Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Nghiên cứu hóa thực vật và hoạt tính sinh học của ba loài Schisandra Trung Quốc (Schisandra sphenanthera, Schisandra henryi và Schisandra rubriflora): những phát hiện hiện tại và ứng dụng trong tương lai
Tóm tắt
Schisandra chinensis (vòng hoa Trung Quốc) là đại diện nổi tiếng nhất của chi Schisandra, thường được sử dụng trong y học chính thức ở Đông Á, Bắc Mỹ và châu Âu. Bài báo nhắc lại giá trị chữa bệnh của loài này và, trên hết, trình bày tình trạng hiện tại về kiến thức hóa học và hoạt tính sinh học của ba loài khác thuộc chi Schisandra: Schisandra sphenanthera, Schisandra henryi và Schisandra rubriflora. Ngoài các lignan dibenzocyclooctadiene (được gọi là ‘lignan Schisandra chinensis’), chúng còn chứa các nhóm lignan khác (ví dụ: 4-aryltetralin, aryltetralone, tetrahydrofuran và lignan loại butane) là các hợp chất chính có trách nhiệm cho hoạt tính sinh học. Các lignan được đi kèm bởi các nhóm hợp chất khác, bao gồm triterpenoid và nortriterpenoid. Một đánh giá về các nghiên cứu sinh học, chẳng hạn như các hoạt động bảo vệ gan, gây độc tế bào và chống HIV-1 đã được xác nhận một cách thực nghiệm, chứng minh rằng những loài này có tiềm năng chữa bệnh cao và có thể tạo thành một đề xuất mới của Đông Á cho y học châu Âu. Bài báo cũng chú ý đến khả năng sử dụng tiềm năng tổng hợp sinh học của sinh khối từ các văn hóa in vitro của các loài được mô tả và các giải pháp công nghệ sinh học như một giải pháp thay thế cho nguyên liệu thực vật.
Từ khóa
Tài liệu tham khảo
Bensky D, Gamble A (1993) Chinese herbal medicine materia medica. Eastland Press, Vista
Bi H, Li F, Krausz KW et al (2013) Targeted metabolomics of serum acylcarnitines evaluates hepatoprotective effect of Wuzhi tablet (Schisandra sphenanthera extract) against acute acetaminophen toxicity. Evid Based Complement Altern Med. https://doi.org/10.1155/2013/985257
Březinová L, Vlašínová H, Havel L et al (2010) Validated method for bioactive lignans in Schisandra chinensis in vitro cultures using a solid phase extraction and a monolithic column application. Biomed Chromatogr 24:954–960. https://doi.org/10.1002/bmc.1391
Casarin E, Dall’Acqua S, Šmejkal K et al (2014) Molecular mechanisms of antiproliferative effects induced by Schisandra-derived dibenzocyclooctadiene lignans (+)-deoxyschisandrin and (−)-gomisin N in human tumour cell lines. Fitoterapia 98:241–247. https://doi.org/10.1016/j.fitote.2014.08.001
Chang J, Reiner J, Xie J (2005) Progress on the chemistry of dibenzocyclooctadiene lignans. Chem Rev 105:4581–4609. https://doi.org/10.1021/cr050531b
Chen Y-G, Wu Z-C, Lv Y-P et al (2003) Triterpenoids from Schisandra henryi with cytotoxic effect on leukemia and Hela cells in vitro. Arch Pharm Res 26:912–916. https://doi.org/10.1007/BF02980199
Chen YG, Wu ZC, Gui SH et al (2005) Lignans from Schisandra henryi with DNA cleaving activity and cytotoxic effect on leukemia and Hela cells in vitro. Fitoterapia 76:370–373. https://doi.org/10.1016/j.fitote.2005.03.012
Chen M, Kilgore N, Lee KH, Chen DF (2006) Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J Nat Prod 69:1697–1701. https://doi.org/10.1021/np060239e
Chen Y, Zhang Y, Liu Y et al (2010) A new triterpenoid acid from Schisandra henryi. Chem Natl Compd 46:480–481
Chen Y, Tang J, Wang X et al (2012) An immunostimulatory polysaccharide (SCP-IIa) from the fruit of Schisandra chinensis (Turcz.) Baill. Int J Biol Macromol 50:844–848. https://doi.org/10.1016/j.ijbiomac.2011.11.015
