Nghiên cứu hóa thực vật và hoạt tính sinh học của ba loài Schisandra Trung Quốc (Schisandra sphenanthera, Schisandra henryi và Schisandra rubriflora): những phát hiện hiện tại và ứng dụng trong tương lai

Springer Science and Business Media LLC - Tập 18 - Trang 109-128 - 2018
Agnieszka Szopa1, Magda Barnaś1, Halina Ekiert1
1Chair and Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland

Tóm tắt

Schisandra chinensis (vòng hoa Trung Quốc) là đại diện nổi tiếng nhất của chi Schisandra, thường được sử dụng trong y học chính thức ở Đông Á, Bắc Mỹ và châu Âu. Bài báo nhắc lại giá trị chữa bệnh của loài này và, trên hết, trình bày tình trạng hiện tại về kiến thức hóa học và hoạt tính sinh học của ba loài khác thuộc chi Schisandra: Schisandra sphenanthera, Schisandra henryi và Schisandra rubriflora. Ngoài các lignan dibenzocyclooctadiene (được gọi là ‘lignan Schisandra chinensis’), chúng còn chứa các nhóm lignan khác (ví dụ: 4-aryltetralin, aryltetralone, tetrahydrofuran và lignan loại butane) là các hợp chất chính có trách nhiệm cho hoạt tính sinh học. Các lignan được đi kèm bởi các nhóm hợp chất khác, bao gồm triterpenoid và nortriterpenoid. Một đánh giá về các nghiên cứu sinh học, chẳng hạn như các hoạt động bảo vệ gan, gây độc tế bào và chống HIV-1 đã được xác nhận một cách thực nghiệm, chứng minh rằng những loài này có tiềm năng chữa bệnh cao và có thể tạo thành một đề xuất mới của Đông Á cho y học châu Âu. Bài báo cũng chú ý đến khả năng sử dụng tiềm năng tổng hợp sinh học của sinh khối từ các văn hóa in vitro của các loài được mô tả và các giải pháp công nghệ sinh học như một giải pháp thay thế cho nguyên liệu thực vật.

Từ khóa


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