Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion

Journal of Hepatology - Tập 59 - Trang 528-535 - 2013
Bastian Höchst1, Frank A. Schildberg1, Pia Sauerborn1, Yvonne A. Gäbel1, Heidrun Gevensleben2, Diane Goltz2, Lukas C. Heukamp3, Andreas Türler4, Matthias Ballmaier5, Friederike Gieseke6, Ingo Müller7, Jörg Kalff8, Christian Kurts1, Percy A. Knolle1, Linda Diehl1
1Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Germany
2Institute for Pathology, Universitätsklinikum Bonn, Germany
3Institute for Pathology University of Cologne Germany
4Department of General and Abdominal Surgery, Johanniter-Krankenhaus Bonn, Germany
5Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Germany
6Research Institute Children's Cancer Center, Hamburg, Germany
7 Clinic for Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
8Department of Surgery, University Hospital, Bonn, Germany

Tài liệu tham khảo

Bronte, 2000, Identification of a CD11b(+)/Gr-1(+)/CD31(+) myeloid progenitor capable of activating or suppressing CD8(+) T cells, Blood, 96, 3838, 10.1182/blood.V96.12.3838 Hoechst, 2011, Plasticity of human Th17 cells and iTregs is orchestrated by different subsets of myeloid cells, Blood, 117, 6532, 10.1182/blood-2010-11-317321 Allavena, 2012, Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment, Clin Exp Immunol, 167, 195, 10.1111/j.1365-2249.2011.04515.x Almand, 2001, Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer, J Immunol, 166, 678, 10.4049/jimmunol.166.1.678 Hoechst, 2008, A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells, Gastroenterology, 135, 234, 10.1053/j.gastro.2008.03.020 Zea, 2005, Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion, Cancer Res, 65, 3044, 10.1158/0008-5472.CAN-04-4505 Dolcetti, 2010, Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF, Eur J Immunol, 40, 22, 10.1002/eji.200939903 Kwan, 2007, LPS induces rapid IL-10 release by M-CSF-conditioned tolerogenic dendritic cell precursors, J Leukoc Biol, 82, 133, 10.1189/jlb.0406267 Chou, 2011, Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice, Hepatology, 53, 1007, 10.1002/hep.24162 Ilkovitch, 2009, The liver is a site for tumor-induced myeloid-derived suppressor cell accumulation and immunosuppression, Cancer Res, 69, 5514, 10.1158/0008-5472.CAN-08-4625 Dangi, 2012, Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance, J Immunol, 188, 3667, 10.4049/jimmunol.1102460 Schildberg, 2011, Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism, Hepatology, 54, 262, 10.1002/hep.24352 Marigo, 2010, Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor, Immunity, 32, 790, 10.1016/j.immuni.2010.05.010 Mandruzzato, 2009, IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients, J Immunol, 182, 6562, 10.4049/jimmunol.0803831 Corzo, 2010, HIF-1{alpha} regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment, J Exp Med., 207, 2439, 10.1084/jem.20100587 Zhao, 2012, S100A9 a new marker for monocytic human myeloid derived suppressor cells, Immunology, 10.1111/j.1365-2567.2012.03566.x Movahedi, 2008, Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity, Blood, 111, 4233, 10.1182/blood-2007-07-099226 Marigo, 2008, Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells, Immunol Rev, 222, 162, 10.1111/j.1600-065X.2008.00602.x Kikuchi, 2005, Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6, J Biol Chem, 280, 15398, 10.1074/jbc.M414048200 Kimura, 2008, Critical role of CD44 in hepatotoxin-mediated liver injury, J Hepatol, 48, 952, 10.1016/j.jhep.2008.01.033 Urashima, 2000, Immunohistochemical study of hyaluronate receptor (CD44) in alcoholic liver disease, Alcohol Clin Exp Res, 24, 34S, 10.1111/j.1530-0277.2000.tb00009.x Endo, 2000, Protein expression of CD44 (standard and variant isoforms) in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, p53 expression, and patient survival, J Hepatol, 32, 78, 10.1016/S0168-8278(00)80192-0 Parker, 1995, Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins, Lancet, 345, 583, 10.1016/S0140-6736(95)90491-3 Thomson, 2010, Antigen-presenting cell function in the tolerogenic liver environment, Nat Rev Immunol, 10, 753, 10.1038/nri2858 Protzer, 2012, Living in the liver: hepatic infections, Nat Rev Immunol, 12, 201, 10.1038/nri3169 Ichikawa, 2011, Hepatic stellate cells function as regulatory bystanders, J Immunol, 186, 5549, 10.4049/jimmunol.1003917 Yu, 2004, Inhibition of T-cell responses by hepatic stellate cells via B7–H1-mediated T-cell apoptosis in mice, Hepatology, 40, 1312, 10.1002/hep.20488 Bronte, 2009, Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions, Eur J Immunol, 39, 2670, 10.1002/eji.200939892 Highfill, 2010, Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13, Blood, 116, 5738, 10.1182/blood-2010-06-287839 Tacke, 2012, Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species, Hepatology, 55, 343, 10.1002/hep.24700 Novo, 2009, Hepatic myofibroblasts: a heterogeneous population of multifunctional cells in liver fibrogenesis, Int J Biochem Cell Biol, 41, 2089, 10.1016/j.biocel.2009.03.010 Pylayeva-Gupta, 2012, Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia, Cancer Cell, 21, 836, 10.1016/j.ccr.2012.04.024 Hsieh, 2013, The role of complement component 3 (C3) in differentiation of myeloid-derived suppressor cells, Blood, 121, 1760, 10.1182/blood-2012-06-440214 Safadi, 2002, Hepatic fibrosis-role of hepatic stellate cell activation, MedGenMed, 4, 27 Friedman, 2008, Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver, Physiol Rev, 88, 125, 10.1152/physrev.00013.2007 Lapidot, 2005, How do stem cells find their way home?, Blood, 106, 1901, 10.1182/blood-2005-04-1417 Ohata, 2009, Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells, Biochem Biophys Res Commun, 379, 817, 10.1016/j.bbrc.2008.12.149 Ng, 2008, Two-photon imaging of effector T-cell behavior: lessons from a tumor model, Immunol Rev, 221, 147, 10.1111/j.1600-065X.2008.00596.x Hertweck, 2011, CD44 in hematological neoplasias, Ann Hematol, 90, 493, 10.1007/s00277-011-1161-z Nojima, 1992, Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein, J Exp Med, 175, 1045, 10.1084/jem.175.4.1045 Brown, 2011, CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression, J Clin Invest, 121, 1064, 10.1172/JCI44540 Braet, 2009, Three-dimensional organization of fenestrae labyrinths in liver sinusoidal endothelial cells, Liver Int, 29, 603, 10.1111/j.1478-3231.2008.01836.x Wiegard, 2005, Murine liver antigen presenting cells control suppressor activity of CD4+CD25+ regulatory T cells, Hepatology, 42, 193, 10.1002/hep.20756 Greten, 2011, Myeloid derived suppressor cells in human diseases, Int Immunopharmacol, 11, 802, 10.1016/j.intimp.2011.01.003 Chuaysri, 2009, Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma, Oncol Rep, 21, 957 Nakagawa, 2012, Inflammation- and stress-related signaling pathways in hepatocarcinogenesis, World J Gastroenterol, 18, 4071, 10.3748/wjg.v18.i31.4071