Interaction of Plant Polyphenols with Salivary Proteins

SAGE Publications - Tập 13 Số 2 - Trang 184-196 - 2002
Anders Bennick1
1Department of Biochemistry and Faculty of Dentistry, University of Toronto, 1 King's College Circle, Toronto M5S 1A8, Ontario, Canada;

Tóm tắt

Tannins are polyphenols that occur widespread in plant-based food. They are considered to be part of the plant defense system against environmental stressors. Tannins have a number of effects on animals, including growth-rate depression and inhibition of digestive enzymes. Tannins also have an effect on humans: They are, for example, the cause of byssinosis, a condition that is due to exposure to airborne tannin. Their biological effect is related to the great efficiency by which tannins precipitate proteins, an interaction that occurs by hydrophobic forces and hydrogen bonding. Two groups of salivary proteins, proline-rich proteins and histatins, are highly effective precipitators of tannin, and there is evidence that at least proline-rich proteins act as a first line of defense against tannins, perhaps by precipitating tannins in food and preventing their absorption from the alimentary canal. Proline plays an important role in the interaction of proline-rich proteins with tannins. In contrast, it is primarily basic residues that are responsible for the binding of histatins to tannin. The high concentration of tannin-binding proteins in human saliva may be related to the fruit and vegetable diet of human ancestors.

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Tài liệu tham khảo

10.1079/BJN19910080

10.1098/rstb.1991.0109

10.1159/000259749

10.1016/0003-9969(74)90055-7

10.1016/S0031-9422(00)81214-5

10.1021/jf00075a012

10.1007/BF01014834

10.1007/BF00487820

Azen EA, Maeda N (1988). Molecular genetics of human salivary proteins and their polymorphisms. In: Advances in human genetics. Harris H, Hirschorn K, editors. New York: Plenum, pp. 141-199.

10.1038/273775a0

10.1128/IAI.61.10.4434-4439.1993

10.1021/jf990820z

10.1016/S0065-2628(08)60224-4

10.1021/bi9700328

Becklake MR (1980). Grain dust and health: state of the art. In: Occupational pulmonary disease. Focus on grain dust and health. Dosman JD, Cotton DJ, editors. New York: Academic Press, pp 189-200.

10.1042/bj1230455

10.1042/bj1830115

10.1016/S0021-9258(19)69314-2

10.1016/0003-9969(83)90022-5

10.1097/00010694-196804000-00001

Boyd EM, Bereczky K, Godi I (1965). The acute toxicity of tannic acid administered intragastrically. Can Med Assoc J 92:1292–1297.

Brune M, Rossander L, Hallberg L (1989). Iron absorption and phenolic compounds: importance of different phenolic structures. Eur J Clin Nutr 43:547–557.

10.1046/j.1432-1327.2001.02241.x

10.1093/jn/124.2.283

10.1016/0014-5793(96)00186-X

10.1016/0003-9969(63)90076-1

Cotes JE, Steel J, Leathart GL (1987). Work-related lung disorders. Oxford: Blackwell Scientific Publishers, pp. 309-319.

10.1016/S0021-9258(17)42380-5

10.1021/jf000981z

10.1016/0014-5793(75)80071-8

Dickinson DP, Thiesse M (1995). A major human lacrimal gland mRNA encodes a new proline-rich protein family member. Invest Ophthalmol Vis Sci 36:2020–2031.

10.3109/02713689608995828

10.1097/00000658-194302000-00010

Featherstone WR, Rogler JC (1975). Influence of tannins on the utilization of sorghum grain by rats and chicks. Nutr Rep Int 11:491–497.

10.1016/0006-291X(74)90198-3

10.1007/s003600050144

Friedman R, Merritt AD (1975). Partial purification and characterization of a polymorphic protein (Pa) in human parotid saliva. Am J Hum Genet 27:304–314.

