Update On Oral Lichen Planus: Etiopathogenesis and Management

SAGE Publications - Tập 9 Số 1 - Trang 86-122 - 1998
C Scully1, M. Beyli2, M.J. Ferreiro3, G Ficarra4, Y. Gill5, Mark Griffiths6, Palle Holmstrup7, Serdar Mutlu2, D. Walter Wray8
1Eastman Dental Institute for Oral Health Care Sciences, University of London, United Kingdom.
2Istanbul, Turkey
3Santiago de Compostela, Spain
4Florence, Italy
5Haifa, Israel
6Bristol, UK
7Copenhagen, Denmark
8Glasgow, UK

Tóm tắt

Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Tài liệu tham khảo

10.1097/00000372-199306000-00004

10.1111/j.1365-2133.1992.tb14840.x

Abramova EJ (1968). Lichen ruber planus of the oral cavity. Derm Woch 154:315-323.

10.1111/j.1600-0714.1992.tb01366.x

10.1111/j.1365-2133.1996.tb03631.x

10.14219/jada.archive.1988.0003

10.1016/0030-4220(86)90201-X

10.1016/0030-4220(87)90309-4

10.1001/archderm.1961.01580140005001

10.1016/0030-4220(68)90194-1

10.1177/106002809002400912

10.1001/archderm.1978.01640140073019

10.1016/S0190-9622(89)70299-1

10.1016/0030-4220(83)90231-1

Axell T. (1976). A prevalence study of oral mucosal lesions in an adult Swedish population. Odontol Revy 27(Suppl 36):1-103.

10.1111/j.1600-0528.1987.tb00479.x

10.1111/j.1600-0528.1987.tb00480.x

10.1111/j.1600-0536.1986.tb01276.x

10.1111/j.1600-0528.1990.tb00026.x

Ayala F., Balato N., Tranfaglia A., Guadagnino V., Orlando R. (1986). Oral erosive lichen planus and chronic liver disease. J Am Acad Dermatol 14: 139-140.

Baart de la Faille-Kuyper EH, Baart de la Faille H. (1974). An immunofluorescence study of lichen planus. Br I Dermatol 90:365-371.

10.1016/0030-4220(85)90362-7

10.1016/0278-2391(92)90354-3

Bagan JV, Donat JS, Penarrocha M., Milian MA, Sanchis JM (1993). Oral lichen planus and diabetes mellitus. A clinico-pathological study. Bull Group Int Rech Sci Stomatol et Odontol 36:3-6.

10.1016/0030-4220(94)90065-5

10.1111/j.1365-2133.1964.tb14504.x

10.1001/archderm.1989.01670220128023

10.1111/j.1600-0528.1991.tb00164.x

10.1016/0030-4220(79)90031-8

10.1016/0140-6736(91)92168-2

10.1111/j.1600-0714.1993.tb00134.x

10.1016/0030-4220(91)90468-R

10.1001/archderm.1995.01690160125028

Beck HI, Brandup F. (1986). Treatment of erosive lichen planus with dapsone. Acta Derm Venereol (Stockh) 66:366-367.

10.1111/j.1600-0714.1995.tb01158.x

Beckman BI (1981). Valisone aerosol spray contraindica-ted in mucous membranes (letter). J Am Acad Dermatol 4:233.

Bergdahl Ostman P-O., Anneroth G., Ferris FP, Skoglund A. (1995). Psychological aspects of patients with oral lichenoid reactions. Acta Odontol Scand 53:238-241.

10.1016/S0190-9622(89)80055-6

10.1001/archderm.1994.01690050077013

10.1016/0030-4220(90)90330-U

Bermejo Fenoll A., Lopez lornet MP (1991). Oral lichen planus and Sjogren's syndrome. 2 cases of association. Avances en Odontoestomatol 7:29-33, 36, 38 (in Spanish).

10.1111/j.1365-2133.1981.tb00970.x

10.1111/j.1600-0536.1993.tb03568.x

Blasberg B. Dorey JL, Stein HB, Chalmers A., Conklin RJ (1984). Lichenoid lesions of the oral mucosa in rheumatoid arthritis patients treated with penicillamine. J Rheum 11:348-351.

10.1016/0016-5085(93)91099-4

10.1016/0190-9622(92)70131-X

10.1111/j.1365-4362.1990.tb04100.x

10.1016/S1079-2104(05)80283-5

10.1016/0030-4220(90)90178-U

10.1111/j.1600-0714.1990.tb00779.x

Bollag W., Ott F. (1989). Treatment of lichen planus with temarotene. Lancet ii:974.

Bologa EL, Valda F. (1971). Ruckbildung begrifener lichen ruber planus mitnachfolgender dermatitis herpetiformis Duhring. Dermatol Monatschr 157:447-452.

10.1016/0030-4220(93)90178-7

10.1016/0030-4220(86)90422-6

10.1111/j.1365-4362.1990.tb03821.x

10.1016/0190-9622(91)70241-S

10.1016/0300-5712(95)00004-6

10.1159/000250627

10.1016/S0190-9622(80)80330-6

Brown RS, Hays GL, Flaitz CM (1993). Treatment of gold salt-induced oral lichen planus: report of a case. Cutis 51:183-185.

Bruszt P. (1962). Stomato-onkologisch reihenuntersuchungen in sieben gemeinden Sundungarns. Schweiz Monatschr Zahnheilkd 72:758-766.

