Royal Society of Chemistry (RSC)

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Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors
Royal Society of Chemistry (RSC) - Tập 9 Số 5 - Trang 853-861
Zhaojun Sheng, Si-Yuan Ge, Ximing Xu, Yan Zhang, Panpan Wu, Kun Zhang, Xue-Tao Xu, Chen Li, Deng‐Gao Zhao, Xiaowen Tang
Tyrosinase is a key enzyme in melanin biosynthesis, and is also involved in the enzymatic browning of plant-derived foods.
Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity
Royal Society of Chemistry (RSC) - Tập 9 Số 3 - Trang 534-544
Silvia Roscales, Nicole Bechmann, Daniel Holger Weiß, Martin Köckerling, Jens Pietzsch, Torsten Knieß
By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.
Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)
Royal Society of Chemistry (RSC) - Tập 8 Số 3 - Trang 492-500
Gabriele Carullo, F. Galligano, Francesca Aiello
An original point of view inside the SAR studies to develop new selective COX-2 inhibitors.
Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents
Royal Society of Chemistry (RSC) - Tập 4 Số 7 - Trang 1073 - 2013
Narsimha Reddy Penthala, Vijayakumar N. Sonar, Jamie Horn, Markos Leggas, Jai Shankar K. Yadlapalli, Peter A. Crooks
Synthesis and biological evaluation of coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors
Royal Society of Chemistry (RSC) - Tập 5 Số 5 - Trang 650-654
Xian-Wei Ye, Yi‐Chao Zheng, Ying‐Chao Duan, Mengmeng Wang, Bin Yu, Jingli Ren, Jinlian Ma, En Zhang, Hong‐Min Liu
Design of novel coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors by introducing a coumarin scaffold.
Synthesis and cytotoxicity evaluation of regioisomeric substituted N-phenyl-3′-(chrom-4-one-3-yl)-isoxazolidines: induction of apoptosis through a mitochondrial-dependent pathway
Royal Society of Chemistry (RSC) - Tập 4 Số 6 - Trang 972 - 2013
Gagandeep Singh, Amritpal Kaur, Vishal Sharma, Nitasha Suri, Parduman Raj Sharma, Ajit Kumar Saxena, Mohan Paul S. Ishar
Druggability assessment of mammalian Per–Arnt–Sim [PAS] domains using computational approaches
Royal Society of Chemistry (RSC) - Tập 10 Số 7 - Trang 1126-1137
João Vicente Braga de Souza, Sylvia Reznikov, Ruidi Zhu, Agnieszka K. Bronowska
Protein dynamics finely tune the “druggability” of mammalian PAS-B domains, as assessed by atomistic molecular dynamics simulations and hotspot mapping.
Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles
Royal Society of Chemistry (RSC) - Tập 7 Số 8 - Trang 1555-1563
Samara Ben B. B. Bahia, Wallace J. Reis, Guilherme A. M. Jardim, Francielly T. Souto, Carlos A. de Simone, Claudia C. Gatto, Rubem F. S. Menna‐Barreto, Solange L. de Castro, Bruno C. Cavalcanti, Cláudia Pessoa, Maria H. Araújo, Eufrânio N. da Silva Júnior
Some of the hybrid compounds exhibited promising trypanocidal and anticancer activities.
Antivascular and anticancer activity of dihalogenated A-ring analogues of combretastatin A-4
Royal Society of Chemistry (RSC) - Tập 1 Số 3 - Trang 202 - 2010
Thomas M. Beale, R. M. Myers, J.W. Shearman, D. Stephen Charnock‐Jones, James D. Brenton, Fanni Gergely, Steven V. Ley
N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK
Royal Society of Chemistry (RSC) - Tập 9 Số 6 - Trang 963-968
Agnese Chiara Pippione, Stefano Sainas, Antonella Federico, Elisa Lupino, Marco Piccinini, Michael H.G. Kubbutat, Jean‐Marie Contreras, Christophe Morice, Alessandro Barge, Alex Ducime, Donatella Boschi, Salam Al‐Karadaghi, Marco L. Lolli
Resulting from hit-to-lead optimization, the aminopyrazole3ais a NIK inhibitor selective over 44 kinases.
Tổng số: 26   
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