Novel valdecoxib derivatives by ruthenium(<scp>ii</scp>)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes – synthesis and COX-2 inhibition activity

Royal Society of Chemistry (RSC) - Tập 9 Số 3 - Trang 534-544
Silvia Roscales1,2,3,4,5, Nicole Bechmann1,2,3,4,5, Daniel Holger Weiß6,7,3,8,9, Martin Köckerling6,7,3,8,9, Jens Pietzsch1,2,3,4,5, Torsten Knieß1,2,3,4,5
101328 Dresden
2Department of Radiopharmaceutical and Chemical Biology
3Germany
4Helmholtz-Zentrum Dresden-Rossendorf
5Institute of Radiopharmaceutical Cancer Research
618059 Rostock
7Department of Inorganic Solid State Chemistry
8Institute of Chemistry
9University of Rostock

Tóm tắt

By Ru(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes 3,4-diaryl-substituted isoxazoles are formed in one step, showing high inhibition potency for COX-2.

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