10.1159/000249622

10.1016/S0190-9622(08)80367-2

10.1038/sj.bdj.4804224

10.1016/0030-4220(86)90288-4

10.1111/j.1600-0714.1986.tb00611.x

10.1136/bmj.2.5597.86

Chattopadhyay A. (1992). Arterial blood pressure and blood glucose levels in oral lichen planus patients in Calcutta (India). Indian J Dent Res 3:84-89.

10.1016/0030-4220(84)90331-1

Chen HR ( 1989). A newly developed method for treatment of oral lichen planus with ultraviolet irradiation. J Formosan Med Assoc 88:248-252.

Choudhary SD, Gupta S., lain VK ( 1988). Lichen planus hypertrophicus with carcinoma breast in a male patient (a case report). Indian J Dermatol 33:40-41.

10.1111/j.1600-0714.1977.tb01874.x

10.1111/j.1600-0714.1977.tb01875.x

10.1016/0030-4220(92)90102-V

Colvard MD, Nadimi H., Gargiulo AV (1986). Ativan (lorazepam) induced lichenoid reaction of the human attached gingiva: case report. Periodont Case Rep 8:69-70.

10.1016/S0733-8635(18)30709-5

10.1016/S0190-9622(85)70106-5

Copeman PWN, Scroeter AL, Kierland RR (1979). An unusual variant of lupus erythematosus or lichen planus. Br J Dermatol 83:269-272.

Cottoni F., Solinas A., Piga MR, Tocco A., Lissia M., Cerimele D. (1988). Lichen planus, chronic liver diseases, and immunologic involvement. Arch Dermatol Res 280(Suppl):S55-S60.

10.1001/archderm.1991.01680100134026

Cox M., Maitland N., Scully C. (1993). Human herpes simplex-I and papillomavirus type 16 homologous DNA sequences in normal, potentially malignant and malignant oral mucosa. Oral Oncol 29(B):215-219.

10.1159/000249274

10.1001/archderm.1984.01650440024011

D'Agay-Abensour L., Benamouzig R., De Belilovsky C., Cordoliani F., Halphen M., Rambaud JC (1992). Lichen planus during chronic hepatitis C treated with interferon alpha. Gastroenterol Clin Biol 16:610-611.

Daftary DK, Bhonsie RB, Musti RB, Pindborg JJ, Mehta FS (1980). An oral lichen planus-like lesion in Indian betel tobacco chewers. Scand J Dent 88:244-245.

10.1016/0030-4220(81)90124-9

Dartanel S., Sahin M., Eksioglu M., Karabay Y. (1991). Behandlung des oralen erosiven lichen planus mit topischem Cyclosporin A (Cs-A). Z Hautkr 66:148-149.

10.1111/j.1365-2133.1977.tb12536.x

10.1016/S0300-9785(84)80007-1

10.1111/j.1600-0560.1983.tb00315.x

Deasy PB, Collins AE, Burke FM, Shanley DB (1989). In vitro and in vivo evaluation of a bondable compact for the prolonged delivery of triamcinolone acetonide to the oral cavity in patients with lichen planus. Pharmaceut Acta Helv 64:276-279.

del Olmo JA, Bagan JV, Rodrigo JM, Serra MA, Wassel AH, Aparisi L., et al. (1989). Oral lichen planus and hepatic cirrhosis (letter). Ann Int Med 110:666.

10.1111/j.1440-0960.1993.tb00859.x

10.1111/j.1365-4362.1989.tb04608.x

Dinsdale RCW, Ormerod TP, Walker AE (1966). Amiphenazole sensitivity with oral ulceration. Br Dent J 121:460-462.

10.1159/000247428

10.1159/000247140

10.1159/000247552

Downham TF (1978). Spironolactone-induced lichen planus (letter). J Am Med Assoc 240:1138.

Dreyer WP (1983). The clinical manifestations of oral lichen planus. J Dent Assoc S Afr 38:619-624.

10.1111/1523-1747.ep12874626

10.1016/0278-2391(82)90321-4

Ebner H., Mischer P., Raff M. ( 1973). Lokal behandlung des lichen rubber planus der mundehlermhaut mit Vitamin A saure. Z Hautkr 48:735-740.

10.1001/archderm.1989.01670240077018

10.1177/10454411930040020101

10.1016/0190-9622(93)70082-5

10.1001/archderm.1994.01690110045004

10.1056/NEJM199008023230502

Eisen D., Griffiths CEM, Ellis CN, Nikoloff BJ, Voorhees JJ (1990b). Cyclosporin wash for oral lichen planus. Lancet 335:535-536.

10.1016/0030-4220(92)90013-G

10.1111/j.1365-2230.1993.tb00957.x

10.1038/jid.1967.23

10.1007/BF01307592

Emslie ES, Hardman FG (1970). The surgical treatment of oral lichen planus. Trans St John's Hosp Dermatol Soc 56:43-44

10.1111/j.1600-051X.1985.tb01369.x

10.1016/0030-4220(94)90312-3

10.1016/0030-4220(84)90155-5

10.1111/j.1399-302X.1994.tb00289.x

10.1016/0030-4220(88)90239-3

Falk DK, Latour DL, King LE ( 1985). Dapsone in the treatment of erosive lichen planus. J Am Acad Dermatol 12:560-570.

Farmer ER (1986). The histopathology of graft-versus-host disease. Adv Dermatol 1:173-188.

10.1111/j.1600-0714.1990.tb00801.x

10.1111/j.1600-0714.1992.tb00973.x

10.1111/j.1365-4362.1980.tb00250.x

Ferguson MM (1977). Treatment of erosive lichen planus of the oral mucosa with depot steroids. Lancet ii:771-772.

