SAGE Publications
1045-4411
1544-1113
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Các bài báo tiêu biểu
Matrix Metalloproteinases: A ReviewMatrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn++ endopeptidases that collectively cleave most if not all of the constituents of the extracellular matrix. The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP pre... ...
Tập 4 Số 2 - Trang 197-250 - 1993
Oral Sequelae of Head and Neck Radiotherapy In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy... ...
Tập 14 Số 3 - Trang 199-212 - 2003
The Pathogenesis of Oral Lichen Planus Both antigen-specific and non-specific mechanisms may be involved in the pathogenesis of oral lichen planus (OLP). Antigen-specific mechanisms in OLP include antigen presentation by basal keratinocytes and antigen-specific keratinocyte killing by CD8+ cytotoxic T-cells. Non-specific mechanisms include mast cell degranulation and matrix metalloproteinase (MMP) activati... ...
Tập 13 Số 4 - Trang 350-365 - 2002
Acute and Chronic Craniofacial Pain: Brainstem Mechanisms of Nociceptive Transmission and Neuroplasticity, and Their Clinical Correlates This paper reviews the recent advances in knowledge of brainstem mechanisms related to craniofacial pain. It also draws attention to their clinical implications, and concludes with a brief overview and suggestions for future research directions. It first describes the general organizational features of the trigeminal brainstem sensory nuclear complex (VBSNC), including its input and outpu... ...
Tập 11 Số 1 - Trang 57-91 - 2000
Update On Oral Lichen Planus: Etiopathogenesis and ManagementLichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteris... ...
Tập 9 Số 1 - Trang 86-122 - 1998
Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens. However, recently these drugs were found to inhibit mammalian collagenases and several other matrix metalloproteinases (MMPs) by a mechanism independent of their antimicrobial activity. Evidence is presented that this property may be the... ...
Tập 2 Số 3 - Trang 297-321 - 1991
Neurobiological Mechanisms Involved in Sleep Bruxism Sleep bruxism (SB) is reported by 8% of the adult population and is mainly associated with rhythmic masticatory muscle activity (RMMA) characterized by repetitive jaw muscle contractions (3 bursts or more at a frequency of 1 Hz). The consequences of SB may include tooth destruction, jaw pain, headaches, or the limitation of mandibular movement, as well as tooth-grinding sounds that disrup... ...
Tập 14 Số 1 - Trang 30-46 - 2003
Relation of Dental Composite Formulations To Their Degradation and the Release of Hydrolyzed Polymeric-Resin-Derived Products This article reviews the principal modes of dental composite material degradation and relates them to the specific components of the composites themselves. Particular emphasis is placed on the selection of the monomer resins, the filler content, and the degree of monomer conversion after the clinical materials are cured. Loss of mechanical function and leaching of components from the comp... ...
Tập 12 Số 2 - Trang 136-151 - 2001
Interaction of Plant Polyphenols with Salivary Proteins Tannins are polyphenols that occur widespread in plant-based food. They are considered to be part of the plant defense system against environmental stressors. Tannins have a number of effects on animals, including growth-rate depression and inhibition of digestive enzymes. Tannins also have an effect on humans: They are, for example, the cause of byssinosis, a condition that is due to exp... ...
Tập 13 Số 2 - Trang 184-196 - 2002
Dental Fluorosis : Chemistry and Biology This review aims at discussing the pathogenesis of enamel fluorosis in relation to a putative linkage among ameloblastic activities, secreted enamel matrix proteins and multiple proteases, growing enamel crystals, and fluid composition, including calcium and fluoride ions. Fluoride is the most important caries-preventive agent in dentistry. In the last two decades, increasing fluoride exp... ...
Tập 13 Số 2 - Trang 155-170 - 2002