Royal Society of Chemistry (RSC)

Compared to carbocyclic drug molecules, pyridazine-containing drugs present additional interaction possibilities, as illustrated here for the antirhinoviral agent R 61837.

Well established as well as recently developed strategies to prevent the fast clearance of peptide drugs from the circulation are reviewed.

Design of novel coumarin–1,2,3-triazole–dithiocarbamate hybrids as potent LSD1 inhibitors by introducing a coumarin scaffold.

Understanding the structure–activity relationships and mechanisms of action of membranolytic anticancer peptides could help them advance to therapeutic success.

Indomethacin belongs to the acetic acid derivative class of non-steroidal anti-inflammatory drugs with diverse pharmacological and biological activities.

Some of the hybrid compounds exhibited promising trypanocidal and anticancer activities.

An original point of view inside the SAR studies to develop new selective COX-2 inhibitors.

Tyrosinase is a key enzyme in melanin biosynthesis, and is also involved in the enzymatic browning of plant-derived foods.