10.1016/0030-4220(84)90054-9

10.1001/archderm.1971.04000190063009

10.1016/0030-4220(93)90013-T

10.1016/S0300-9785(82)80073-2

10.1016/0030-4220(89)90300-9

Fitzgerald E., Purcell SM, Goldman HM (1995). Photodistributed hypertrophic lichen planus in association with acquired immunodeficiency syndrome: a distinct entity. Cutis 55:109-111.

Fitzpatrick TB (1963). Lichen planus-like drug eruption. Arch Dermatol 88:352.

10.1016/S0190-9622(82)70081-7

10.1159/000247742

Fortune F., Buchanan JAG (1993). Oral lichen planus and coeliac disease. Lancet 341:1154-1155.

10.1017/S0022215100148364

10.1159/000248548

10.1002/hep.1840210649

Fry L., Withers M. (1969). Lichen planus: failure to cultivate viruses or mycoplasma. Br I Dermatol 80:384.

Fryholm KO, Frithiof L., Fernstrom A., Moberger G., Blöm SF, Bjørn E. (1969). Allergy to copper derived from dental alloys as a possible cause of oral lesions of lichen planus. Acta Derm Venereol 49:268-281.

10.1001/archderm.1973.01620260017005

Gabriel SA, Jenson AB, Hartmann D., Bottomley WK (1985). Lichen planus: possible mechanisms of pathogenesis. J Oral Med 40:56-59.

10.1111/1523-1747.ep12394904

Gandolfo S., Gallo V., Carbone M., Zulian P., Carrozzo M. (1992). Oral lichen planus and liver pathology. 1. The prevalence of liver damage in a case load of 96 patients with oral lichen planus. Minerva Stomatol 41:203-207.

10.1111/j.1600-0714.1994.tb01098.x

Gart GS ( 1994). Ulcerative and oral lichen planus associated with sicca syndrome and primary biliary cirrhosis. Cutis 53:249-250.

Gibson LE, Van Hale HM, Schroeter AL (1986). Direct immunofluorescence for the study of cutaneous drug eruptions. Acta Derm Venereol (Stockh) 66:39-44.

10.1136/bmj.300.6719.227

10.1001/archderm.1991.01680040096010

Giustina TA, Stewart JCB, Ellis CE, Regezi T., Annesley T., Woo TY, et al. (1986). Topical application of isotretinoin gel improves oral lichen planus. ) J Arch Dermatol 22:534-536.

10.1016/0002-9343(73)90258-1

Gombos F., Capello B., Gaeta GM, La Rotonda MI, Serpico R., Miro A. ( 1992). La ciclosporina in formulazione bioadesiva nella terapia del lichen planus orale erosivo. Minerva Stomatol 41:385-389.

10.1016/0030-4220(92)90153-H

10.1111/j.1365-2133.1982.tb11686.x

10.1038/sj.bdj.4804036

Griffiths CEM, Nickoloff BJ (1989a). Keratinocytes intracellular adhesion molecule-1 (ICAM-1) expression precedes dermal T lymphocyte infiltration in allergic contact dermatitis (Rhus dermatitis). Am J Pathol 135:1045-1053.

10.1016/S0190-9622(89)70073-6

Grinspan D., Diaz J., Villapol LO, Schneiderman J., Berdichesky R., Palese D., et al. (1966). Lichen ruber planus de la muquense buccale. Son association a un diabete. Bull Soc Franc Dermatol Syph 73:898-899.

Groth O. ( 1961). Lichenoid dermatitis resulting from treatment with the phenothiazine derivative metopromazine and laevopromazine. Acta Derm Venereol (Stockh) 41:168-177.

10.1016/0190-9622(93)70154-L

Grupper C., Bourgeois-Spinasse J., Buisson J. (1972). Duhring-Broq disease followed by or associated with lichen planus. Bull Soc Fr Syph 79:231-232.

10.1001/archderm.1973.01620170085024

Hakala M., Van Assendelft AHW, Ilonen J., lalava S., Tiilikainen A. (1986). Association of different HLA antigens with various toxic effects of gold salts in rheumatic arthritis. Ann Rheum Dis 48:177-182.

10.1001/archderm.1983.01650290004004

10.1016/0030-4220(87)90254-4

Handler HL (1984). Isotretinoin for oral lichen planus (letter). J Am Acad Dermatol 10:674.

Hard S., Holmberg P. (1954). Penicillin treatment of lichen ruber planus. Acta Derm Venereol (Stockh) 34:72.

Harder MK, Kasha EE (1990). Pruritic zosteriform eruption. Arch Dermatol 126:665-668.

10.1016/S1079-2104(05)80195-7

10.1016/0030-4220(90)90113-7

10.1016/S0190-9622(94)70020-6

10.1111/j.1600-051X.1995.tb00150.x

Herrmann D. (1992). Karzinomentstehung bei oralem Lichen planus. Langzeituntersuchung an 919 patienten. Dtsch Zahnärtztl Z 47:877-879.

10.1111/j.1365-2133.1982.tb00904.x

Hietanen J., Pihlman K., Forstrom L., Linder E., Reunala T. (1987). No evidence of hypersensitivity to dental restorative metals in oral lichen planus. Scand J Dent Res 95:320-327.

Ho VC, Conklin RJ (1991). Effect of topical cyclosporine rinse on oral lichen planus (letter). N Engl J Med 325:435.

10.1016/0190-9622(90)70009-7

10.1016/S0190-9622(85)70166-1

10.1111/j.1600-0528.1988.tb01781.x

Holland R. (1980). Galvanic currents between gold and amalgam. Scand J Dent Res 988:269-272.

