Matrix Metalloproteinases: A Review
Tóm tắt
Matrix metalloproteinases (MMPs) are a family of nine or more highly homologous Zn++endopeptidases that collectively cleave most if not all of the constituents of the extracellular matrix. The present review discusses in detail the primary structures and the overlapping yet distinct substrate specificities of MMPs as well as the mode of activation of the unique MMP precursors. The regulation of MMP activity at the transcriptional level and at the extracellular level (precursor activation, inhibition of activated, mature enzymes) is also discussed. A final segment of the review details the current knowledge of the involvement of MMP in specific developmental or pathological conditions, including human periodontal diseases.
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Bergmann, U., J. Michaelis, R. Oberhoff, V. Knauper, R. Beckmann and H. Tschesche: Enzyme Linked Immunosorbent Assays (ELISA) for the Quantitative Determination of Human Leukocyte Collagenase and Gelatinase. J. Clin. Chem. Clin. Biochem. 27:351-359 (1989).
Bernhard, E.J., R.J. Muschel and E.N. Hughes: Mr 92,000 Gelatinase Release Correlates with the Metastatic Phenotype in Transformed Rat Embryo Cells. Cancer Res. 50:3872-3877 (1990).
Birek, P., H.M. Wang, D.M. Brunette and A.H. Melcher: Epithelial Rests of Malassez In Vitro. Lab. Invest. 43:61-72 (1980).
Birkedal-Hansen, H., C.M. Cobb, R.E. Taylor and H.M. Fullmer: Synthesis and Release of Procollagenase by Cultured Fibroblasts. J. Biol. Chem. 251:3162-3168 (1976 ).
Birkedal-Hansen, H., R.E. Taylor, A.S. Bhown, J. Katz, H.Y. Lin and B.R. Wells: Cleavage of Bovine Skin Type III Collagen by Proteolytic Enzymes. Relative Resistance of the Fibrillar Form. J. Biol. Chem. 260:16411-16417 (1985).
Bornstein, P. and W. Traub.: The Chemistry and Biology of Collagen. In: The Proteins. Vol. 4. ( H. Neurath and R. L. Hill, Eds.) pp. 411-633, Academic Press, Orlando, FL (1979 ).
Brinckerhoff, C.E., K. Suzuki, T.I. Mitchell, F. Oram, C.I. Coon, R.D. Palmiter and H. Nagase: Rabbit Procollagenase Synthesized and Secreted by High-Yield Mammalian Expression Vector Requires Stromelysin (Matrix Metalloproteinase-3) for Maximal Activation. J. Biol. Chem. 265:22262-22269 (1990 ).
Campbell, C.E., A.M. Flenniken, D. Skup and B.R.G. Williams: Identification of a Serum- and Phorbol Ester-Responsive Element in the Murine Tissue Inhibitor of Metalloproteinase Gene. J. Biol. Chem. 266:7199-7206 (1991).
Campbell, E.J., J.D. Cury, C.J. Lazarus and H.G. Welgus: Monocyte Procollagenase and Tissue Inhibitor of Metalloproteinases. Identification, Characterization, and Regulation of Secretion. J. Biol. Chem. 262:15862-15868 (1987 ).
Case, J.P., R. Lafyatis, E.F. Remmers, G.K. Kumkumian and R.L.Wilder: Transin/ Stromelysin Expression in Rheumatoid Synovium: A Transformation-Associated Metalloproteinase Secreted by Phenotypically Invasive Synoviocytes. Am. J. Pathol. 135:1055-1064 (1989 a).
Chen. J.M., R.T. Aimes, G. Ward. G.L. Youngleib and J.P. Quigley: Isolation and Characterization of a 70-kDa Metalloprotease (Gelatinase) That Is Elevated in Rous Sarcoma Virus-Transfomed Chicken Embryo Fibroblasts. J. Biol. Chem. 266:5113-5121 (1991 ).
Cheung. W. Y.: Calmodulin: An Overview. Fed. Proc. 41:2253-2257 (1982).
Chin, J.R. G. Murphy and Z. Werb: Stromelysin, A Connective Tissue-Degrading Metalloendopeptidase Secreted by Stimulated Rabbit Synovial Fibroblasts in Parallel with Collagenase. Biosynthesis. Isolation. Characterization, and Substrates. J. Biol. Chem. 260:12367-12376 (1985).
Collier, I.E., P.A. Krasnov, A.Y. Strongin, H. Birkedal-Hansen and G.I. Goldberg: Alanine Scanning Mutagenesis and Functional Analysis of the Fibronectin-Like Collagen Binding Domain from Human 92 kDa Type IV Collagenase. J. Biol. Chem. 267:6776-6781 (1992).
Collier, I.E., S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer and G.I. Goldberg: H-ras Oncogene-Transformed Human Bronchial Epithelial Cells (TBE-1) Secrete a Single Metalloprotease Capable of Degrading Basement Membrane Collagen, J. Biol. Chem. 263:6579-6587 (1988 ).