Chen YC, Liaw CC, Bin Cheng Y et al (2013) Anti-liver fibrotic lignans from the fruits of Schisandra arisanensis and Schisandra sphenanthera. Bioorgan Med Chem Lett 23:880–885. https://doi.org/10.1016/j.bmcl.2012.11.040
Chinese Pharmacopoeia Commission (2005) Pharmacopoeia of the People’s Republic of China. China Chemical Industry Press, Beijing
Chiu PY, Lam PY, Yan CW, Ko KM (2011) Schisandrin B protects against solar irradiation-induced oxidative injury in BJ human fibroblasts. Fitoterapia 82:682–691. https://doi.org/10.1016/j.fitote.2011.02.010
Christophe W (2013) Lead compounds from medicinal plants for the treatment of cancer, 1st edn. Elsevier, London
Connolly JD, Hill RA (2010) Triterpenoids. Nat Prod Rep 27:79–132. https://doi.org/10.1039/B808530G
Denk T, Oh IC (2005) Phylogeny of Schisandraceae based on morphological data: evidence from modern plants and the fossil record. Plant Syst Evol 256:113–145. https://doi.org/10.1007/s00606-005-0327-3
European Directorate for the Quality of Medicines (2013) Schisandra fruit. In: European Pharmacopoeia 8.0. Strasburg, p 1381
European Directorate for the Quality of Medicines (2017) Schisandra fruit. In: European Pharmacopoeia 9.0. Strasburg, p 1514
European Food Safety Authority (2010) Panel on dietetic products, nutrition and allergies 1489
Fan X, Jiang Y, Wang Y et al (2014) Wuzhi tablet (Schisandra sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos 42:1982–1990. https://doi.org/10.1124/dmd.114.059535
Fil’kin AM (1952) About Schizandra chinensis (historical-literary information). Aptechnojje Delo 2:46–48
Garnier S, Msika P (2013) Schisandra sphenanthera fruit extract and cosmetic, dermatological, and nutraceutical compositions comprising same (Patent)
Garnier S, Naaimi D, Baudouin C (2012) Cosmetic composition for the treatment of acne comprising a peptide extract of Schizandra (Patent)
Georgiev V, Schumann A, Pavlov A, Bley T (2014) Temporary immersion systems in plant biotechnology. Eng Life Sci 14:607–621. https://doi.org/10.1002/elsc.201300166
Gottlieb OR (1972) Chemosystematics of the Lauraceae. Phytochemistry 11:1537–1570. https://doi.org/10.1016/0031-9422(72)85001-5
Hancke J, Burgos R, Wikman G et al (1994) Schizandra chinensis, a potential phytodrug for recovery of sport horses. Fitoterapia 65:113–118
Hancke JL, Burgos RA, Ahumada F (1999) Schisandra chinensis (Turcz.) Baill. Fitoterapia 70:451–471. https://doi.org/10.1016/S0367-326X(99)00102-1
He F, Pu JX, Huang SX et al (2010) Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera. Org Lett 12:1208–1211. https://doi.org/10.1021/ol902974j
Hernandez DE, Hancke JL, Wikman G (1988) Evaluation of the anti-ulcer and antisecretory activity of extracts of Aralia elata root and Schizandra chinensis fruit in the rat. J Ethnopharmacol 23:109–114. https://doi.org/10.1016/0378-8741(88)90120-1
Hu D, Yang Z, Yao X et al (2014) Dibenzocyclooctadiene lignans from Schisandra chinensis and their inhibitory activity on NO production in lipopolysaccharide-activated microglia cells. Phytochemistry 104:72–78. https://doi.org/10.1016/j.phytochem.2014.04.014
Huang SX, Bin Han Q, Lei C et al (2008) Isolation and characterization of miscellaneous terpenoids of Schisandra chinensis. Tetrahedron 64:4260–4267. https://doi.org/10.1016/j.tet.2008.02.085
Huang HC, Lin YC, Fazary AE et al (2011) New and bioactive lignans from the fruits of Schisandra sphenanthera. Food Chem 128:348–357. https://doi.org/10.1016/j.foodchem.2011.03.030
