Interaction of Plant Polyphenols with Salivary Proteins
Tóm tắt
Tannins are polyphenols that occur widespread in plant-based food. They are considered to be part of the plant defense system against environmental stressors. Tannins have a number of effects on animals, including growth-rate depression and inhibition of digestive enzymes. Tannins also have an effect on humans: They are, for example, the cause of byssinosis, a condition that is due to exposure to airborne tannin. Their biological effect is related to the great efficiency by which tannins precipitate proteins, an interaction that occurs by hydrophobic forces and hydrogen bonding. Two groups of salivary proteins, proline-rich proteins and histatins, are highly effective precipitators of tannin, and there is evidence that at least proline-rich proteins act as a first line of defense against tannins, perhaps by precipitating tannins in food and preventing their absorption from the alimentary canal. Proline plays an important role in the interaction of proline-rich proteins with tannins. In contrast, it is primarily basic residues that are responsible for the binding of histatins to tannin. The high concentration of tannin-binding proteins in human saliva may be related to the fruit and vegetable diet of human ancestors.
Từ khóa
Tài liệu tham khảo
Azen EA, Maeda N (1988). Molecular genetics of human salivary proteins and their polymorphisms. In: Advances in human genetics. Harris H, Hirschorn K, editors. New York: Plenum, pp. 141-199.
Becklake MR (1980). Grain dust and health: state of the art. In: Occupational pulmonary disease. Focus on grain dust and health. Dosman JD, Cotton DJ, editors. New York: Academic Press, pp 189-200.
Boyd EM, Bereczky K, Godi I (1965). The acute toxicity of tannic acid administered intragastrically. Can Med Assoc J 92:1292–1297.
Brune M, Rossander L, Hallberg L (1989). Iron absorption and phenolic compounds: importance of different phenolic structures. Eur J Clin Nutr 43:547–557.
Cotes JE, Steel J, Leathart GL (1987). Work-related lung disorders. Oxford: Blackwell Scientific Publishers, pp. 309-319.
Dickinson DP, Thiesse M (1995). A major human lacrimal gland mRNA encodes a new proline-rich protein family member. Invest Ophthalmol Vis Sci 36:2020–2031.
Featherstone WR, Rogler JC (1975). Influence of tannins on the utilization of sorghum grain by rats and chicks. Nutr Rep Int 11:491–497.
Friedman R, Merritt AD (1975). Partial purification and characterization of a polymorphic protein (Pa) in human parotid saliva. Am J Hum Genet 27:304–314.
Hagerman AE, Klucher KM (1986). Tannin-protein interactions. Prog Clin Biol Res 213:67–76.
Harborne JB, Simmonds NW (1964). The natural distribution of the phenolic aglycones. In: Biochemistry of phenolic compounds. Harborne J, editor. New York: Academic Press, pp. 77-127.
Haslam E, Lilley TH, Warminski E, Liao H, Cai Y, Martin R, et al. (1991). Polyphenol complexation. A study in molecular recognition. In: Phenolic compounds in food and their effects on health. I. Analysis, occurrence and chemistry. Ho C-T, Lee CY, Huang M-T, editors. Washington, DC: Am Chem Soc, pp. 8-49.
Hay DI, Moreno EC, Schlesinger DH (1979). Phosphoprotein-inhibitors of calcium phosphate precipitation in human saliva. Inorg Persp Biol Med 2:271–285.
Isemura S, Saitoh E, Sanada K (1979). Isolation and amino acid sequences of proline-rich peptides of human whole saliva. J Biochem 86:79–86.
Isemura T, Asakura J, Shibata S, Isemura S, Saitoh E, Sanada K (1983). Conformational study of the salivary proline-rich polypeptides. Int J Peptide Protein Res 21:281–287.
Kreofsky TJ, Russell JA, Rohrbach MS (1990). Inhibition of alveolar macrophage spreading and phagocytosis by cotton bract tannin. Am J Path 137:263–274.
Lauque DE, Hempel SL, Schroeder MA, Hyatt RE, Rohrbach MS (1988). Evaluation of the contribution of tannin to the acute pulmonary inflammatory response against inhaled cotton mill dust. Am J Patho 133:163–172.
Lin HH, Tu ZJ, Ann DK (1996). Involvement of nuclear orphan receptor NGFI-B in transcriptional activation of salivary-specific R15 gene by cAMP. J Biol Chem 44:27637–27644.
Lucke HH, Hodge KE, Patt NL (1963). Fatal liver damage after barium enemas containing tannic acid. Can Med Assoc J 89:1111–1114.
Madapallimattam G, Limeback H, Bennick A (1992). Immunological relationship of porcine amelogenins and salivary proline-rich proteins (abstract). J Dent Res 71(Spec Iss):732.
McManus JP, Davis KD, Beart JE, Gaffney SH, Lilley TH, Haslam E (1985). Polyphenol interactions. Part 1. Introduction: some observations on the reversible complexation of polyphenols with proteins and polysaccharides. J Chem Soc Perkin Trans II 1429–1438.A
Middleton E Jr, Kandaswami C (1994). The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: The flavonoids. Advances since 1986. Harborne JB, editor. London: Chapman and Hall, pp. 619-645.
Mundie TG, Whitener C, Ainsworth SK (1985). Byssinosis: release of prostaglandins, thromboxane and 5-hydroxytryptamine in broncho-pulmonary lavage fluids after inhalation of cotton dust extract. Am J Pathol 118:128–133.
O'Sullivan JM, Cannon RD, Sullivan PA, Jenkinson JF (1997). Identification of salivary basic proline-rich proteins as receptors for Candida albicans adhesion. Micobiology 143:341–348.
Rohrbach MS, Kreofsky TJ, Vuk-Palovic Z, Lauque D (1992). Cotton condensed tannin: a potent modulator of alveolar macrophage host defence function. Basic Life Sci 59:803–824.
Salunkhe DK, Chavan JK, Kadam SS, editors (1990). Dietary tannins: consequences and remedies. Boca Raton: CRC Press Inc.
Shibata S, Asakura J, Isemura T, Isemura S, Saitoh E, Sanada K (1984). Conformational study of the basic proline-rich polypeptides from human parotid saliva. Int J Peptide Protein Res 23:158–165.
Warner TF, Azen EA (1984). Proline-rich proteins are present in serous cells of submucosal glands in the respiratory tract. Am Rev Resp Dis 130:115–118.
Waters CA, Morand JN, Schatzman RC, Carlson DM (1998). Induction of p34cdc2 in mouse parotid glands upon activation of beta1-adrenergic receptors. Cell Mol Biol 44:333–342.
Wroblewski K, Muhandiram R, Chakrabarrty A, Bennick A (2001). The molecular interaction of human salivary histatins with polyphenolic compounds. Eur J Biochem 262:428–437.
Wünsch P, del Vedovo S, Rosset J, Smiley M (1984). The tannin granules from ripe carob pod. Lebens Wiss Techonol 17:351–354.