Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

Proceedings of the National Academy of Sciences of the United States of America - Tập 99 Số 24 - Trang 15661-15668 - 2002
Robert Thimme1, Jens Bukh1, Hans Christian Spangenberg1, Stefan Wieland1, Janell Pemberton1, Carola Steiger1, Sugantha Govindarajan1, Robert H. Purcell1, Francis V. Chisari1
1Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037; University Hospital Freiburg, Department of Medicine II, Hugstetterstrasse 55, 79106 Freiburg, Germany Europe; Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Liver Research Laboratory, Rancho Los Amigos Medical Center, Downey, CA 90242

Tóm tắt

To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-α/β; that viral clearance follows the entry and accumulation of HCV-specific IFN-γ-producing T cells in the liver; and that it may not require the destruction of infected cells.

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Proceedings of the National Academy of Sciences of the United States of America

Tập 99 Số 24

15661-15668

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