Huyke C, Engel K, Simon-Haarhaus B et al (2007) Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. Planta Med 73:1116–1126. https://doi.org/10.1055/s-2007-981559
Hwang SY, Lee YJ, Lee YK et al (2009) Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Mol Med Rep 2:725–732. https://doi.org/10.3892/mmr_00000163
Hwang D, Shin SY, Lee Y et al (2011) A compound isolated from Schisandra chinensis induces apoptosis. Bioorgan Med Chem Lett 21:6054–6057. https://doi.org/10.1016/j.bmcl.2011.08.065
Iu HL, Li-jia XU, Eng YP et al (2009) Two new lignans from Schisandra henryi. Chem Pharm Bull 57:405–407. https://doi.org/10.1248/cpb.57.405
Jiang K, Song QY, Peng SJ et al (2015) New lignans from the roots of Schisandra sphenanthera. Fitoterapia 103:63–70. https://doi.org/10.1016/j.fitote.2015.03.015
Jin J, Bi H, Hu J et al (2011) Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats. Phyther Res 25:1250–1253. https://doi.org/10.1002/ptr.3407
Ko KM, Mak DH, Li PC et al (1995) Enhancement of hepatic glutathione regeneration capacity by a lignan-enriched extract of fructus Schisandrae in rats. Jpn J Pharmacol 69:439–442
Kochetkov NK, Khorlin A, Chizhov OS, Sheichenko VI (1961) Schizandrin—lignan of unusual structure. Tetrahedron Lett 2:730–734. https://doi.org/10.1016/S0040-4039(01)91684-3
Kohda H, Ozaki M, Namera A (2012) Production of lignans in calluses of Schisandra chinensis. J Nat Med 66:373–376. https://doi.org/10.1007/s11418-011-0586-y
Korea Food and Drug Administration (2002) Korean Pharmacopoeia. Seoul
Li L, Ren H, Yang X et al (2004a) Rubriflorin A and B, two novel partially saturated dibenzocyclooctene lignans from Schisandra rubriflora 19 species, mostly growing in the southwestern part of the country on mountains 1500 m. Helv Chim Acta. 87:3–7
Li L, Ren HY, Yang XD et al (2004b) Rubriflorin A and B, two novel partially saturated dibenzocyclooctene lignans from Schisandra rubriflora. Helv Chim Acta 87:2943–2947. https://doi.org/10.1002/hlca.200490265
Li R, Shen Y, Xiang W, Sun H (2004c) Four novel nortriterpenoids isolated from Schisandra henryi var. yunnanensis. Eur J Org Chem. https://doi.org/10.1002/ejoc.200300560
Li GP, Zhao JF, Tu YQ et al (2005) Chemical constituents of Schisandra rubriflora Rehd. et Wils. J Integr Plant Biol 47:362–367. https://doi.org/10.1111/j.1744-7909.2005.00085.x
Li HM, Luo YM, Pu JX et al (2008) Four new dibenzocyclooctadiene lignans from Schisandra rubriflora. Helv Chim Acta 91:1053–1062. https://doi.org/10.1002/hlca.200890113
Liang C, Hu J, Shi Y et al (2013) Schisphenlignans A–E: five new dibenzocyclooctadiene lignans from Schisandra sphenanthera. Chem Pharm Bull 61:96–100
Liu CS, Fang SD, Huang MF et al (1978) Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds. Sci Sin 21:483–502
Liu JS, Huang MF, Ayer WA, Nakashima TT (1984) Structure of enshicine from Schisandra henryi. Phytochemistry 23:1143–1145. https://doi.org/10.1016/S0031-9422(00)82627-8
Liu J-S, Tao Y, Huang M-F (1988) Studies on the constituents of Schisandra henryi. V. The structures of wulignan A1, A2, epiwulignan A1 and epischisandrone. J Chin Chem Soc 46:483–488
Liu H, Zhang J, Li X et al (2012) Chemical analysis of twelve lignans in the fruit of Schisandra sphenanthera by HPLC–PAD-MS. Phytomedicine 19:1234–1241. https://doi.org/10.1016/j.phymed.2012.07.017
Lu Y, Chen DF (2009) Analysis of Schisandra chinensis and Schisandra sphenanthera. J Chromatogr A 1216:1980–1990. https://doi.org/10.1016/j.chroma.2008.09.070
