Changes in the Sensitivity of Dopamine Receptors in the Nucleus Accumbens and in the Striatum Induced by Chronic Ethanol Administration

Wiley - Tập 43 Số 1 - Trang 19-28 - 1978
Sture Liljequist1
1From the Department of Pharmacology, University of Göteborg, S‐40033 Göteborg, Sweden

Tóm tắt

Abstract Rats of the Sprague‐Dawley strain were maintained on ad libitum food and a forced‐intake regimen of ethanol for up to 270 days. Bilateral application of dopamine (DA) into the nucleus accumbens of both chronic ethanol rats and rats undergoing withdrawal produced a pronounced increase in coordinated locomotor activity which was 8–10 times higher than that of untreated water control rats. This phenomenon was first observed after 5 months of ethanol treatment and lasted for about 4 weeks after cessation of the treatment. It is concluded that prolonged ethanol administration produces an increased sensitivity of the DA‐receptors in the nucleus accumbens and further supports the contention that central catecholamine mechanisms are involved in the mediation of the withdrawal syndrome observed after chronic treatment with ethanol.

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Tài liệu tham khảo

Ahtee L., 1975, Effect of ethanol dependence and withdrawal on the catecholamines in rat brain and heart, Acta pharmacol. et toxicol., 36, 289, 10.1111/j.1600-0773.1975.tb00796.x

10.1007/BF00422706

10.1111/j.2042-7158.1973.tb09129.x

10.1111/j.2042-7158.1966.tb07817.x

10.1073/pnas.70.8.2411

10.1002/jcp.1030660524

Ehrenpreis S., 1972, Chemical and biological aspects of drug dependence, 177

Engel J., 1977, Current developments in psychopharmacology, 1

10.1007/BF00426825

Fleming W. W., 1976, Variable sensitivity of excitable cells: possible mechanisms and biological significance, Reviews of neuroscience., 2, 43

10.1139/y75-036

10.1111/j.2042-7158.1973.tb10026.x

10.1111/j.1476-5381.1974.tb08582.x

10.1111/j.1471-4159.1974.tb06058.x

10.1007/BF00427289

10.1007/BF00429052

10.1111/j.1476-5381.1976.tb07450.x

Kebabian J. W., 1975, Dopaminergic mechanisms, 1

10.1073/pnas.69.8.2145

König J. F., 1963, The rat brain. A stereotaxic atlas of the forebrain and lower parts of the brain stem

Liljequist S., 1977, The effect of chronic ethanol treatment on behaviour and central monoamines in the rat, Naunyn-Schmiedeberg's Arch Pharmacol., 300, 205, 10.1007/BF00500962

10.1007/978-1-4615-9038-5_16

10.1016/0006-8993(76)90726-5

Pohorecky L. A., 1975, Noradrenergic involvement in the acute effects of ethanol, Res. Comm. Chem. Path. Pharmacol., 12, 433

10.1016/0024-3205(74)90341-5

Post M. E., 1973, The effect of chronic ethanol administration on the levels of catecholamines in different regions of the rat brain, Res. Comm. Chem. Path. Pharmacol., 6, 887

10.1007/BF00404231

10.1126/science.132.3418.42

10.1007/BF00403689

10.1016/0014-2999(76)90208-9

Waldeck B., 1975, Effect of caffeine on locomotor activity and central catecholamine mechanisms: a study with special reference to drug interactions, Acta pharmacol. et toxicol., 36

10.1007/978-1-4757-0632-1_3

Weiss B., 1969, Effects of environmental lighting and chronic denervation on the activation of adenyl cyclase of rat pineal gland by norephinephrine and sodium fluoride, J. Pharmacol. exp. Ther., 168, 146

Weiss B., 1964, Effects of amphetamine, chlorpromazine, pentobarbital, and ethanol on operant response duration, J. Pharmacol. exp. Ther., 144, 17

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Wiley

Tập 43 Số 1

19-28

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