Distribution of Cadmium Among Protein Fractions of Mouse Liver1)

Wiley - Tập 29 Số 5-6 - Trang 456-470 - 1971
Gunnar F. Nordberg1, Magnus Piscator1, Birger Lind1
1From the Institute of Hygiene, Karolinska Institutet and Department of Environmental Health, National Institute of Public Health, Stockholm, Sweden

Tóm tắt

Liver proteins from mice injected subcutaneously with cadmium chloride (3 mg Cd/kg body weight) were separated on G‐75 Sephadex at intervals 20 min.‐21 days after injection. Fairly soon after the injection, cadmium was found bound to proteins of high molecular weight whereas at survival times exceeding 24 hours the cadmium was associated with a low molecular weight protein. In mice repeatedly exposed to cadmium (0.25 mg/kg, daily, 5 days/week) for periods up to 5 months, cadmium was principally bound to the low molecular weight protein, which has characteristics in common with the earlier described protein, metallothionein. The importance of “mouse metallothionein” in the toxicity of cadmium is discussed.

Từ khóa


Tài liệu tham khảo

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Wiley

Tập 29 Số 5-6

456-470

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