2005
Sugimoto, 2005, Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection, J Virol, 79, 6976, 10.1128/JVI.79.11.6976-6983.2005
Bolacchi, 2006, Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels, Clin Exp Immunol, 144, 188, 10.1111/j.1365-2249.2006.03048.x
Li, 2009, Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection, PLoS Pathog, 5, e1000707, 10.1371/journal.ppat.1000707
Ebinuma, 2008, Identification and in vitro expansion of functional antigen-specific CD25+ FoxP3+ regulatory T cells in hepatitis C virus infection, J Virol, 82, 5043, 10.1128/JVI.01548-07
Hall, 2010, HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta, PLoS One, 5, e12154, 10.1371/journal.pone.0012154
Ward, 2007, Quantification and localisation of FOXP3+ T lymphocytes and relation to hepatic inflammation during chronic HCV infection, J Hepatol, 47, 316, 10.1016/j.jhep.2007.03.023
Riezu-Boj, 2011, Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection, J Hepatol, 54, 422, 10.1016/j.jhep.2010.07.014
Abel, 2006, Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection, Hepatology, 44, 1607, 10.1002/hep.21438
Accapezzato, 2004, Hepatic expansion of a virus-specific regulatory CD8(+) T cell population in chronic hepatitis C virus infection, J Clin Invest, 113, 963, 10.1172/JCI200420515
Billerbeck, 2007, Parallel expansion of human virus-specific FoxP3- effector memory and de novo-generated FoxP3+ regulatory CD8+ T cells upon antigen recognition in vitro, J Immunol, 179, 1039, 10.4049/jimmunol.179.2.1039
Itose, 2009, Enhanced ability of regulatory T cells in chronic hepatitis C patients with persistently normal alanine aminotransferase levels than those with active hepatitis, J Viral Hepat, 16, 844, 10.1111/j.1365-2893.2009.01131.x
Claassen, 2010, Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis, J Hepatol, 52, 315, 10.1016/j.jhep.2009.12.013
Sturm, 2010, Characterization and role of intra-hepatic regulatory T cells in chronic hepatitis C pathogenesis, J Hepatol, 53, 25, 10.1016/j.jhep.2010.02.024
Werner, 2013, Innate immune responses in hepatitis C virus exposed healthcare workers who do not develop acute infection, Hepatology, 58, 1621, 10.1002/hep.26353
Dunn, 2009, Temporal analysis of early immune responses in patients with acute hepatitis B virus infection, Gastroenterology, 137, 1289, 10.1053/j.gastro.2009.06.054
Varchetta, 2012, Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection, Hepatology, 56, 841, 10.1002/hep.25723
Nattermann, 2006, Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C, Gut, 55, 869, 10.1136/gut.2005.076463
Ahlenstiel, 2010, Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner, Gastroenterology, 138, 325, 10.1053/j.gastro.2009.08.066
Maini, 2013, NK cells: a double-edged sword in chronic hepatitis B virus infection, Front Immunol, 4, 57, 10.3389/fimmu.2013.00057
Mondelli, 2010, Natural killer cells in viral hepatitis: facts and controversies, Eur J Clin Invest, 40, 851, 10.1111/j.1365-2362.2010.02332.x
Oliviero, 2009, Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections, Gastroenterology, 137, 1151, 10.1053/j.gastro.2009.05.047
Peppa, 2010, Blockade of immunosuppressive cytokines restores NK cell antiviral function in chronic hepatitis B virus infection, PLoS Pathog, 6, e1001227, 10.1371/journal.ppat.1001227
Dunn, 2007, Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage, J Exp Med, 204, 667, 10.1084/jem.20061287
Lang, 2012, Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity, Proc Natl Acad Sci U S A, 109, 1210, 10.1073/pnas.1118834109
Waggoner, 2012, Natural killer cells act as rheostats modulating antiviral T cells, Nature, 481, 394, 10.1038/nature10624
Peppa, 2013, Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion, J Exp Med, 210, 99, 10.1084/jem.20121172