N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

Royal Society of Chemistry (RSC) - Tập 9 Số 6 - Trang 963-968
Agnese Chiara Pippione1,2,3,4, Stefano Sainas1,2,3,4, Antonella Federico1,2,3,4, Elisa Lupino5,6,3,4, Marco Piccinini5,6,3,4, Michael H.G. Kubbutat7,8,9, Jean‐Marie Contreras10,11,12, Christophe Morice10,11,12, Alessandro Barge1,2,3,4, Alex Ducime1,2,3,4, Donatella Boschi1,2,3,4, Salam Al‐Karadaghi13,14, Marco L. Lolli1,2,3,4
110125 Torino
2Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy
3Italy
4University of Torino
510126 Torino
6Department of Oncology, University of Torino, via Michelangelo 27/B, 10126 Torino, Italy
779106 Freiburg
8Germany
9ProQinase GmbH, Breisacher Str. 117, 79106 Freiburg, Germany
1067400 Illkirch
11France
12Prestwick Chemical, 220 Boulevard Gonthier d'Andernach, 67400 Illkirch, France
13SARomics Biostructures, Lund, Sweden
14Sweden

Tóm tắt

Resulting from hit-to-lead optimization, the aminopyrazole3ais a NIK inhibitor selective over 44 kinases.

Từ khóa


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