10.1016/0304-4165(71)90193-0

10.1128/IAI.56.11.2990-2993.1988

10.1128/IAI.59.9.2948-2954.1991

10.1016/S0021-9258(19)47381-X

10.1016/0091-7435(92)90041-F

10.1007/978-1-4757-0022-0_29

10.1002/jsfa.2740310307

10.1111/j.1399-302X.1995.tb00118.x

10.1021/jf60218a027

10.1021/jf60231a010

10.1016/S0021-9258(19)69462-7

Hagerman AE, Klucher KM (1986). Tannin-protein interactions. Prog Clin Biol Res 213:67–76.

10.1007/BF01020552

10.1139/z93-085

10.1021/jf971097k

Harborne JB, Simmonds NW (1964). The natural distribution of the phenolic aglycones. In: Biochemistry of phenolic compounds. Harborne J, editor. New York: Academic Press, pp. 77-127.

10.2134/agronj1970.00021962006200060051x

10.2134/agronj1973.00021962006500060033x

Haslam E, Lilley TH, Warminski E, Liao H, Cai Y, Martin R, et al. (1991). Polyphenol complexation. A study in molecular recognition. In: Phenolic compounds in food and their effects on health. I. Analysis, occurrence and chemistry. Ho C-T, Lee CY, Huang M-T, editors. Washington, DC: Am Chem Soc, pp. 8-49.

10.1042/bj2300817

Hay DI, Moreno EC, Schlesinger DH (1979). Phosphoprotein-inhibitors of calcium phosphate precipitation in human saliva. Inorg Persp Biol Med 2:271–285.

10.1042/bj2550015

10.1007/BF01027170

10.1080/01635589309514267

10.1079/BJN19880099

10.1093/oxfordjournals.jbchem.a022620

10.1093/oxfordjournals.jbchem.a021689

Isemura S, Saitoh E, Sanada K (1979). Isolation and amino acid sequences of proline-rich peptides of human whole saliva. J Biochem 86:79–86.

Isemura T, Asakura J, Shibata S, Isemura S, Saitoh E, Sanada K (1983). Conformational study of the salivary proline-rich polypeptides. Int J Peptide Protein Res 21:281–287.

10.1021/jf60188a027

10.1053/meta.2001.21037

10.1021/jf00040a024

10.1093/jn/98.1.119

10.1016/S0950-3293(00)00040-9

10.1021/jf00072a009

10.1128/iai.65.8.3159-3164.1997

10.1016/0003-9969(79)90085-2

10.1021/bi00268a036

10.1021/bi00357a013

10.1021/bi00228a001

10.1177/10454411930040030501

Kreofsky TJ, Russell JA, Rohrbach MS (1990). Inhibition of alveolar macrophage spreading and phagocytosis by cotton bract tannin. Am J Path 137:263–274.

10.1159/000399407

Lauque DE, Hempel SL, Schroeder MA, Hyatt RE, Rohrbach MS (1988). Evaluation of the contribution of tannin to the acute pulmonary inflammatory response against inhaled cotton mill dust. Am J Patho 133:163–172.

10.1016/0003-9969(77)90137-6

10.1016/0005-2795(69)90060-9

Lin HH, Tu ZJ, Ann DK (1996). Involvement of nuclear orphan receptor NGFI-B in transcriptional activation of salivary-specific R15 gene by cAMP. J Biol Chem 44:27637–27644.

10.1016/S0003-9969(98)00040-5

10.1016/0031-9422(94)85061-5

Lucke HH, Hodge KE, Patt NL (1963). Fatal liver damage after barium enemas containing tannic acid. Can Med Assoc J 89:1111–1114.

10.1093/genetics/120.1.255

10.1093/genetics/120.1.267

10.1042/bj2700297

Madapallimattam G, Limeback H, Bennick A (1992). Immunological relationship of porcine amelogenins and salivary proline-rich proteins (abstract). J Dent Res 71(Spec Iss):732.