10.1111/j.1600-0714.1991.tb00878.x

10.1177/08959374920060010401

10.1016/0030-4220(92)90014-H

Holmstrup P., Dabelsteen E. (1974). The frequency of Candida in oral lichen planus. Scand J Dent Res 82:584-587.

Holmstrup P., Pindborg JJ (1979). Erythroplakic lesions in relation to oral lichen planus. Acta Dermatol (Stockh) 59(Suppl):77-84.

10.1111/j.1600-0714.1988.tb01528.x

10.1016/0030-4220(90)90241-J

10.1001/archderm.1952.01530230025003

10.1016/S0300-9785(86)80006-0

Hovick CI, Kalkwarf KL (1987). Treatment of localised oral erosive lichen planus lesions with free soft tissue grafts. Periodont Case Rep 9:21-24.

10.1111/j.1365-2133.1996.tb16224.x

10.1016/S0190-9622(81)70038-0

10.1111/j.1600-0714.1987.tb00708.x

10.1159/000247464

Itin PH, Schiller P., Gilli L., Buechner SA (1995). Isolated lichen planus of the lip. Br J Dermatol 132:1000-1002.

10.1001/archderm.1933.01450040478012

10.1111/j.1365-2230.1978.tb01465.x

10.1016/0266-4356(87)90139-2

10.1111/j.1365-2842.1990.tb00012.x

10.1902/jop.1976.47.12.724

Janner M., Muissus E., Rohde B. (1967). Lichen planus as a possible precancerous condition. Derm Woch 153: 513-518.

Jansen CT, Lehtinen R., Happonen RR, Lehtinen A., Soderlund K. (1987). Mouth PUVA: new treatment for recalcitrant oral lichen planus. Photodermatology 4:165-166.

10.1159/000246701

10.1016/0190-9622(90)70027-F

10.3109/00016356509007513

10.5694/j.1326-5377.1972.tb108041.x

10.1111/j.1834-7819.1977.tb05148.x

10.1038/sj.bdj.4805877

10.1111/j.1600-0714.1990.tb00841.x

lontell M., Hansson HA, Nygreen H. (1986). Mast cells in oral lichen planus. J Oral Pathol 15:273-275.

10.1001/archderm.1994.01690010077011

10.1016/S0901-5027(05)80001-3

lungell P., Konttinen YT, Nortamo P., Malmstrom M. (1989). Immunoelectron microscopic study of distribution of T cell subsets in oral lichen planus. Scand J Dent Res 97:361-367.

10.1159/000246637

Kaplan S., McDonald E., Marino C. (1995). Lichen planus in patient with rheumatoid arthritis treated with sulfasalazine. I Rheum 22:191-192.

10.1111/j.1600-0714.1994.tb00250.x

Kashima HK, Kutcher M., Kessis T., Levi LS, de Villiers EM, Shah K. ( 1990). Human papillomavirus in squamous cell carcinoma, leukoplakia, lichen planus and clinically normal epithelium of the oral cavity. Ann Otol Rhinol Laryngol 99:55-61.

10.1111/j.1600-051X.1988.tb01580.x

Katz M., Pisanty S. (1985). Oral erosive lichen planus and chronic active hepatitis (letter). J Am Acad Dermatol 12:719.

Kaugars GE, Svirsky JA (1982). An update on the dysplastic/carcinomatous transformation of oral lichen planus. J Oral Med 37:75-79.

Kilpi AM (1987). Activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ. Scand J Dent Res 95:174-180.

10.1111/j.1365-2133.1995.tb06915.x

Kirby AC, Olsen I., Farthing PM, Porter SR (1995). Expression of lymphocyte function-associated antigen 3 in oral lichen planus. Oral Diseases 1:193-197.

10.1177/014107688007300311

10.1016/S0190-9622(79)70015-6

10.1111/j.1600-0714.1990.tb00787.x

Konter U., Kellner I., Hoffmeister B., Sterry W. (1991). Gesteigerte expression von adhasionsmolekulen bei oralem lichen planus. Dtsch Z Mund Kiefer Gesichts Chir 15:69-74.

Konttinen YT, Jungell P., Bergroth V., Hampf G., Kamppinen P., Malmstrom M. (1989). PHA stimulation of peripheral blood lymphocytes in oral lichen planus. Abnormality localised between interleukin-2 receptor ligand formation and gamma-interferon secretion. I Clin Lab Immunol 28:33-37.

Korkij W., Chuang TY, Soltani K. 91984). Liver abnormalities in patients with lichen planus. A retrospective case-control study. J Am Acad Dermatol 1:609-615.

10.1016/S0300-9785(73)80012-2

Kristjansen A., Reymann F. (1953). ACTH therapy in lichen ruber planus. Acta Derm Venereol (Stockh) 33:205.

10.1093/carcin/8.10.1543

10.1016/0030-4220(87)90339-2

10.1016/0030-4220(85)90315-9

10.1111/j.1600-0714.1978.tb01879.x

10.1007/BF00372067

Kupriianova TA, Markov BP, Vilkova LA, Barabash AG (1989). The use of a permanent magnetic field in the combined treatment of lichen ruber planus of the oral mucosa. Stomatologiia (Mosk)(VIM) 68:33-34.

Kurgansky D., Burnett JW (1994). Widespread lichen planus in association with Turner's syndrome and multiple endocrinopathies. Cutis 54:108-110.