Conca, W., P.E. Auron, M. Aoun-Wathner, N. Bennett, P. Seckinger, H.G. Welgus, S.R. Goldring, S.P. Eisenberg, J.M. Dayer, S.M. Krane and L. Gehrke: An Interleukin 1β Point Mutant Demonstrates That jun/fos Expression Is Not Sufficient for Fibroblast Metalloproteinase Expression. J. Biol. Chem. 266:16265-16268 (1991).
Coulombe, B. and D. Skup: In Vitro Synthesis of the Active Tissue Inhibitor of Metalloproteinases Encoded by a Complementary DNA from Virus-Infected Murine Fibroblasts. J. Biol. Chem. 263:1439-1443 (1988 ).
Cury, J.D., E.J. Campbell, C.J. Lazarus, R.J. Albin and H.G. Welgus: Selective Up-Regulation of Human Alveolar Macrophage Collagenase Production by Lipopolysaccharide and Comparison to Collagenase Production by Fibroblasts. J. Immunol. 141:4306-4312 (1988 ).
Davis, G.E. and B.M. Martin: A Latent M, 94,000 Gelatin-Degrading Metalloproteinase Induced During Differentiation of HL-60 Promyelocytic Leukemia Cells: A Member of the Collagenase Family of Enzymes. Cancer Res. 50:1113-1120 (1990 ).
DeClerck, Y.A., T.D. Yean, H.S. Lu, J. Ting and K.E. Langley: Inhibition of Autoproteolytic Activation of Interstitial Procollagenase by Recombinant Metalloproteinase Inhibitor MI/TIMP-2. J. Biol. Chem. 266:3893-3899 (1991a).
DeClerck, Y.A., T.D. Yean, B.J. Ratzkin, H.S. Lu and K.E. Langley: Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells. J. Biol. Chem. 264:17445-17453 (1989).
DeClerck, Y.A., T.D.Yean, D. Chan, H. Shimada and K.E. Langley: Inhibition of Tumor Invasion of Smooth Muscle Cell Layers by Recombinant Human Metalloproteinase Inhibitor. Cancer Res. 51:2151-2157 (1991b).
Deporter, D.A. and A.R. Ten Cate: Fine Structural Localization of Acid and Alkaline Phosphatase in Collagen-Containing Vesicles of Fibroblasts. J. Anat. 114:457-461 (1973).
Dickson, R.B., M.C. Willingham and I. Pastan: Binding and Internalization of 125I-α2-Macroglobulin by Cultured Fibroblasts. J. Biol. Chem. 256:3454-3459 (1981 ).
Docherty, A.J.P. and G. Murphy: The Tissue Metalloproteinase Family and the Inhibitor TIMP: A Study Using cDNAs and Recombinant Proteins. Ann. Rheum. Dis. 49:469-479 (1990).
Emonard, H. and J.A. Grimaud: Matrix Metalloproteinases. A Review. Cell. Mol. Biol. 36:131-153 (1990).
Enghild, J.J., G. Salvesen, K. Brew and H. Nagase: Interaction of Human Rheumatoid Synovial Collagenase (Matrix Metalloproteinase 1) and Stromelysin (Matrix Metalloproteinase 3) with Human α2-Macroglobulin and Chicken Ovostatin, J. Biol. Chem. 264:8779-8785 (1989).
Fessler, L.I., K.G. Duncan, J.H. Fessler, T. Salo and K. Tryggvason: Characterization of Procollagen IV Cleavage Products Produced by a Specific Tumor Collagenase. J. Biol. Chem. 259:9783-9789 (1984).
Fields, G.B., H.E. Van Wart and H. Birkedal-Hansen: Sequence Specificity of Human Skin Fibroblast Collagenase. J. Biol.Chem. 262:6221-6226 (1987).
Flannery, C.R., M.W. Lark and J.D. Sandy: Identification of a Stromelysin Cleavage Site within the Interglobular Domain of Human Aggrecan. Evidence for Proteolysis at This Site In Vivo of Human Articular Cartilage. J. Biol. Chem. 267:1008-1014 (1992).
Fosang. A.J. P.J. Neame, T.E. Hardingham, G. Murphy and J.A. Hamilton. Cleavage of Cartilage Proteoglycan between G1 and G2 Domains by Stromelysins. J. Biol. Chem. 266:15279-15582 (1991).
Frisch. S.M. and H.E. Ruley: Transcription of the Stromelysin Promoter Is Induced by Interleukin-1 and Repressed by Dexamethasone, J. Biol. Chem. 262:16300-16304 (1987).
Garbisa, S., M. Ballin, D. Daga-Gordini, G. Fastelli, M. Naturale, A. Negro, G. Semenzato and L.A. Liotta: Transient Expression of Type IV Collagenolytic Metalloproteinase by Human Mononuclear Phagocytes. J. Biol. Chem. 261:2368-2375 (1986).
