Quantitative determination of metoprolol in plasma and urine by gas chromatography

Wiley - Tập 36 Số s5 - Trang 136-144 - 1975
Magnar Ervik1
1Department of Analytical Chemistry and Biochemistry, AB Hässle, Fack, S‐431 20 Mölndal, Sweden

Tóm tắt

Abstract: A procedure for the gas chromatographic determination of the β‐receptor blocking agent metoprolol at therapeutic levels in plasma and urine is described. Metoprolol is made electron capture sensitive by a derivatization reaction with trifluoroacetic anhydride. The method permits determination of concentrations of metoprolol down to about 5 ng/g of sample with a standard deviation of 0.7 ng. Automation of the gas chromatographic procedure gives a capacity of 24 samples a day.

Từ khóa


Tài liệu tham khảo

10.1016/S0021-9673(01)91714-5

Ehrsson H., 1971, Diperfluoroacylation of primary amines, Acta pharm. suec., 8, 591

Ervik M., 1969, Gas chromatographic determinations of the secondary amine alprenolol, as its trifluoroacetyl derivative, at nanogram levels in biological fluids, Acta pharm. suec., 6, 393

10.1016/S0021-9673(01)91783-2

Nambara T., 1973, Determination of oxprenolol in human blood plasma by gas chromatography, Yakugaku Zasshi, 93, 439, 10.1248/yakushi1947.93.4_439

Walle T., 1970, Quantitative gas chromatographic determination of picogram quantities of amino and alcoholic compounds by electron capture detection, Acta pharm. suec., 7, 389

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Thông tin xuất bản

Wiley

Tập 36 Số s5

136-144

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