Kuusilehto A., Lehtinen R., Jansen CT (1990). Comparison of the minimal phototoxic dose in topical 4,5',8-trimethylpsoralen PUVA treatment of Caucasian skin and of oral mucous membrane. Acta Derm Venereol (Stockh) 70:508-509.

10.1016/0030-4220(83)90100-7

10.1016/S0190-9622(94)70018-4

10.1111/j.1365-2133.1992.tb08395.x

Lamey PJ, Boyle MA, Simpson NB, Ferguson MM (1987). A pilot study of griseofulvin therapy in erosive oral lichen planus. J Oral Med 42:233-235.

10.1016/0030-4220(90)90116-A

10.1016/S1079-2104(05)80072-1

10.1016/0030-4220(82)90461-3

10.1016/0190-9622(91)70067-C

10.1111/j.1365-2230.1996.tb00015.x

10.1111/j.1346-8138.1987.tb03598.x

Lehnhoff C. (1948). Spirochaetes in aetiologically obscure diseases. Acta Derm Venereol (Stockh) 28:295.

10.1016/S0901-5027(88)80155-3

Lehtinen R., Happonen RP, Kusilehto A., Jansen C. (1989). A clinical trial of PUVA treatment in oral lichen planus. Proc Finn Dent Soc 85:229-233.

10.1016/0140-6736(91)90418-O

Levell NJ, MacLeod RI, Marks JM (1991). Lack of effect of cyclosporin mouthwash in oral lichen planus. Lancet 337:796-797.

Lin AN Srolovitz H., Billick RC (1986). Familial lichen planus. Cutis 37:135-136.

10.1111/j.1600-0714.1990.tb00848.x

Lin SC, Sun A., Wu U-C., Chiang C.P. (1991). Presence of antibasal cell antibodies in oral lichen planus. J Am Acad Dermatol 26:943-947.

10.3109/00016358809004748

Lind PO, Hurlen B., Lyberg T., Aas E. (1986). Amalgam-related oral lichenoid reaction. Scand J Dent Res 94:448-451.

10.1001/archderm.1974.01630010057014

10.1016/S0278-2391(86)80103-3

10.1001/archderm.1989.01670170123025

10.1111/j.1365-2133.1976.tb15530.x

Lowe NJ, Cudworth AG, Woodrow JC (1976b). HLA antigens in lichen planus. Br J Dermatol 96:169-171.

Lowenthal V., Pisanti S. (1984). Oral lichen planus according to the modern medical model. J Oral Med 39:224-226.

10.1016/0030-4220(81)90258-9

10.1001/archderm.116.10.1l90

Lozada F., Silverman J., Migliorati C. (1984). Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases. J Am Dent Assoc 1091:269-270.

Lozada-Nur F., Luangjarmekorn L., Silverman S. Jr, Karam J. (1985). Assessment of plasma glucose in 99 patients with oral lichen planus. J Oral Med 40:60-61.

10.1016/0030-4220(94)90318-2

10.1016/S1079-2104(05)80255-0

Lundquist G., Forsgren H., Gajecki M., Emtestam L. (1995). Photochemotherapy of oral lichen planus: a controlled study. Oral Surg 79:554-558.

10.1016/S0300-9785(83)80060-X

10.1016/S0300-9785(84)80051-4

10.1016/S0300-9785(84)80008-3

Lundstrom WI, Anneroth GC, Bergsted HF (1982). Salivary gland function and changes in patients with oral lichen planus. Scand J Dent Res 90:443-458.

Luomanen M. (1992). Experience with a carbon dioxide laser for removal of benign oral soft-tissue lesions. Proc Finn Dent Soc 88:49-55.

10.1016/S0300-9785(75)80056-1

MacLeod RI (1992). Psychological factors in oral lichen planus (letter). Br Dent J 173:88.

MacLeod RI, Soames JV (1991). Lichen sclerosus et atrophicus of the oral mucosa. Br J Oral Maxillofac Surg 89:64-65.

Maeda H., Reibel J., Holmstrup P. (1994). Keratin staining pattern in clinical normal and diseased oral mucosa of lichen planus patients. Scand J Dent Res 102:210-215.

10.1159/000254253

10.1001/archderm.1983.01650280020008

Maibach HI (1986). Cheilitis: occult allergy to cinnamic aldehyde. Contact Dermatitis 15:106-107.

10.1038/bjc.1987.185

Maksimovskaia LN, Barashkov GN, Trestov NG (1991). The methods of modern reflexotherapy in the combined treatment of patients with erosive-ulcerative processes of the oral mucosa. Stomatologia (Mosk) 4:36-37.

Malmstrom M., Leikomaa H. (1980). Experience with cryosurgery in the treatment of oral lesions. Proc Finn Dent Soc 76:117-123.

Malmstrom M., Konttinen YT, lungell P. (1989). Lymphocyte activation in oral lichen planus. Proc Finn Dent Soc 85:109-117.

10.1111/j.1365-2133.1982.tb01736.x

10.1172/JCI115443

10.1111/j.1365-2133.1994.tb08468.x

Markitziu A., Katz J., Pisanty S. (1986). Lichenoid lesions of oral mucosa associated with ketaconazole. Mykosen 29:317-322.

10.1111/j.1365-2133.1994.tb08468.x

Massa MC, Rogers S. III (1981). Griseofulvin therapy of lichen planus. Acta Derm Venereol 61:547-550.

Matthews RW, Pinkney RC, Scully C. (1991). The management of desquamative gingivitis with dapsone. Ann Dent 48:41-43.

Matthews RW, Scully C. (1992). Griseofulvin in the treatment of oral lichen planus: adverse drug reactions but little beneficial effect. Ann Dentistry 51:10-11.