Lu H, Liu GT (1991) Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus Schizandrae on lipid peroxidation and anti-oxidative enzyme activity. Chem Biol Interact 78:77–84. https://doi.org/10.1016/0009-2797(91)90104-F
Ma J, Chikwamba R, Sparrow P et al (2005) Plant-derived pharmaceuticals—the road forward. Trends Plant Sci 10:580–585. https://doi.org/10.1016/j.tplants.2005.10.009
Miao M, Gao J, Zhang G et al (2009) Effect of Schisandra chinensis polysaccharide on intracerebral acetylcholinesterase and monoamine neurotransmitters in a d-galactose-induced aging brain mouse model. Neural Regen Res 4:687–693. https://doi.org/10.3969/j.issn.1673-5374.2009.09.009
Mu H-X, Li X-S, Fan P et al (2011) Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities. J Asian Nat Prod Res 13:393–399. https://doi.org/10.1080/10286020.2011.565748
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–479
Opletal L, Sovová H, Bártlová M (2004) Dibenzo[a, c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. J Chromatogr B 812:357–371. https://doi.org/10.1016/j.jchromb.2004.07.040
Panero JL, Aranda PD (1998) The family Schisandraceae: a new record for the flora of Mexico. Brittonia 50:87. https://doi.org/10.2307/2807721
Panossian A, Wikman G (2008) Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. J Ethnopharmacol 118:183–212. https://doi.org/10.1016/j.jep.2008.04.020
Peng Y, Duan SM, Wang YW (2015) Concise synthesis of the DEFG ring system in rubriflordilactone B. Tetrahedron Lett 56:4509–4511. https://doi.org/10.1016/j.tetlet.2015.05.117
Qin XL, Bi HC, Wang CX et al (2010a) Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr 24:399–405. https://doi.org/10.1002/bmc.1305
Qin XL, Bi HC, Wang XD et al (2010b) Mechanistic understanding of the different effects of Wuzhi tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm 389:114–121. https://doi.org/10.1016/j.ijpharm.2010.01.025
Ren R, Luo GJ, Li HM et al (2009) Schisanlactone G, a new 3,4-seco-lanostane triterpenoid from Schisandra sphenanthera. Chin Chem Lett 20:601–603. https://doi.org/10.1016/j.cclet.2008.12.053
Ren R, Ci XX, Li HZ et al (2010) New dibenzocyclooctadiene lignans from Schisandra sphenanthera and their proinflammatory cytokine inhibitory activities. Zeitschrift für Naturforsch Sect B J Chem Sci 65:211–218
Saunders RMK (ed) (2000) Monograph of Schisandra (Schisandraceae). In: Systematic botany monographs. American Society of Plant Taxonomists, pp 1–146. http://www.jstor.org/stable/25027879
Schneider M, Windbergs M, Daum N et al (2013) Crossing biological barriers for advanced drug delivery. Eur J Pharm Biopharm 84:239–241. https://doi.org/10.1016/j.ejpb.2013.03.009
Shi P, He Q, Zhang Y et al (2009) Characterisation and identification of isomeric dibenzocyclooctadiene lignans from Schisandra chinensis by high-performance liquid chromatography combined with electrospray ionisation tandem mass spectrometry. Phytochem Anal 20:197–206. https://doi.org/10.1002/pca.1115
Shi Y-M, Li X-Y, Li X-N et al (2011) Schicagenins A–C: three cagelike nortriterpenoids from leaves and stems of Schisandra chinensis. Org Lett 13:3848–3851. https://doi.org/10.1021/ol201366d
Shuwei L, Haodong C (2000) On the indications of bifendate. Advers Drug React J 2:225–228
Sun Y, Wen X, Huang H (2010) Population genetic differentiation of Schisandra chinensis and Schisandra sphenanthera as revealed by ISSR analysis. Biochem Syst Ecol 38:257–263. https://doi.org/10.1016/j.bse.2010.01.005