Garbisa, S., R. Pozzati, R.J. Muschel, U. Saffiotti, M. Ballin, R.H. Goldfarb,G. Khoury and L.A. Liotta: Secretion of Type IV Collagenolytic Protease and Metastatic Phenotype: Induction by Transfection with C-Ha-ras but Not C-Ha-ras Plus Ad2-El a. Cancer Res. 47:1523-1528 (1987 ).
Goldberg, G.I., S.M. Wilhelm, A. Kronberger, E.A. Bauer, G.E. Grant and A.Z. Eisen: Human Fibroblast Collagenase. Complete Primary Structure and Homology to an Oncogene Transformation-Induced Rat Protein. J. Biol. Chem. 261:6600-6605 (1986).
Golde, D.W., N. Bersch, S.G. Quan and A.J. Lusis: Production of Erythroid-Potentiating Activity by a Human T-Lymphoblast Cell Line. Proc. Natl. Acad. Sci. U.S.A. 77:590-595 (1980).
Golub, L. and I. Kleinberg: Gingival Crevicular Fluid: A New Diagnostic Aid in Managing the Periodontal Patient. Oral Sci. Rev. 8:49-61 (1976).
Grant, G.A., A.Z. Eisen, B.L. Marmer, W.T. Roswit and G.I. Goldberg: The Activation of Human Skin Fibroblast Procollagenase. J. Biol. Chem. 262:5886-5889 (1987).
Hasty, K.A., J.J. Jeffrey, M.S. Hibbs, and H.G. Welgus: The Collagen Substrate Specificity of Human Neutrophil Collagenase. J. Biol. Chem. 262:10048-10052 (1987 ).
Hasty, K.A., T.F. Pourmotabbed, G.I. Goldberg, J.P. Thompson, D.G. Spinella, R.M. Stevens and C.L. Mainardi: Human Neutrophil Collagenase: A Distinct Gene Product with Homology to Other Matrix Metalloproteinases. J. Biol. Chem. 265:11421-11424 (1990).
Heck, L.W., W.D. Blackburn, M.H. Irwin and D.R. Abrahamson: Degradation of Basement Membrane Laminin by Human Neutrophil Elastase and Cathepsin G. Am. J. Pathl. 136:1267-1274 (1990).
Herron, G.S., M.J. Banda, E.J. Clark, J. Gavrilovic and Z. Werb: Secretion of Metallo-Proteinases bv Stimulated Capillary Endothelial Cells. J. Biol. Chem. 261:2814-2818 (1986 ).
Hibbs, M.S., K.A. Hasty, J.M. Seyer, A.H. Kang and C.M. Mainardi: Biochemical and Immunological Characterization of the Secreted Forms of Human Neutrophil Gelatinase. J. Biol. Chem. 260:2493-2500 (1985).
Horowitz, S., N. Dafni, D.L. Shapiro, B.A. Holm, R.H. Notter and D.J. Quible: Hyperoxic Exposure Alters Gene Expression in the Lung. J. Biol. Chem. 264:7092-7095 (1989).
Hostikka. S.L. and K. Tryggvason: The Complete Primary Structure of the a2 Chain of Human Type IV Collagen and Comparison with the α1 (IV) Chain. J. Biol. Chem. 263:19488-19493 (1988).
Howard, E.W., E.C. Bullen and M.J. Banda: Preferential Inhibition of 72- and 92 kDa Gelatinases by Tissue Inhibitor of Metalloproteinases-2. J. Biol. Chem. 266:13070-13075 (1991b).
Howard. E.W., E.C. Bullen and M.J. Banda: Regulation of the Autoactivation of Human 72-kDa Progelatinase by Tissue Inhibitor of Metalloproteinases-2. J. Biol. Chem. 266:13064-13069 (1991a).
Huebner, K., M. Isobe. J.C. Gasson, D.W. Golde and C.M. Croce: Localization of the Gene Encoding Human Erythroid-Potentiating Activity to Chromosome Region Xp11.1-Xp11.4. Am. J. Human Genet. 38:819-826(1986).
Huhtala. P., A. Tuuttila, L.T. Chow, J. Lohi, J. Keski-Oja and K. Tryggvason: Complete Structure of the Human Gene for 92-kDa Type IV Collagenase. Divergent Regulation of Expression for the 92- and 72-Kilodalton Enzyme Genes in HT-1080 Cells. J. Biol. Chem. 266:16485-16490 (1991 ).
Huhtala, P. L.T. Chow and K. Tryggvason: Structure of the Human Type IV Collagenase Gene. J. Biol. Chem. 265:11077-11082 (1990a).
Janusz, M.J. and N.S. Doherty: The Degradation of Cartilage Matrix Proteoglycan by Human Neurophils Involves both Elastate and Cathepsin G. J. Immunol. 146:3922-3928 (1991).
