Are pyridazines privileged structures? Tập 2 Số 10 - Trang 935-941
Camille G. Wermuth
Compared to carbocyclic drug molecules, pyridazine-containing drugs present
additional interaction possibilities, as illustrated here for the antirhinoviral
agent R 61837.
Synthesis and biological evaluation of coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors Tập 5 Số 5 - Trang 650-654
Xian-Wei Ye, Yi‐Chao Zheng, Ying‐Chao Duan, Mengmeng Wang, Bin Yu, Jingli Ren, Jinlian Ma, En Zhang, Hong‐Min Liu
Design of novel coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1
inhibitors by introducing a coumarin scaffold.
Membranolytic anticancer peptides Tập 7 Số 12 - Trang 2232-2245
Gisela Gabernet, Alex T. Müller, Jan A. Hiss, Gisbert Schneider
Understanding the structure–activity relationships and mechanisms of action of
membranolytic anticancer peptides could help them advance to therapeutic
success.
Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles Tập 7 Số 8 - Trang 1555-1563
Samara Ben B. B. Bahia, Wallace J. Reis, Guilherme A. M. Jardim, Francielly T. Souto, Carlos A. de Simone, Claudia C. Gatto, Rubem F. S. Menna‐Barreto, Solange L. de Castro, Bruno C. Cavalcanti, Cláudia Pessoa, Maria H. Araújo, Eufrânio N. da Silva Júnior
Some of the hybrid compounds exhibited promising trypanocidal and anticancer
activities.
Design, synthesis and evaluation of cinnamic acid ester derivatives as mushroom tyrosinase inhibitors Tập 9 Số 5 - Trang 853-861
Zhaojun Sheng, Si-Yuan Ge, Ximing Xu, Yan Zhang, Panpan Wu, Kun Zhang, Xue-Tao Xu, Chen Li, Deng‐Gao Zhao, Xiaowen Tang
Tyrosinase is a key enzyme in melanin biosynthesis, and is also involved in the
enzymatic browning of plant-derived foods.