Royal Society of Chemistry (RSC)
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Compared to carbocyclic drug molecules, pyridazine-containing drugs present additional interaction possibilities, as illustrated here for the antirhinoviral agent R 61837.
Protein dynamics finely tune the “druggability” of mammalian PAS-B domains, as assessed by atomistic molecular dynamics simulations and hotspot mapping.
Tumor cell resistance to drug treatment severely limits the therapeutic success of treatment.
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An original point of view inside the SAR studies to develop new selective COX-2 inhibitors.
New lipophilic hydroxycinnamic acid based derivatives were designed and synthesized and their antioxidant and neuroprotective activities evaluated.
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