Jeffrey, J.J.: Collagen and Collagenase: Pregnancy and Parturition. Semin. Perinatol. 15:118-126 (1991).
Johansson, S. and B. Smedsrod: Identification of a Plasma Gelatinase in Preparations of Fibronectin. J. Biol. Chem. 261:4363-4366 (1986).
Kerr, L.D., N.E. Olashaw and L.M. Matrisian: Transforming Growth Factor β1 and cAMP Inhibit Transcription of Epidermal Growth Factor- and Oncogene-Induced Transin RNA. J. Biol. Chem. 263: 16999-17005 (1988 b).
Knauper, V., S. Kramer, H. Reinke and H. Tschesche: Characterization and Activation of Procollagenase from Human Polymorphonuclear Leukocytes: N-Terminal Sequence Determination of the Proenzyme and Various Proteolytically Activated Forms. Eur. J. Biochem. 189:295-300 (1990).
Kryshtalskyj, E., J. Sodek and J.M. Ferrier: Correlation of Collagenolytic Enzymes and Inhibitors in Gingival Crevicular Fluid with Clinical and Microscopic Changes in Experimental Periodontitis in the Dog. Arch. Oral Biol. 3:21-31 (1986).
Kuter, I., B. Johnson-Wint, N. Beaupre and J. Gross: Collagenase Secretion Accompanying Changes in Cell Shape Occurs Only in the Presence of a Biologically Active Cytokine. J. Cell Sci. 92:473-485 (1989).
Laiho, M. and J. Keski-Oja: Growth Factors in the Regulation of Pericellular Proteolysis: A Review. Cancer Res. 49:2533-2553 (1989 ).
Lang, H., R.W. Glanville, P.P. Fietzek and K. Kiihn: The Covalent Structure of Calf Skin Type III Collagen. IV. The Amino Acid Sequence of the Cyanogen Bromide Peptide al(III)CB9A (Position 789-927). Hoppe-Seyler's Z. Physiol. Chem. 360:841-850 (1979).
Lecroisey, A., C. Boulard and B. Keil: Chemical and Enzymatic Characterization of the Collagenase from the Insect Hypoderma lineatum. Eur. J. Biochem. 101:385-393 (1979).
Lepage, T. and C. Gache: Early Expression of a Collagenase-Like Hatching Enzyme Gene in the Sea Urchin Embryo. EMBO J. 9:3993-3012 (1990 ).
Lin, H.Y., B.R. Wells, R.E. Taylor and H. Birkedal-Hansen: Degradation of Type I Collagen by Rat Mucosal Keratinocytes. J. Biol.Chem. 262:6823-6831 (1987).
Lotz. M. and P.A. Gueme: Interleukin-6 Induces the Synthesis of Tissue Inhibitor of Metallo-Proteinases-1/ Erythroid Potentiating Activity (TIMP-1/EPA). J. Biol. Chem. 266:2017-2020 (1991).
Mackay. A.R., J.L. Hartzler, M.D. Pelina and U.P. Thorgeirsson: Studies on the Ability of 65-kDa and 92-kDa Tumor Cell Gelatinases to Degrade Type IV Collagen. J. Biol. Chem. 265:21929-21934 (1990).
MacNaul, K.L. N. Chartrain. M. Lark, M.J. Tocci and N.I. Hutchinson: Discoordinate Expression of Stromelysin, Collagenase and Tissue Inhibitor of Metalloproteinases-1 in Rheumatoid Human Synovial Fibroblasts. Synergistic Effects of Interleukin-1 and Tumor Necrosis Factor-a on Stromelysin Expression. J. Biol. Chem. 265:17238-17245 (1990).
Mainardi. C.L. S.N. Dixit and A.H. Kang: Degradation of Type IV (Basement Membrane) Collagen by a Proteinase Isolated from Human Polymorphonuclear Leukocyte Granules. J. Biol. Chem. 255:5435-5441 (1980b).
Mainardi. C.L., D.L. Hasty, J.M. Seyer and A.H. Kang: Specific Cleavage of Human Type III Collagen by Human Polymorphonuclear Leukocyte Elastase. J. Biol. Chem. 255:12006-12010 (1980a).
Mast, A.E., J.J. Enghild, H. Nagase, K. Suzuki, S.V. Pizzo and G. Salvesen: Kinetics and Physiologic Relevance of the Inactivation of al-Proteinase Inhibitor, α1-Antichymotrypsin, and Antithrombin III by Matrix Metalloproteinases-1 (Tissue Collagenase),2 (72 kDa Gelatinase/Type IV Collagenase), and -3 (Stromelysin). J. Biol. Chem. 266:15810-15816 (1991 ).
Mawatari, M., K. Kohno, H. Mizoguchi, T. Matsuda, K. Asoh, J. van Damme, H.G. Welgus and M. Kuwano: Effects of Tumor Necrosis Factor and Epidermal Growth Factor on Cell Surface Morphology, Cell Surface Receptors, and the Production of Tissue Inhibitor of Metalloproteinases and IL-6 in Human Microvascular Endothelial Cells. J. Immunol. 143:1619-1627 (1989 ).
