The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the Rat

Wiley - Tập 32 Số 1-2 - Trang 22-32 - 1973
Gudrun Paalzow1, Lennart Paalzow1
1Department of Pharmacology, Biomedical Center, Box 573, S‐751 23 Uppsala and Apotekens Centrallaboratorium, Box 3045, S‐171 03 Solna, Sweden

Tóm tắt

Abstract: Nociceptive stimulation has been performed in rats with a technique which should allow us to study different pain projection levels within the central nervous system. Three different types of thresholds were studied by electrical stimulation and the stimulus responses were qualitatively and quantitatively divided into a) motor response b) vocalisation and c) vocalisation after‐discharge. Caffeine and theophylline were able to decrease the thresholds for motor response and vocalisation in a dose‐dependent manner. Both drugs were also able to reduce the thresholds for vocalisation after‐discharge. However, caffeine reduced this response to about 50‐60% of the normal, but not in a dose‐dependent manner, which is contrary to theophylline which, in a dose of 100 mg/kg, decreased the threshold to as little as 20 per cent of the normal. In general, maximum effects were obtained 30 minutes after administration and theophylline produced more long‐lasting effects than caffeine.

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Wiley

Tập 32 Số 1-2

22-32

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