Szopa A, Ekiert H (2012) In vitro cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine)—a potential biotechnological rich source of therapeutically important phenolic acids. Appl Biochem Biotechnol 166:1941–1948. https://doi.org/10.1007/s12010-012-9622-y
Szopa A, Ekiert H (2016) The importance of applied light quality on the production of lignans and phenolic acids in Schisandra chinensis (Turcz.) Baill. cultures in vitro. Plant Cell Tissue Organ Cult 127:115–121. https://doi.org/10.1007/s11240-016-1034-1
Szopa A, Klimek M, Ekiert H (2016a) Chinese magnolia vine (Schisandra chinensis)—therapeutic and cosmetic importance. Pol J Cosmetol 19:274–284
Szopa A, Kokotkiewicz A, Marzec-Wróblewska U et al (2016b) Accumulation of dibenzocyclooctadiene lignans in agar cultures and in stationary and agitated liquid cultures of Schisandra chinensis (Turcz.) Baill. Appl Microbiol Biotechnol 100:3965–3977. https://doi.org/10.1007/s00253-015-7230-9
Szopa A, Ekiert R, Ekiert H (2017a) Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) as a medicinal plant species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies. Phytochem Rev 16:195–218. https://doi.org/10.1007/s11101-016-9470-4
Szopa A, Kokotkiewicz A, Luczkiewicz M, Ekiert H (2017b) Schisandra lignans production regulated by different bioreactor type. J Biotechnol 247:11–17. https://doi.org/10.1016/j.jbiotec.2017.02.007
Szopa A, Kokotkiewicz A, Król A et al (2018) Improved production of dibenzocyclooctadiene lignans in the elicited microshoot cultures of Schisandra chinensis (Chinese magnolia vine). Appl Microbiol Biotechnol 102:945–959. https://doi.org/10.1007/s00253-017-8640-7
Thandavarayan RA, Giridharan VV, Arumugam S et al (2015) Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PLoS ONE 10:e0119214. https://doi.org/10.1371/journal.pone.0119214
Umezawa T (2003) Diversity in lignan biosynthesis. Phytochem Rev 2:371–390. https://doi.org/10.1023/B:PHYT.0000045487.02836.32
Upton R, Graff A, Jolliffe G et al (2011) American herbal pharmacopoeia: botanical pharmacognosy—microscopic characterization of botanical medicines. CRC Press, Boca Raton
Verpoorte R, Contin A, Memelink J (2002) Biotechnology for the production of plant secondary metabolites. Phytochem Rev 1:13–25. https://doi.org/10.1023/A:1015871916833
Waiwut P, Shin M-S, Yokoyama S et al (2012) Gomisin A enhances tumor necrosis factor-α-induced G1 cell cycle arrest via signal transducer and activator of transcription 1-mediated phosphorylation of retinoblastoma protein. Biol Pharm Bull 35:1997–2003
Walsh G (2002) Biopharmaceuticals and biotechnology medicines: an issue of nomenclature. Eur J Pharm Sci 15:135–138. https://doi.org/10.1016/S0928-0987(01)00222-6
Walsh G (2003) Pharmaceutical biotechnology products approved within the European Union. Eur J Pharm Biopharm 55:3–10. https://doi.org/10.1016/S0939-6411(02)00165-0
Wang HJ, Chen YY (1985) Studies of lignans from Schisandra rubriflora Rhed et Wils. Acta Pharm Sin 20:832–841
Wang QY, Deng LL, Liu JJ et al (2015) Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV). Fitoterapia 101:117–124. https://doi.org/10.1016/j.fitote.2015.01.006
Wei H, Sun L, Tai Z et al (2010) A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera. Anal Chim Acta 662:97–104. https://doi.org/10.1016/j.aca.2009.12.039
Whiting DA (1985) Lignans and neolignans. Nat Prod Rep 193:191–211
Whiting DA (1990) Lignans, neolignans, and related compounds. Nat Prod Rep 7:349–364. https://doi.org/10.1039/np9900700349