McCachren, S.S., B.F. Haynes and J.A. Niedel: Localization of Collagenase mRNA in Rheumatoid Arthritis Synovium by In Situ Hybridization Histochemistry. J. Clin. Invest. 10:19-27 (1990).
McCarthy, J.B., S.M. Wahl, J. Rees, C.E. Olsen, A.L. Sandberg and L.M. Wahl.: Mediation of Macrophage Collagenase Production by 3'-5' Cyclic Adenosine Monophosphate. J. Immunol. 124:2405-2409 (1980).
Miyazaki, K., Y. Hattori, F. Umenishi, H. Yasumitsu and M. Umeda: Purification and Characterization of Extracellular Matrix-Degrading Metalloproteinase, Matrin (Pump-1) Secreted from Human Rectal Carcinoma Cell Line. Cancer Res. 50:7758-7764 (1990 ).
Moll, U.M., G.L. Youngleib, K.B. Rosinski and J.P. Quigley: Tumor Promoter-Stimulated Mr 92,000 Gelatinase Secreted by Normal and Malignant Human Cells: Isolation and Characterization of the Enzyme from HT1080 Tumor Cells. Cancer Res. 50:6162-6170 (1990 ).
Moscatelli, D. and D.B. Rifkin: Membrane and Matrix Localization of Proteinases: A Common Theme in Tumor Cell Invasion and Angiogenesis. Biochim. Biophys. Acta. 948:67-85 (1988).
Murphy, G., A.J.P. Docherty, R.M. Hembry and J.J. Reynolds: Metalloproteinases and Tissue Damage. Br. J. Rheum. 30:25-31 (1991a).
Murphy, G., T.E. Cawston and J.J. Reynolds: An Inhibitor of Collagenase from Human Amniotic Fluid. Purification, Characterization, and Action on Metalloproteinases. Biochem. J. 195:67-170 (1981).
Nagase, H., R.C. Jackson, C.E. Brinckerhoff, C.A. Vater, and E.D. Harris, Jr.: A Precursor from Latent Collagenase Produced in a Cell-Free System with mRNA from Rabbit Synovial Cells. J. Biol. Chem. 256:11951- 11954 (1981).
Nagase, H. and E.D. Harris, Jr.: Ovostatin: A Novel Proteinase Inhibitor from Chicken Egg White. II. Mechanism of Inhibition Studies with Collagenase and Thermolysin. J. Biol. Chem. 258:7490-7498 (1983 ).
Nakajima, M., D.R. Welch, P.N. Belloni and G.L. Nicholson: Degradation of Basement Membrane Type IV Collagen and Lung Subendothelial Matrix by Rat Mammary Adenocarcinoma Cell Clones of Differing Metastatic Potentials. Cancer Res. 47:4869-4876 (1987 ).
Netzel-Arnett, S., G. Fields, H. Birkedal-Hansen and H.E. Van Wart: Sequence Specificities of Human Fibroblast and Neutrophil Collagenases. J. Biol. Chem. 266:6747-6755 (1991 a).
Newsome. D.A. and J. Gross: Prevention by Medroxyprogesterone of Perforation in Alkali-Burned Rabbit Cornea: Inhibition of Collagenolytic Activity. Invest. Ophthalmol. 16:21-31 (1977).
Nicholson. R.C., S. Mader. S. Nagpal, M. Leid, C. Rochette-Egly and P. Chambon: Negative Regulation of the Rat Stromelysin Gene Promoter by Retinoic Acid is Mediated by an API Binding Site EMBO J. 9:4443-4454 (1990).
Nomura, S. B.L.M. Hogan. A.J. Wills, J.K. Heath and D.R. Edwards: Developmental Expression of Tissue Inhibitor of Metalloproteinases (TIMP) RNA. Development. 105:575-584 (1989).
Ohlsson, K. I. Olsson and G. Tynelius-Bratthal: Neutrophil Leukocyte Collagenase. Elastase and Serum Protease Inhibitors in Human Gingival Crevices. Acta Odontol. Scand. 31:51-59 (1973).
Otsuka, K., J. Sodek and H. Limeback: Synthesis of Collagenase and Collagenase Inhibitors by Osteoblast-Like Cells in Culture. Eur. J. Biochem. 145:123-129 (1984).
Overall, C.M. and J. Sodek: Concanavalin A produces a Matrix-Degradative Phenotype in Human Fibroblasts. J. Biol. Chem. 265:21141-21151 (1990 ).
Overall, C.M., J.L. Wrana and J. Sodek: Transcriptional and Post-Transcriptional Regulation of 72-kDa Gelatinase/Type IV Collagenase by Transforming Growth Factor-P in Human Fibroblasts. J. Biol. Chem. 266:14064-14071 (1991 a).
