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Blockage of chloride channels and anion transporters with pesticidal natural products and their synthetic analogs
Springer Science and Business Media LLC - Tập 10 - Trang 217-226 - 2010
Ligand-gated chloride channels mediate a variety of functions in excitable membranes of nerve and muscle in insects, and have a long history as targets for neurotoxic insecticides. Recent findings from our laboratory confirm that the natural product silphinenes and their semi-synthetic analogs share a mode of action with the established ligand-gated chloride channel antagonist, picrotoxinin. The s...... hiện toàn bộ
Medicinal plants and phytochemicals against multidrug-resistant tumor cells expressing ABCB1, ABCG2, or ABCB5: a synopsis of 2 decades
Springer Science and Business Media LLC - Tập 20 - Trang 7-53 - 2020
Multidrug resistance is a major factor causing the failure of cancer chemotherapy. Efflux pumps of the ATP-binding cassette (ABC) transporter family expel a large array of diverse anticancer drugs out of tumor cells thereby rendering them unresponsive to drug treatment. During the past 2 decades, we focused on three ABC transporters, i.e. P-glycoprotein (MDR1/ABCB1), breast cancer resistance prote...... hiện toàn bộ
Letter to the editor: “It is not just artemisinin: Artemisia sp. for treating diseases including malaria and schistosomiasis
Springer Science and Business Media LLC - - 2024
An updated review of genus Cistus L. since 2014: traditional uses, phytochemistry, and pharmacological properties
Springer Science and Business Media LLC - Tập 21 - Trang 2049-2087 - 2022
Genus Cistus L. (Cistaceae) occurs mainly in the Mediterranean region. Many plants of this genus have been used in different folk medicines since ancient times, mainly against peptic ailments and skin disorders, such as burns, wounds, and infections. Over the last years, Cistus species have attracted great interest due to the variety of their bioactive compounds and pharmacological activities. Com...... hiện toàn bộ
13C-2H correlation NMR spectroscopy studies of the in vivo transformations of natural products from Artemisia annua
Springer Science and Business Media LLC - Tập 2 - Trang 45-59 - 2003
13C-2H correlation NMR spectroscopy (13C-2H COSY) permits the identification of 13C and 2H nuclei which are connected to one another by a single chemical bond via the sizeable 1JCD coupling constant. The practical development of this technique is described using a 13C-2H COSY pulse sequence which is derived from the classical 13C-1H correlation experiment. An example is given of the application o...... hiện toàn bộ
Interactions between glucosinolate- and myrosinase-containing plants and the sawfly Athalia rosae
Springer Science and Business Media LLC - Tập 8 - Trang 121-134 - 2008
Several insects have specialised on using Brassicaceae as host plants. Therefore, they evolved metabolic pathways to cope with the defensive glucosinolate–myrosinase system of their diet. Larvae of the turnip sawfly, Athalia rosae L. (Hymenoptera: Tenthredinidae), incorporate various glucosinolates from their hosts into their haemolymph. The ability to sequester these metabolites makes A. rosae a ...... hiện toàn bộ
Allelopathy in tropical and subtropical species
Springer Science and Business Media LLC - Tập 17 - Trang 1225-1237 - 2018
The ability of certain plants to synthesize allelochemicals that disrupt the germination, development, reproduction and/or survival of organisms that compete with them for resources has been observed in a variety of environments worldwide. Tropical and subtropical regions are particularly conducive to the evolution of allelopathic survival strategies as the relatively constant temperatures and mil...... hiện toàn bộ
Preparative separation and bioactivity of oligomeric proanthocyanidins
Springer Science and Business Media LLC - Tập 19 Số 5 - Trang 1093-1140 - 2020
From plants to pharmacy shelf: natural products revival
Springer Science and Business Media LLC - Tập 15 Số 4 - Trang 511-513 - 2016
Lichens: a promising source of antibiotic and anticancer drugs
Springer Science and Business Media LLC - Tập 12 - Trang 229-244 - 2013
Lichens are symbiotic associations between fungi and a photosynthetic alga and/or cyanobacteria. Lichenized fungi have been found to produce a wide array of secondary metabolites, most of which are unique to the lichenized condition. These secondary metabolites have shown an impressive range of biological activities including antibiotics, antifungal, anti-HIV, anticancer, anti-protozoan, etc. This...... hiện toàn bộ
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