10.1111/j.1365-2133.1984.tb06629.x

10.1111/j.1600-0714.1995.tb01181.x

10.1097/00000372-198204000-00010

Meara RH (1955). Lichen planus treated with ACTH (abstract). Trans St John's Hospital Derm Soc 34:17.

10.1016/0140-6736(92)91332-3

10.1111/1523-1747.ep12277376

Miller TN (1971). Myasthenia gravis, ulcerative colitis and lichen planus. Proc R Soc Med 64:37-38.

Miralles J., Pujol RM, Moragas JM (1994). Liquen piano y hepatitis C. Descripcion de 13 casos. Actas Dermo-Sif 85:603-606.

10.1016/0140-6736(90)93101-T

10.1111/j.1600-0536.1984.tb00053.x

Mobacken H., Nilsson LA, Olsson R., Sloberg K. (1984b). Incidence of liver disease in chronic lichen planus of the mouth. Acta Derm Venereol 64:70-73.

Mobacken H., Nilsson L., Olsson R., Sloberg K. (1984c). Lichen planus and the liver (letter). Acta Dermat Venereol (Stockh) 64:570.

10.1016/S0190-9622(08)80376-3

10.1016/S0190-9622(85)80251-6

10.1016/S0190-9622(83)70035-6

10.1016/0190-9622(91)70080-L

10.1136/bmj.1.4866.856

10.1111/j.1365-2133.1956.tb12812.x

10.1111/j.1600-0714.1986.tb00580.x

10.1111/j.1365-2362.1995.tb01966.x

Nagao Y., Sata M., Tanikawa K., Kameyama T. (1995b). A case of oral lichen planus with chronic hepatitis C successfully treated by glycyrrhizin. J Jpn Assoc Infect Dis 69:940-944.

Naldi L., Sena P., Cainelli T. (1990). About the association of lichen planus and psoriasis. Dermatologica 181:9-80.

Naylor GD (1990). Treating erosive lichen planus with griseofulvin: a report of four cases. Quintessence Int 21:943-947.

10.1016/0030-4220(77)90328-0

10.1111/j.1365-2133.1980.tb07660.x

10.1097/00000372-198710000-00007

10.1159/000248835

10.1902/jop.1987.58.3.167

10.1111/j.1346-8138.1992.tb03251.x

10.1016/0190-9622(90)70085-V

Oleaga JM, Gardeazabal J., Sanz de Galdeano C., Diaz PJ ( 1995). Generalized lichen planus associated with primary biliary cirrhosis which resolved after liver transplantation (case report). Acta Derm Venereol 75:87.

10.2165/00003495-199345010-00006

Olsen RG, Du Plessis DP, Barron C., Schulz EJ, Villet W. (1983). Lichen planus dermopathy: demonstration of a lichen planus specific epidermal antigen in affected patients J Clin Lab Immunol 10:9-15.

10.1111/j.1365-2230.1986.tb00431.x

Ostman P.O, Anneroth G., Skoglund A. (1994). Oral lichen planus lesions in contact with amalgam fillings: a clinical, histologic and immunohistochemical study. Scand J Dent Res 102:172-179.

Pacor ML, Biasi D., Urbani G., Lombardo G., Lunardi C. (1994). The efficacy of cyclosporin for topical use in oral lichen planus. Minerva Stomatol 43:129-132.

10.1111/j.1365-4362.1994.tb04993.x

10.1111/1523-1747.ep12876269

10.1159/000246668

10.1002/hep.1840190407

10.1111/j.1365-2133.1995.tb02734.x

10.1093/infdis/171.6.1607

Pedersen A. (1996). Abnormal EBV immune status in oral lichen planus. Oral Diseases 2:125-128.

10.1111/j.1365-4362.1989.tb02484.x

10.1016/0030-4220(86)90100-3

10.1001/archderm.1974.01630030032006

Pindborg JJ, Mehta FS, Daftary DK, Gupta RC, Bhonsle RB (1972). Prevalence of oral lichen planus among 7639 Indian villagers in Kerala, South India. Acta Derm Venereol (Stockh) 52:216-220.

10.1111/j.1600-0714.1985.tb00549.x

10.1111/j.1600-0714.1989.tb00724.x

10.1016/0030-4220(90)90349-W

10.1016/0030-4220(93)90090-Q

10.1016/0030-4220(90)90208-A

10.1016/0030-4220(92)90379-5

Porter S., Scully C., Eveson JW (1994a). Coexistence of lichen planus and vitiligo is coincidental. Clin Exp Dermatol 19:366.

Porter SR, Scully C., Eveson JW (1994b). The efficacy of topical cyclosporin in the management of desquamative gingivitis due to lichen planus. Lancet ii:753.

10.1001/archderm.1937.01480040153011

10.1016/0030-4220(87)90029-6

10.1016/S0190-9622(84)80141-3

Powell FC, Rogers RS (1981). Primary biliary cirrhosis, penicillamine and lichen planus (letter). Lancet ii:525.

10.1111/j.1365-2133.1982.tb00416.x

Powell F., Rogers R., Dickson E. (1983). Lichen planus, primary biliary cirrhosis and penicillamine. Br J Dermatol 9:540-545.

10.1111/j.1365-2133.1986.tb02852.x

10.1111/j.1365-2133.1974.tb06719.x

10.1016/0016-5085(93)91029-H

Randell S., Cohen L. (1974). Erosive lichen planus. Management of oral lesions with intralesional corticosteroid injections. J Oral Med 29:88-91.