Park, A.J., L.M. Matrisian, A.F. Kells, R. Pearson, Z. Yuan and M. Navre: Mutational Analysis of the Transin (Rat Stromelysin) Autoinhibitor Region Demonstrates a Role for Residues Surrounding the "Cysteine Switch". J. Biol. Chem. 266:1584-1590 (1991 ).
Petersen, M.J., D.T. Woodley, G.P. Stricklin and E.J. O'Keefe: Production of Procollagenase by Cultured Human Keratinocytes. J. Biol. Chem. 262:835-840 (1987).
Ponton, A., B. Coulombe and D. Skup: Decreased Expression of Tissue Inhibitor of Metalloproteinases in Metastatic Tumor Cells Leading to Increased Levels of Collagenase Activity. Cancer Res. 51:2138-2143 (1991 ).
Quinn, C.O., D.K. Scott, C.E. Brinckerhoff, L.M. Matrisian, J.J. Jeffrey and N.C. Partridge: Rat Collagenase. Cloning, Amino Acid Sequence Comparison, and Parathyroid Hormone Regulation in osteoblastic Cells. J. Biol. Chem. 265:22342-22347 (1990).
Reich, R., E.W. Thompson, Y. Iwamoto, G.R. Martin, J.R. Deason, G.C. Fuller and R. Miskin: Effects of Inhibitors of Plasminogen Activator, Serine Proteinases, and Collagenase IV on the Invasion of Basement Membranes by Metastatic Cells. Cancer. Res. 48:3307-3312 (1988 ).
Sakamoto, S. and M. Sakamoto: Degradative Processes of Connective Tissue Proteins with Special Emphasis on Collagenolysis and Bone Resorption. Mol. Aspects Med. 10:301-428 (1988).
Saksela, O. and D.B. Rifkin: Cell-Associated Plasminogen Activation: Regulation and Physiological Functions. Ann Rev Cell Biol 4:93-126 (1986)
Salo, T., J.G. Lyons, F. Rahemtulla, H. Birkedal-Hansen and H. Larjava: Transforming Growth Factor-β1 Up-Regulates Type IV Collagenase Expression in Cultured Human Keratinocytes. J. Biol. Chem. 266:11436-11441 (1991).
Salo, T., L.A. Liotta and K. Tryggvason: Purification and Characterization of a Murine Basement Membrane Collagen-Degrading Enzyme Secreted by Metastatic Tumor Cells. J. Biol. Chem. 258:3058-3063 (1983).
Salo, T., T. Turpeenniemi-Hujanen and K. Tryggvason: Tumor-Promoting Phorbol Esters and Cell Proliferation Stimulate Secretion of Basement Membrane (Type IV) Collagen-Degrading Metalloproteinase by Human Fibroblasts. J. Biol. Chem. 260:8526-8531 (1985).
Sanchez-Lopez, R., R. Nicholson, M.C. Gesnel, L.M. Matrisian and R. Breathnach: Structure-Function Relationships in the Collagenase Family Member Transin. J. Biol.Chem. 263:11892-11899 (1988 ).
Sandy, J.D., P.J. Neame, R.E. Boynton and C.R. Flannery: Catabolism of Aggrecan in Cartilage Explants. Identification of a Major Cleavage Site within the Interglobular Domain. J. Biol. Chem. 266:8663-8685 (1991).
Saus, J., S. Quinones, Y. Otani, H. Nagase, E.D. Harris, Jr. and M. Kurkinen: The Complete Primary Structure of Human Matrix Metalloproteinase-3. J. Biol. Chem. 263:6742-6745 (1986).
Schellens, J.P.M., V. Everts and W. Beertsen: Quantitative Analysis of Connective Tissue Resorption in the Supra-Alveolar Region of the Mouse Incisor Ligament. J. Periodont. Res. 265:13933-13938 (1982).
Schmid, T.M., R. Mayne, J.J. Jeffrey and T.F. Linsenmayer: Type X Collagen Contains Two Cleavage Sites for a Vertebrate Collagenase. J. Biol. Chem. 261:4184-4189 (1986).
Schultz, R.M., S. Silberman, B. Persky, A.S. Bajkowsky and D.F. Carmichael: Inhibition by Human Recombinant Tissue Inhibitor of Metalloproteinases of Human Amnion Invasion and Lung Colonization By Murine B16-F10 Melanoma Cells. Cancer Res. 48-5539-5545 (1988).
Seltzer, J.L., A.Z. Eisen, E.A. Bauer, N.P. Morris, R.W. Glanville and R.E. Burgeson: Cleavage of Type VII Collagen by Interstitial Collagenase and Type IV Collagenase (Gelatinase) Derived from Human Skin. J. Biol. Chem. 264:3822-3826 (1989).
