Oscillating CD8+ T Cell Effector Functions after Antigen Recognition in the Liver

Ando, 1993, Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis, J. Exp. Med., 178, 1541, 10.1084/jem.178.5.1541 Barry, 2002, Cytotoxic T lymphocytes: all roads lead to death, Nat. Rev. Immunol., 2, 401, 10.1038/nri819 Berke, 1995, The CTL’s kiss of death, Cell, 81, 9, 10.1016/0092-8674(95)90365-8 Castellanos, 1997, Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1, J. Immunol., 159, 5463, 10.4049/jimmunol.159.11.5463 Chisari, 2000, Rous-Whipple Award Lecture. Viruses, immunity, and cancer: lessons from hepatitis B, Am. J. Pathol., 156, 1117, 10.1016/S0002-9440(10)64980-2 D’Souza, 2003, IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion, J. Immunol., 171, 5727, 10.4049/jimmunol.171.11.5727 D’Souza, 2002, Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses, J. Immunol., 168, 5566, 10.4049/jimmunol.168.11.5566 Depper, 1985, Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene, Proc. Natl. Acad. Sci. USA, 82, 4230, 10.1073/pnas.82.12.4230 Dong, 2002, Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion, Nat. Med., 8, 793, 10.1038/nm730 Flynn, 1998, Virus-specific CD8+ T cells in primary and secondary influenza pneumonia, Immunity, 8, 683, 10.1016/S1074-7613(00)80573-7 Freeman, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J. Exp. Med., 192, 1027, 10.1084/jem.192.7.1027 Fuller, 2004, Maintenance, loss, and resurgence of T cell responses during acute, protracted, and chronic viral infections, J. Immunol., 172, 4204, 10.4049/jimmunol.172.7.4204 Guidotti, 1995, High-level hepatitis B virus replication in transgenic mice, J. Virol., 69, 6158, 10.1128/jvi.69.10.6158-6169.1995 Guidotti, 1996, Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes, Immunity, 4, 25, 10.1016/S1074-7613(00)80295-2 Guidotti, 1999, Viral clearance without destruction of infected cells during acute HBV infection, Science, 284, 825, 10.1126/science.284.5415.825 Harty, 2000, CD8+ T cell effector mechanisms in resistance to infection, Annu. Rev. Immunol., 18, 275, 10.1146/annurev.immunol.18.1.275 Ishikawa, 1998, Polyclonality and multispecificity of the CTL response to a single viral epitope, J. Immunol., 161, 5842, 10.4049/jimmunol.161.11.5842 Iwai, 2002, Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade, Proc. Natl. Acad. Sci. USA, 99, 12293, 10.1073/pnas.192461099 Judge, 2002, Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells, J. Exp. Med., 196, 935, 10.1084/jem.20020772 Kakimi, 2000, Natural killer T cell activation inhibits hepatitis B virus replication in vivo, J. Exp. Med., 192, 921, 10.1084/jem.192.7.921 Kakimi, 2002, Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections, J. Virol., 76, 8609, 10.1128/JVI.76.17.8609-8620.2002 Kim, 2002, The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements, EMBO J., 21, 3051, 10.1093/emboj/cdf321 Kuhrober, 1997, DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb- and Kd-restricted epitopes, Int. Immunol., 9, 1203, 10.1093/intimm/9.8.1203 Lalvani, 1997, Rapid effector function in CD8+ memory T cells, J. Exp. Med., 186, 859, 10.1084/jem.186.6.859 Latchman, 2001, PD-L2 is a second ligand for PD-1 and inhibits T cell activation, Nat. Immunol., 2, 261, 10.1038/85330 Lechner, 2000, Analysis of successful immune responses in persons infected with hepatitis C virus, J. Exp. Med., 191, 1499, 10.1084/jem.191.9.1499 Leonard, 1982, A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor, Nature, 300, 267, 10.1038/300267a0 Masopust, 2001, Preferential localization of effector memory cells in nonlymphoid tissue, Science, 291, 2413, 10.1126/science.1058867 McClary, 2000, Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines, J. Virol., 74, 2255, 10.1128/JVI.74.5.2255-2264.2000 Moriyama, 1990, Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice, Science, 248, 361, 10.1126/science.1691527 Murali-Krishna, 1998, Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection, Immunity, 8, 177, 10.1016/S1074-7613(00)80470-7 Okazaki, 2003, Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice, Nat. Med., 9, 1477, 10.1038/nm955 Pien, 2002, A unique mechanism for innate cytokine promotion of T cell responses to viral infections, J. Immunol., 169, 5827, 10.4049/jimmunol.169.10.5827 Sallusto, 1999, Two subsets of memory T lymphocytes with distinct homing potentials and effector functions, Nature, 401, 708, 10.1038/44385 Schirmbeck, 2003, Different immunogenicity of H-2 Kb-restricted epitopes in natural variants of the hepatitis B surface antigen, Eur. J. Immunol., 33, 2429, 10.1002/eji.200324125 Sette, 2001, Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice, J. Immunol., 166, 1389, 10.4049/jimmunol.166.2.1389 Slifka, 2000, Antigen-specific regulation of T cell-mediated cytokine production, Immunity, 12, 451, 10.1016/S1074-7613(00)80197-1 Slifka, 1999, Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells, Nature, 401, 76, 10.1038/43454 Testi, 1989, T cell activation via Leu-23 (CD69), J. Immunol., 143, 1123, 10.4049/jimmunol.143.4.1123 Thimme, 2001, Determinants of viral clearance and persistence during acute hepatitis C virus infection, J. Exp. Med., 194, 1395, 10.1084/jem.194.10.1395 Thimme, 2003, CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection, J. Virol., 77, 68, 10.1128/JVI.77.1.68-76.2003 Wherry, 2003, Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment, J. Virol., 77, 4911, 10.1128/JVI.77.8.4911-4927.2003 Wherry, 2003, Lineage relationship and protective immunity of memory CD8 T cell subsets, Nat. Immunol., 4, 225, 10.1038/ni889 Wieland, 2004, Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees, Proc. Natl. Acad. Sci. USA, 101, 2129, 10.1073/pnas.0308478100 Wolint, 2004, Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells, J. Exp. Med., 199, 925, 10.1084/jem.20031799 Zhang, 1998, Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15, Immunity, 8, 591, 10.1016/S1074-7613(00)80564-6 Zhou, 2004, Differential tissue-specific regulation of antiviral CD8+ T-cell immune responses during chronic viral infection, J. Virol., 78, 3578, 10.1128/JVI.78.7.3578-3600.2004