10.1007/BF00499086

10.1002/jsfa.2740280815

10.1139/z93-314

10.1128/IAI.44.3.695-701.1984

McManus JP, Davis KD, Beart JE, Gaffney SH, Lilley TH, Haslam E (1985). Polyphenol interactions. Part 1. Introduction: some observations on the reversible complexation of polyphenols with proteins and polysaccharides. J Chem Soc Perkin Trans II 1429–1438.A

10.1073/pnas.80.13.3948

10.1016/S0021-9258(18)89281-X

10.1146/annurev.nu.07.070187.002231

10.1016/S0021-9258(18)45359-8

Middleton E Jr, Kandaswami C (1994). The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: The flavonoids. Advances since 1986. Harborne JB, editor. London: Chapman and Hall, pp. 619-645.

10.1177/00220345890680010201

10.1093/jn/107.12.2113

10.1016/S0021-9258(19)81061-X

10.1016/S0021-9258(18)50460-9

Mundie TG, Whitener C, Ainsworth SK (1985). Byssinosis: release of prostaglandins, thromboxane and 5-hydroxytryptamine in broncho-pulmonary lavage fluids after inhalation of cotton dust extract. Am J Pathol 118:128–133.

10.1111/j.1432-1033.1994.tb18573.x

10.1111/j.1432-1033.1994.tb18574.x

10.1128/IAI.60.1.31-38.1992

10.1021/jf981044i

O'Sullivan JM, Cannon RD, Sullivan PA, Jenkinson JF (1997). Identification of salivary basic proline-rich proteins as receptors for Candida albicans adhesion. Micobiology 143:341–348.

10.1021/jf60228a020

10.1021/bi00799a013

10.1016/0003-9969(79)90019-0

10.1016/S0021-9258(17)36072-6

10.1128/IAI.44.3.702-707.1984

10.1016/S0021-9258(19)39678-4

10.1016/0003-9969(83)90140-1

10.1002/jsfa.2740330116

10.2307/1938809

Rohrbach MS, Kreofsky TJ, Vuk-Palovic Z, Lauque D (1992). Cotton condensed tannin: a potent modulator of alveolar macrophage host defence function. Basic Life Sci 59:803–824.

10.3382/ps.0520765

10.1016/0006-291X(89)92460-1

10.1177/00220345890680070101

10.1093/oxfordjournals.jbchem.a134553

Salunkhe DK, Chavan JK, Kadam SS, editors (1990). Dietary tannins: consequences and remedies. Boca Raton: CRC Press Inc.

10.1021/jf9805146

10.1016/S0003-9969(97)00045-9

Shibata S, Asakura J, Isemura T, Isemura S, Saitoh E, Sanada K (1984). Conformational study of the basic proline-rich polypeptides from human parotid saliva. Int J Peptide Protein Res 23:158–165.

10.1021/jf9502459

10.1016/S0003-9969(98)00068-5

10.1021/jf00120a039

10.1016/0378-4347(93)80121-J

10.2134/agronj1970.00021962006200020010x

10.1177/00220345900690010101

Warner TF, Azen EA (1984). Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract. Am Rev Resp Dis 130:115–118.

Waters CA, Morand JN, Schatzman RC, Carlson DM (1998). Induction of p34cdc2 in mouse parotid glands upon activation of beta1-adrenergic receptors. Cell Mol Biol 44:333–342.

10.1016/S0021-9258(19)70721-2

10.1016/S0021-9258(17)30083-2

10.1042/bj2110035

Wroblewski K, Muhandiram R, Chakrabarrty A, Bennick A (2001). The molecular interaction of human salivary histatins with polyphenolic compounds. Eur J Biochem 262:428–437.

Wünsch P, del Vedovo S, Rosset J, Smiley M (1984). The tannin granules from ripe carob pod. Lebens Wiss Techonol 17:351–354.

10.1016/0003-9969(93)90133-7

10.1042/bj3110341

10.1086/284065

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SAGE Publications

Tập 13 Số 2

184-196

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