World Health Organization (2007) WHO monographs on selected medicinal plants, vol 3. Fructus Schisandrae, Geneva
Wu Z, Raven P, Hong DY (2008) Flora of China, vol 7. Science Press and Missouri Botanical Garden Press, Beijing, St. Louis
Xiao W-L, Yang L-M, Gong N-B et al (2006a) Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities. Org Lett 8:991–994. https://doi.org/10.1021/ol060062f
Xiao WL, Pu JX, Chang Y et al (2006b) Sphenadilactones A and B, two novel nortriterpenoids from Schisandra sphenanthera. Org Lett 8:1475–1478. https://doi.org/10.1021/ol060324d
Xiao WL, Pu JX, Wang RR et al (2007a) Isolation and structure elucidation of nortriterpenoids from Schisandra rubriflora. Helv Chim Acta 90:1505–1513. https://doi.org/10.1002/hlca.200790157
Xiao WL, Wang RR, Zhao W et al (2007b) Triterpenoids from Schisandra rubriflora. J Nat Prod 33:1056–1059. https://doi.org/10.1007/s12272-010-0508-7
Xiao WL, Yang LM, Li LM et al (2007c) Sphenalactones A–D, a new class of highly oxygenated trinortriterpenoids from Schisandra sphenanthera. Tetrahedron Lett 48:5543–5546. https://doi.org/10.1016/j.tetlet.2007.05.152
Xiao W-L, Li R-T, Huang S-X et al (2008a) Triterpenoids from the Schisandraceae family. Nat Prod Rep 25:871. https://doi.org/10.1039/b719905h
Xiao WL, Huang SX, Wang RR et al (2008b) Nortriterpenoids and lignans from Schisandra sphenanthera. Phytochemistry 69:2862–2866. https://doi.org/10.1016/j.phytochem.2008.09.010
Xiao W-L, Wu Y-L, Shang S-Z et al (2010a) Four new nortriterpenoids from Schisandra lancifolia. Helv Chim Acta 93:1975–1982. https://doi.org/10.1002/hlca.201000004
Xiao W, Yang S-Y, Yang L-M et al (2010b) Chemical constituents from the leaves and stems of Schisandra rubriflora. J Nat Prod 73:221–225. https://doi.org/10.1021/np900849y
Xiao WL, Wang RR, Zhao W et al (2010c) Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora. Arch Pharm Res 33:697–701. https://doi.org/10.1007/s12272-010-0508-7
Xie Y, Hao H, Kang A et al (2010) Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers. J Ethnopharmacol 131:290–299. https://doi.org/10.1016/j.jep.2010.06.038
Xue Y-B, Zhang Y-L, Yang J-H et al (2010) Nortriterpenoids and lignans from the fruit of Schisandra chinensis. Chem Pharm Bull 58:1606–1611. https://doi.org/10.1248/cpb.58.1606
Xue YB, Yang JH, Li XN et al (2011) Henrischinins A–C: three new triterpenoids from Schisandra henryi. Org Lett 13:1564–1567. https://doi.org/10.1021/ol200283y
Xue XP, Qin XL, Xu C et al (2013) Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of cyclosporin A in rats. Phyther Res 27:1255–1259. https://doi.org/10.1002/ptr.4849
Yasukawa K, Ikeya Y, Mitsuhashi H et al (1992) Gomisin A inhibits tumor promotion by 12-O-tetra-decanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 49:68–71. https://doi.org/10.1159/000227014
Zhou Y, Huang S-X, Pu J-X et al (2011) Ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometric procedure for qualitative and quantitative analyses of nortriterpenoids and lignans in the genus Schisandra. J Pharm Biomed Anal 56:916–927. https://doi.org/10.1016/j.jpba.2011.07.045
Zhu M, Yeung RY, Lin KF, Li RC (2000) Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model. Planta Med 66:521–525. https://doi.org/10.1055/s-2000-11202
Zhu M, Chen XS, Wang KX (2007) Variation of the lignan content of Schisandra chinensis (Turcz.) Baill. and Schisandra sphenanthera Rehd. et Wils. Chromatographia 66:125–128. https://doi.org/10.1365/s10337-007-0261-3