Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

Akira, 2011, Innate immunity and adjuvants, Philos. Trans. R. Soc. Lond. B Biol. Sci., 366, 2748, 10.1098/rstb.2011.0106 Andonegui, 2005, Platelets express functional Toll-like receptor-4, Blood, 106, 2417, 10.1182/blood-2005-03-0916 Borregaard, 2010, Neutrophils, from marrow to microbes, Immunity, 33, 657, 10.1016/j.immuni.2010.11.011 Breitbach, 2011, Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans, Nature, 477, 99, 10.1038/nature10358 Brinkmann, 2004, Neutrophil extracellular traps kill bacteria, Science, 303, 1532, 10.1126/science.1092385 Carvalho-Tavares, 2000, A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature, Circ. Res., 87, 1141, 10.1161/01.RES.87.12.1141 Christensen, 2009, Co-ordinating innate and adaptive immunity to viral infection: mobility is the key, APMIS, 117, 338, 10.1111/j.1600-0463.2009.02451.x Clark, 2007, Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood, Nat. Med., 13, 463, 10.1038/nm1565 de la Motte, 2003, Mononuclear leukocytes bind to specific hyaluronan structures on colon mucosal smooth muscle cells treated with polyinosinic acid:polycytidylic acid: inter-alpha-trypsin inhibitor is crucial to structure and function, Am. J. Pathol., 163, 121, 10.1016/S0002-9440(10)63636-X Doss, 2009, Interactions of alpha-, beta-, and theta-defensins with influenza A virus and surfactant protein D, J. Immunol., 182, 7878, 10.4049/jimmunol.0804049 France, 2011, Intraventricular injection of myxoma virus results in transient expression of viral protein in mouse brain ependymal and subventricular cells, J. Gen. Virol., 92, 195, 10.1099/vir.0.026690-0 Gitlin, 2006, Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus, Proc. Natl. Acad. Sci. USA, 103, 8459, 10.1073/pnas.0603082103 Hament, 1999, Respiratory viral infection predisposing for bacterial disease: a concise review, FEMS Immunol. Med. Microbiol., 26, 189, 10.1111/j.1574-695X.1999.tb01389.x Hemmers, 2011, PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection, PLoS ONE, 6, e22043, 10.1371/journal.pone.0022043 Hussell, 2004, Ménage à trois of bacterial and viral pulmonary pathogens delivers coup de grace to the lung, Clin. Exp. Immunol., 137, 8, 10.1111/j.1365-2249.2004.02526.x Jenne, 2011, The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation, PLoS ONE, 6, e25109, 10.1371/journal.pone.0025109 Kornerup, 2010, Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration, J. Appl. Physiol., 109, 758, 10.1152/japplphysiol.01086.2009 Kumar, 2009, Critically ill patients with 2009 influenza A(H1N1) infection in Canada, JAMA, 302, 1872, 10.1001/jama.2009.1496 Lee, 2010, An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells, Nat. Immunol., 11, 295, 10.1038/ni.1855 McDonald, 2008, Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids, J. Exp. Med., 205, 915, 10.1084/jem.20071765 McDonald, 2010, Intravascular danger signals guide neutrophils to sites of sterile inflammation, Science, 330, 362, 10.1126/science.1195491 McDonald, 2012, Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis, Cell Host Microbe, 12, 324, 10.1016/j.chom.2012.06.011 McGill, 2009, Innate immune control and regulation of influenza virus infections, J. Leukoc. Biol., 86, 803, 10.1189/jlb.0509368 Medina, 2009, Neutrophil extracellular traps: a strategic tactic to defeat pathogens with potential consequences for the host, J. Innate Immun., 1, 176, 10.1159/000203699 Menezes, 2009, Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10, J. Immunol., 183, 7557, 10.4049/jimmunol.0901786 Pak, 2010, Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion, Platelets, 21, 282, 10.3109/09537101003637265 Pang, 2011, Inflammasomes as mediators of immunity against influenza virus, Trends Immunol., 32, 34, 10.1016/j.it.2010.11.004 Perrone, 2008, H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice, PLoS Pathog., 4, e1000115, 10.1371/journal.ppat.1000115 Protzer, 2012, Living in the liver: hepatic infections, Nat. Rev. Immunol., 12, 201, 10.1038/nri3169 Rosenfeld, 1985, Human platelet Fc receptor for immunoglobulin G. Identification as a 40,000-molecular-weight membrane protein shared by monocytes, J. Clin. Invest., 76, 2317, 10.1172/JCI112242 Saitoh, 2012, Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1, Cell Host Microbe, 12, 109, 10.1016/j.chom.2012.05.015 Schoen, 1997, Inhibition of influenza virus fusion by polyanionic proteins, Biochem. Pharmacol., 53, 995, 10.1016/S0006-2952(96)00876-3 Semple, 2010, Platelets and innate immunity, Cell. Mol. Life Sci., 67, 499, 10.1007/s00018-009-0205-1 Stanford, 2007, Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer, Expert Opin. Biol. Ther., 7, 1415, 10.1517/14712598.7.9.1415 Stanford, 2008, Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo, Mol. Ther., 16, 52, 10.1038/sj.mt.6300348 Takeuchi, 2008, MDA5/RIG-I and virus recognition, Curr. Opin. Immunol., 20, 17, 10.1016/j.coi.2008.01.002 Tang, 2009, MAVS self-association mediates antiviral innate immune signaling, J. Virol., 83, 3420, 10.1128/JVI.02623-08 Tate, 2009, Neutrophils ameliorate lung injury and the development of severe disease during influenza infection, J. Immunol., 183, 7441, 10.4049/jimmunol.0902497 Thomas, 2009, The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1, Immunity, 30, 566, 10.1016/j.immuni.2009.02.006 Van Rooijen, 1994, Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications, J. Immunol. Methods, 174, 83, 10.1016/0022-1759(94)90012-4 Vanichakarn, 2008, Neutrophil CD40 enhances platelet-mediated inflammation, Thromb. Res., 122, 346, 10.1016/j.thromres.2007.12.019 Venkata, 2010, Hospitalized patients with 2009 H1N1 influenza infection: the Mayo Clinic experience, Mayo Clin. Proc., 85, 798, 10.4065/mcp.2010.0166 von Hundelshausen, 2009, Platelet-mediated enhancement of leukocyte adhesion, Microcirculation, 16, 84, 10.1080/10739680802564787 Wang, 2004, Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier, Nat. Immunol., 5, 1266, 10.1038/ni1132 Wong, 1997, A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature, J. Clin. Invest., 99, 2782, 10.1172/JCI119468 Yoneyama, 2004, The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Nat. Immunol., 5, 730, 10.1038/ni1087 Zhang, 2007, CD41-YFP mice allow in vivo labeling of megakaryocytic cells and reveal a subset of platelets hyperreactive to thrombin stimulation, Exp. Hematol., 35, 490, 10.1016/j.exphem.2006.11.011 Zhuo, 2006, SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum, J. Biol. Chem., 281, 20303, 10.1074/jbc.M506703200