Seltzer, J.L., K.T. Akers, H. Weingarten, G.A. Grant, D.W. McCourt and A.Z. Eisen: Cleavage Specificity of Human Skin Type IV Collagenase (Gelatinase). J. Biol. Chem. 265:20409-20413 (1990 ).
Seltzer, J.L., S.A. Adams, G.A. Grant and A.Z. Eisen: Purification and Properties of a Gelatin-Specific Neutral Protease from Human Skin. J. Biol. Chem. 256:4662-4668 (1981 ).
Senior. R.M., G.L. Griffin. C.J. Fliszar. S.D. Shapiro, G.I. Goldberg and H.G. Welgus: Human 92- and 72-kilodalton Type IV Collagenases are elastases. J. Biol. Chem. 266:7870-7875 (1991 ).
Shapiro. S.D., G.L. Griffin. D.J. Gilbert, N.A. Jenkins, N.G. Copeland, H.G. Welgus, R.M. Senior and T.J. Ley: Molecular Cloning, Chromosomal Localization, and Bacterial Expression of a Murine Macrophage Metalloelastase. J. Biol. Chem. 267:4664-4671 (1992).
Shen, V., G. Kohler, J.J. Jeffrey and W.A. Peck: Bone-Resorbing Agents Promote and Interferon-y Inhibits Bone Cell Collagenase Production. J. Bone Mineral Res. 3:657-666 (1988).
Sottrup-Jensen, L. and H. Birkedal-Hansen: Human Fibroblast Collagenase a-2-Macroglobulin Interactions. Localization of Cleavage Sites in the Bait Regions of Five Mammalian α-2-Macroglobulins. J. Biol. Chem. 264:393-401 (1989).
Sottrup-Jensen, L., O. Sand, L. Kristensen and G.H. Fey: The a-Macroglobulin Bait Region. Sequence Diversity and Localization of Cleavage Sites for Proteinases in Five Mammalian a-Macroglobulins. J. Biol. Chem. 264:15781-15789 (1989 ).
Sottrup-Jensen, L.: a-Macroglobulins: Structure, Shape, and Mechanism of Proteinase Complex Formation. J. Biol. Chem. 264:11539-11542 (1989 ).
Staskus, P.W., F.R. Masiarz, L.J. Pallanck and S.P. Hawkes: The 21-kDa Protein is a Transformation-Sensitive Metalloproteinase Inhibitor of Chicken Fibroblasts. J. Biol. Chem. 266:449-464 (1991).
Stetler-Stevenson, W.G., P.D. Brown, M. Onisto, A.T. Levy and L.A. Liotta: Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) mRNA expression in Tumor Cell Lines and Human Tumor Tissues. J. Biol. Chem. 265:13933-13938 (1990).
Stetler-Stevenson, W.G., H.C. Krutzsch and L.A. Liotta: Tissue Inhibitor of Metalloproteinase (TIMP-2). A New Member of the Metalloproteinase Inhibitor Family. J. Biol. Chem. 264:17374-17378 (1989b).
Stetler-Stevenson, W.G., H.C. Krutzsch, M.P. Wacher, I.M.K. Margulies and L.A. Liotta: The Activation of Human Type IV Collagenase Proenzyme. J. Biol. Chem. 264:1353-1356 (1989a).
Stricklin, G.P. and H.G. Welgus: Human Skin Fibroblast Collagenase Inhibitor. Purification and Biochemical Characterization J. Biol. Chem. 258:12252-12258 (1983).
Takada, A. and Y. Takada: Physiology of Plasminogen: with Special Reference to Activation and Degradation. Haemostasis. 18:Suppl. No. 1:24-35 (1988).
Takahashi, S., A. Ito, M. Nagino, Y. Mori, B. Xie and H. Nagase: Cyclic Adenosine 3',5'-Monophosphate Suppresses Interleukin 1-Induced Synthesis of Matrix Metalloproteinases But Not of Tissue Inhibitor of Metalloproteinases in Human Uterine Cervical Fibroblasts. J. Biol. Chem. 166:19894-19899 (1991).
Templeton, N.S., P.D. Brown, A.T. Levy, I.M.K. Margulies, L.A. Liotta and W.G. Stetler-Stevenson: Cloning and Characterization of Human Tumor Cell Interstitial Collagenase. Cancer Res. 50:5431-5437 (1990).
Tryggvason, K., M. Hoyhtya and T. Salo: Proteolytic Degradation of Extracellular Matrix in Tumor Invasion. Biochim. Biophys. Acta. 907:191-217 (1987).
Turpeenniemi-Hujanen, T., U.P. Thorgeirsson, C.N. Rao and L.A. Liotta: Laminin Increases the Release of Type IV Collagenase from Malignant Cells. J. Biol. Chem. 261:1883-1889 (1986 ).
Uitto V.J. and A. Raeste: Activation of Latent Collagenase of Human Leukocytes and Gingival Fluid by Bacterial Plaque. J. Periodont. Res. 57:844-851 (1978).
