Wiley
0001-6683
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
A Study on the Fate of Curcumin in the RatAbstract The uptake, distribution and excretion of curcumin in Sprague‐Dawley rats has been studied. When administered orally in a dose of 1 g/kg, curcumin was excreted in the faeces to about 75%, while negligible amounts of curcumin appeared in the urine. Measurements of blood plasma levels and biliary excretion showed that curcumin was poorly absorbed from the gut....
Tập 43 Số 2 - Trang 86-92 - 1978
Distribution of Cadmium Among Protein Fractions of Mouse Liver1)Liver proteins from mice injected subcutaneously with cadmium chloride (3 mg Cd/kg body weight) were separated on G‐75 Sephadex at intervals 20 min.‐21 days after injection. Fairly soon after the injection, cadmium was found bound to proteins of high molecular weight whereas at survival times exceeding 24 hours the cadmium was associated with a low molecular weight protein. In mice repeate... ...
Tập 29 Số 5-6 - Trang 456-470 - 1971
The Direct Demonstration of a Barrier Mechanism in the Brain Capillaries
Tập 20 Số 4 - Trang 317-321 - 1964
Quantitative determination of metoprolol in plasma and urine by gas chromatographyAbstract: A procedure for the gas chromatographic determination of the β‐receptor blocking agent metoprolol at therapeutic levels in plasma and urine is described. Metoprolol is made electron capture sensitive by a derivatization reaction with trifluoroacetic anhydride. The method permits determination of concentrations of metoprolol down to about 5 ng/g of sample w...
Tập 36 Số s5 - Trang 136-144 - 1975
Pharmacological Characterization of the Autonomous Innervation of the Guinea Pig Tracheobronchial Smooth MuscleAbstract: From the trachea, main bronchi and hilus bronchi of guinea pigs, preparations were isolated for registration of mechanical tension on electrical field stimulation and drugs. The trachea contracted on short trains of electrical stimulation. Usually these contractions were followed by a relaxant response. The contractions were abolished while the relaxations...
Tập 49 Số 2 - Trang 150-157 - 1981
A Comparative Study on the Effects of Disulfiram, Cyanamide and 1‐Aminocyclopropanol on the Acetaldehyde Metabolism in RatsAbstract 1‐aminocyclopropanol (ACP) is a potent inhibitor of aldehyde dehydrogenase (ALDH) in vivo and in vitro. Like cyanamide it has a rapid onset of action in vivo with the highest inhibition occurring after 2‐24 hrs. and a long duration of action like disulfiram with measurable inhib...
Tập 43 Số 3 - Trang 219-232 - 1978
The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the RatAbstract: Nociceptive stimulation has been performed in rats with a technique which should allow us to study different pain projection levels within the central nervous system. Three different types of thresholds were studied by electrical stimulation and the stimulus responses were qualitatively and quantitatively divided into a) motor response b) vocalisation and ...
Tập 32 Số 1-2 - Trang 22-32 - 1973
Human Pharmacokinetics of SotalolAbstract The pharmacokinetics of sotalol were studied in healthy volunteers after a single dose and in hypertensive patients after chronic administration. A single 160 mg and two 80 mg socator® tablets were compared and found to be bioequivalent in terms of relative total bioavailability. Sotalol was well absorbed, about 73 % of the dose being excreted in the urine w...
Tập 39 Số 1 - Trang 118-128 - 1976
The Effect of Dopamine and Noradrenaline Antagonists on Amphetamine Induced Locomotor Activity in Mice and RatsAbstract: The effect of noradrenaline antagonists, aceperone, phenoxybenzamine and dihydroergotamine and neuroleptic drugs with dopamine receptor blocking properties, i. e. haloperidol, perphenazine, trifluperazine, spiramide and pimozide was tested on the locomotor and rearing activity induced by amphetamine, 2.5 mg/kg, in rats. In general it was found that the neu...
Tập 33 Số 5-6 - Trang 385-399 - 1973
Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol AdministrationAbstract Rats of the Sprague‐Dawley strain were maintained on ad libitum food and a forced‐intake regimen of ethanol for up to 270 days. Bilateral application of dopamine (DA) into the nucleus accumbens of both chronic ethanol rats and rats undergoing withdrawal produced a pronounced increase in coordinated locomotor activity which was 8–10 times higher than that of ...
Tập 43 Số 1 - Trang 19-28 - 1978