Wiley
0001-6683
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Các bài báo tiêu biểu
A Study on the Fate of Curcumin in the Rat
Tập 43 Số 2 - Trang 86-92 - 1978
Abstract The uptake, distribution and excretion of curcumin in Sprague‐Dawley
rats has been studied. When administered orally in a dose of 1 g/kg, curcumin
was excreted in the faeces to about 75%, while negligible amounts of curcumin
appeared in the urine. Measurements of blood plasma levels and biliary excretion
showed that curcumin was poorly absorbed from the gut. No apparent toxic effects
were...
Distribution of Cadmium Among Protein Fractions of Mouse Liver1)
Tập 29 Số 5-6 - Trang 456-470 - 1971
Liver proteins from mice injected subcutaneously with cadmium chloride (3 mg
Cd/kg body weight) were separated on G‐75 Sephadex at intervals 20 min.‐21 days
after injection. Fairly soon after the injection, cadmium was found bound to
proteins of high molecular weight whereas at survival times exceeding 24 hours
the cadmium was associated with a low molecular weight protein. In mice
repeatedly expo...
The Direct Demonstration of a Barrier Mechanism in the Brain Capillaries
Tập 20 Số 4 - Trang 317-321 - 1964
Quantitative determination of metoprolol in plasma and urine by gas chromatography
Tập 36 Số s5 - Trang 136-144 - 1975
Abstract: A procedure for the gas chromatographic determination of the
β‐receptor blocking agent metoprolol at therapeutic levels in plasma and urine
is described. Metoprolol is made electron capture sensitive by a derivatization
reaction with trifluoroacetic anhydride. The method permits determination of
concentrations of metoprolol down to about 5 ng/g of sample with a standard
deviation of 0.7 ...
Pharmacological Characterization of the Autonomous Innervation of the Guinea Pig Tracheobronchial Smooth Muscle
Tập 49 Số 2 - Trang 150-157 - 1981
Abstract: From the trachea, main bronchi and hilus bronchi of guinea pigs,
preparations were isolated for registration of mechanical tension on electrical
field stimulation and drugs. The trachea contracted on short trains of
electrical stimulation. Usually these contractions were followed by a relaxant
response. The contractions were abolished while the relaxations were potentiated
by atropine. I...
A Comparative Study on the Effects of Disulfiram, Cyanamide and 1‐Aminocyclopropanol on the Acetaldehyde Metabolism in Rats
Tập 43 Số 3 - Trang 219-232 - 1978
Abstract 1‐aminocyclopropanol (ACP) is a potent inhibitor of aldehyde
dehydrogenase (ALDH) in vivo and in vitro. Like cyanamide it has a rapid onset
of action in vivo with the highest inhibition occurring after 2‐24 hrs. and a
long duration of action like disulfiram with measurable inhibition after 144
hrs. All the three inhibitors decreased the activity of the mitochondrial low‐Km
ALDH strongly i...
The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the Rat
Tập 32 Số 1-2 - Trang 22-32 - 1973
Abstract: Nociceptive stimulation has been performed in rats with a technique
which should allow us to study different pain projection levels within the
central nervous system. Three different types of thresholds were studied by
electrical stimulation and the stimulus responses were qualitatively and
quantitatively divided into a) motor response b) vocalisation and c)
vocalisation after‐discharge....
Human Pharmacokinetics of Sotalol
Tập 39 Số 1 - Trang 118-128 - 1976
Abstract The pharmacokinetics of sotalol were studied in healthy volunteers
after a single dose and in hypertensive patients after chronic administration. A
single 160 mg and two 80 mg socator® tablets were compared and found to be
bioequivalent in terms of relative total bioavailability. Sotalol was well
absorbed, about 73 % of the dose being excreted in the urine within 72 hours.
The absolute bi...
The Effect of Dopamine and Noradrenaline Antagonists on Amphetamine Induced Locomotor Activity in Mice and Rats
Tập 33 Số 5-6 - Trang 385-399 - 1973
Abstract: The effect of noradrenaline antagonists, aceperone, phenoxybenzamine
and dihydroergotamine and neuroleptic drugs with dopamine receptor blocking
properties, i. e. haloperidol, perphenazine, trifluperazine, spiramide and
pimozide was tested on the locomotor and rearing activity induced by
amphetamine, 2.5 mg/kg, in rats. In general it was found that the neuroleptic
drugs in very low doses...
Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration
Tập 43 Số 1 - Trang 19-28 - 1978
Abstract Rats of the Sprague‐Dawley strain were maintained on ad libitum food
and a forced‐intake regimen of ethanol for up to 270 days. Bilateral application
of dopamine (DA) into the nucleus accumbens of both chronic ethanol rats and
rats undergoing withdrawal produced a pronounced increase in coordinated
locomotor activity which was 8–10 times higher than that of untreated water
control rats. T...