Uitto, V.J., H. Larjava, J. Heino and T. Sorsa: A Protease of Bacteroides Gingivalis Degrades Cell Surface and Matrix Glycoproteins of Cultured Gingival Fibroblasts and Induces Secretion of Collagenase and Plasminogen Activator. Infect. Immun. 57:2213-2218 (1989).
Unemori, E.N. and Z. Werb: Collagenase Expression and Endogenous Activation in Rabbit Synovial Fibroblasts Stimulated by Calcium Ionophore A23187. J. Biol. Chem. 263:16252-16259 (1988).
Unemori, E.N., K.S. Bouhana and Z. Werb: Vectorial Secretion of Extracellular Matrix Proteins, Matrix-Degrading Proteinases, and Tissue Inhibitor of Metalloproteinases by Endothelial Cells. J. Biol. Chem. 265:445-451 (1990).
Vaes, G.: Cellular Biology and Biochemical Mechanism of Bone Resorption. Clin. Orthop. Rel. Res. 231:239-271 (1988).
Van Leuven, F., J.J. Cassiman and H. Van Den Berghe: Demonstration of an α2-Macroglobulin Receptor in Human Fibroblasts, Absent in Tumor-Derived Cell Lines. J. Biol. Chem. 254:5155-5160 (1979).
Virca, G.D., G.S. Salvesen and J. Travis: Human Neutrophil Elastase and Cathepsin G Cleavage Sites in the Bait Region of α2-Macroglobulin. Hoppe-Seyler's Z. Physiol. Chem. 364:297-1302 (1983).
Virca, G.D., R.K. Mallya, M.B. Pepys and H.P. Schnebli: Quantitation of Human Leukocyte Elastase, Cathepsin G, a-2-Macroglobulin and α-1-Proteinase Inhibitor in Osteoarthrosis and Rheumatoid Arthritis Synovial Fluids. Adv. Exp. Med. Biol. 167:345-353 (1982).
Wahl, L., M.E. Corcoran, S.E. Mergenhagen and D.S. Finebloom: Inhibition of Phospholipase Activity in Human Monocytes by IFN-y Blocks Endogenous Prostaglandin E2-Dependent Collagenase Production. J. Immunol. 144:3518-3522 (1990).
Waterhouse, P., R. Khokha and D.T. Denhardt: Modulation of Translation by the 5' Leader Sequence of the mRNA Encoding Murine Tissue Inhibitor of Metalloproteinases. J. Biol. Chem. 265:5585-5589 (1990).
Welgus, H.G., C.J. Fliszar, J.L. Seltzer, T.M. Schmid and J.J. Jeffrey: Differential Susceptibility of Type X Collagen to Cleavage by Two Mammalian Interstitial Collagenases and 72-kDa Type IV Collagenase. J. Biol. Chem. 265:13521-13527 (1990 ).
Welgus, H.G., J.J. Jeffrey and A.Z. Eisen: The Collagen Substrate Specificity of Human Skin Fibroblast Collagenase. J. Biol. Chem. 256:9511-9515 (1981 ).
Welgus, H.G., J.J. Jeffrey, G.P. Stricklin and A.Z. Eisen: The Gelatinolytic Activity of Human Skin Fibroblast Collagenase. J. Biol. Chem. 257:11534-11539 (1982 ).
Welgus, H.G., J.J. Jeffrey, G.P. Stricklin, W.T. Roswit and A.Z. Eisen: Characteristics of the Action of Human Skin Fibroblast Collagenase on Fibrillar Collagen. J. Biol. Chem. 255:6806-6813 (1980).
Welgus, H.G., R.E. Burgeson, J.A.M. Wootton, R.R. Minor, C. Fliszar and J.J. Jeffrey: Degradation of Monomeric and Fibrillar Type III Collagens by Human Skin Collagenase: Kinetic Constants Using Different Animal Substrates. J. Biol. Chem. 260:1052-1059 (1985c).
Wilhelm. S.M., I.E. Collier, B.L. Marmer, A.Z. Eisen, G.A. Grant and G.I. Goldberg: SV40-Transformed Human Lung Fibroblasts Secrete a 92 kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages. J. Biol. Chem. 264:17213-17221 (1989).
Willard, H.F., S.J. Durfy, M.M. Mahtani, H. Dorkins and B.R.G. Williams: Regional Localization of the TIMP Gene on the Human X Chromosome. Human Genet. 81:234-238 (1989).
Woessner, J.F., Jr. and C.J. Taplin: Purification and Properties of a Small Latent Matrix Metalloproteinase of the Rat Uterus. J. Biol. Chem. 263:16918-16925 (1988).
Zhang, X-K., J.M. Dong and J.F. Chiu: Regulation of a-Fetoprotein Gene Expression by Antoganism between AP-1 and the Glucocorticoid Receptor at Their Overlapping Site. J. Biol. Chem. 266:8248-8254 (1991).