Rebora A. (1981). Lichen planus and the liver. Lancet ii:805-806.

10.1016/S0190-9622(84)80141-3

Rebora A., Patri P., Rampini E., Crovato F., Ciravegna G., Rebora A., et al. (1978). Erosive lichen planus and cirrhosis hepatitis. Ital Gen Rev Dermatol 15:123-131.

Rebora A., Rongioletti F., Canepa A. (1982). Chronic active hepatitis and lichen planus. Acta Derm Venereol 62:351-352.

10.1016/0923-1811(92)90054-F

10.1016/0030-4220(85)90262-2

Regezi JA, Daniels TE, Saeb F., Nickoloff BJ (1994). Increased submucosal factor Xllla-positive dendrocytes in oral lichen planus. J Oral Pathol Med 23:14-18.

10.1111/1523-1747.ep12874440

Renstrup G. (1970). Occurrence of Candida in oral leukoplakias. Acta Pathol Microbiol Scand Sect B 78:421-424.

Rich AM, Reade PC (1989). A quantitative assessment of Langerhans cells in oral mucosal lichen planus and leukoplakia. Br J Dermatol 120:223-228.

10.1111/j.1600-0560.1994.tb00691.x

10.1001/archderm.1981.01650050029015

10.1016/0030-4220(92)90380-9

10.1111/j.1600-0714.1993.tb01053.x

Roed-Petersen B., Roed-Petersen J. (1992). Occlusive treatment of atropic and erosive oral lichen planus with clobetasole proprionate 0.05% ointment. Tandl Tidsskr 1:4-7.

Roed-Petersen B., Renstrup G., Pindborg JJ (1970). Candida in oral leukoplakias. A histologic and exfoliative cytologic study. Scand J Dent Res 78:323-328.

10.1016/S0190-9622(82)70153-7

10.1016/0030-4220(90)90350-2

10.1111/j.1365-2133.1962.tb13447.x

10.1111/j.1365-2230.1986.tb00446.x

Saito K., Tamura A., Narimatsu H., Tadakuma T., Nagashima M. (1986). Cloned auto-la-reactive T cells elicit lichen planus-like lesion in the skin of syngeneic mice. J Immunol 137:2485-2495.

Sallay K. (1969). Lichen oris kexelese intrafocalisan adott hydrocortison mikrokristaly suspensioval. Fogory Szeml 62:257.

10.1016/S0190-9622(89)70026-8

10.1111/j.1600-0714.1990.tb00819.x

Samman PD (1961). Lichen planus: an analysis of 200 cases. Trans St John's Hosp 46:36.

Samman PD (1974). Discussion of thymoma, acquired hypogammaglobulinaemia, lichen planus and alopecia areata. Proc R Soc Med 67:186.

10.1111/j.1365-2133.1996.tb06977.x

Sassigneux P., Michel P., loly P., Colin R. (1993). Eruptive mucocutaneous lichen planus during treatment of chronic hepatitis C with interferon alpha. Gastroenterol Clin Biol 17:764.

10.1016/S0300-9785(85)80091-0

Saurat IH Lemarchand F., Hors J., Nunez-Roldan A., Gluckman E., Dausset J. (1977). HLA markers and lymphocytotoxins in lichen planus. Arch Dermatol 133:1719-1724.

10.1111/j.1365-2133.1958.tb13315.x

10.1016/S0030-4220(81)80010-2

Schmidt H. (1961). Frequency, duration and localization of lichen planus. Acta Derm Venereol (Stockh) 41:164-171.

10.1001/archderm.1945.01510280010002

10.1159/000250888

10.1001/archderm.1979.04010100017007

10.1111/j.1365-2230.1982.tb02404.x

10.1177/00220345820610062001

10.1111/j.1600-0714.1985.tb00516.x

Scully C., Potts J., Hamburger J., Wiesenfels S., McKee JI, El Kom M. (1984). Lichen planus and liver disease: how strong is the association? J Oral Pathol 14:224-226.

Scully C., Porter SR, Eveson JW (1993). Oral lichen planus and coeliac disease. Lancet 341:1660.

Scully C., Almeida OPD, Welbury R. (1994). Oral lichen planus in childhood. Br J Dermatol 131:131-133.

10.1001/archderm.1981.01650030018010

10.1111/j.1365-2133.1972.tb07427.x

Sharps RS (1978). Lichen planus treated with levamisole. J Cont Educ Dermatol 17:32.

10.1038/jid.1953.83

Shelley WB, Shelley ED (1989). Urinary tract infection as a cause of lichen planus: metronidazole therapy. J Am Acad Dermatol 10:905-907.

10.1159/000248355

10.1016/0030-4220(72)90467-7

10.1111/j.1365-2133.1986.tb05718.x

Sieg P., von Doarus H., von Zitzewitz V., Iven H., Farber L. (1995). Topical cyclosporin in oral lichen planus: a controlled, randomized prospective trial. Br J Dermatol 132:790-794.

10.1001/archderm.1991.01680100084009

10.1016/0030-4220(74)90135-2

10.1016/0030-4220(85)90060-X

10.1016/0030-4220(85)90210-5

10.1016/0030-4220(91)90007-Y

Simark-Mattsson C., Bergenholtz G., lontell M., Tarkowski A., Dahlgren UI (1994). T cell receptor V-gene usage in oral lichen planus: increased frequency of T cell receptors expressing Va2 and V(33. Clin Exp Immunol 98:503-507.

10.1111/j.1346-8138.1990.tb01642.x

10.1007/BF00403853

10.1007/BF00372094

10.1016/0030-4220(83)90278-5

10.1016/0030-4220(83)90304-3

Skoglund A. (1994). Value of epicutaneous patch testing in patients with oral mucosal lesions of lichenoid character. Scand J Dent Res 102:216-222.

Skoglund A., Egelrud T. (1991). Hypersensitivity reactions to dental materials in patients with lichenoid oral mucosal lesions and in patients with burning mouth syndrome. Scand J Dent Res 99:320-328.

Sleeper HR (1967). Intralesional and sublesional injection of triamcinolone acetonide for oral lichen planus. Yale J Biol Med 40:164-165.

10.1001/archderm.1979.04010060024021

10.1111/j.1600-0714.1983.tb00359.x

10.1111/j.1600-0714.1984.tb01452.x

10.1038/sj.bdj.4808663

10.1016/S0190-9622(82)80102-3

Soper DE, Patterson JW, Hurt WG, Fantl JA, Blaylock WK (1988). Lichen planus of the vulva. Obstet Gynecol 71:832-836.

Stankler L. (1975). Deficiency of circulating IgA and IgM in adult patients with lichen planus. Br J Dermatol 93:25-27.

Stankler L., Ewan SW ( 1974). The effects of experimental skin damage in patients with lichen planus. A preliminary communication. Br J Dermatol 90:25-28.

Stans ME, Bergfeld WF (1984). Treatment of oral lichen planus with low-dose isotretinoin. J Am Acad Dermatol 11:527-528.

10.1016/0030-4220(89)90137-0

10.1111/j.1365-4362.1993.tb01482.x

Stuttgen G. (1975). Oral vitamin A acid therapy. Acta Derm Venereol 55:174-175.

10.1111/j.1365-2133.1994.tb08517.x

10.1111/j.1600-0714.1995.tb01121.x

10.1111/j.1600-0714.1996.tb01375.x

Sun A., Chiang CP, Chiou PS, Wang JT, Liu BY, Wu YC (1994). Immunomodulation by levamisole in patients with recurrently aphthous ulcers or oral lichen planus. J Oral Pathol Med 4:172-177.

10.1111/j.1600-0714.1988.tb01299.x

10.14219/jada.archive.1986.0249

Tamizi M., Moayedi M. (1992). Treatment of gingival lichen planus with a free gingival graft: a case report. Quintessence Int 23:249-251.

Tan RSH (1974a). Ulcerative colitis, myasthenia gravis, atypical lichen planus, alopecia areata, vitiligo. Proc R Soc Med 67:195-196.

Tan RSH (1974b). Thymoma, acquired hypogammaglobulinaemia, lichen planus, alopecia areata. Proc R Soc Med 67:196-198.

10.1111/j.1600-0714.1992.tb00974.x

10.1111/j.1600-0714.1988.tb01527.x

10.1016/S0190-9622(08)80920-6

Torresani C., Nannini R., Bondi A., Guadagni M., Manara GC (1994). Erosive lichen planus due to sensitization to cobalt chloride. Clin Exp Dermatol 19:535-536.

10.1159/000249763

10.1016/0304-3835(94)90385-9

10.1111/j.1365-2133.1977.tb05211.x

10.1159/000248091

10.1111/j.1365-2230.1983.tb01833.x

10.1016/S1079-2104(05)80302-6

10.1016/S0733-8635(18)30718-6

Van loost T. (1974). Incidence of circulating antibodies reactive with basal cells of skin in drug reactions. Acta Derm Venereol (Stockh) 54:183-188.

10.1016/S0901-5027(87)80049-8

10.1111/j.1600-0714.1992.tb00981.x

10.1016/0030-4220(90)90112-6

10.1111/j.1600-0714.1992.tb01020.x

10.1016/0030-4220(93)90091-H

10.1016/S0190-9622(89)80197-5

10.1111/j.1600-0714.1989.tb01566.x

10.1111/j.1600-0714.1990.tb00820.x

10.1111/j.1600-0714.1990.tb00866.x

10.1111/j.1600-0714.1994.tb00056.x

10.1111/j.1365-2133.1988.tb03194.x

Watanabe C., Hayashi T., Kawada A. (1991). Immunofluorescence study of drug-induced lichen planus-like lesions. J Dermatol 8:473-477.

Weidan AL (1963). Treatment of psoriasis and other dermatoses with intralesional injections of triamcinolone acetonide. Curr Ther Res 5:7.

10.1016/0030-4220(82)90191-8

Wiles JC, Lynch P.] (1984). Lichen planus and liver disease. J Am Acad Dermatol 10:671-672.

10.1111/j.1365-2230.1994.tb01174.x

Woo TY (1985). Systemic isotretinoin treatment of oral and cutaneous lichen planus. Cutis 35:385-393.

10.1016/0030-4220(87)90114-9

10.1111/j.1600-0714.1990.tb00788.x

10.1111/j.1600-0714.1991.tb00927.x

10.1111/j.1600-0714.1994.tb00067.x

Zegarelli D. (1980). Topical intralesional steroid therapy of oral lichen planus. NY State Dent J 46:432.

Zegarelli DJ (1983). Multimodality steroid therapy of erosive and ulcerative oral lichen planus. J Oral Med 38:127-130.

Zegarelli DI (1984). Treatment of oral lichen planus with topical vitamin A acid. J Oral Med 39:186-191.

Zegarelli F., Kutscher A., Mehrhof A. (1969). Long-lasting lozenges with triamcinolone acetonide. NY State J Med 69:2463-2464.

10.1016/S0190-9622(85)80448-5