Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles

Royal Society of Chemistry (RSC) - Tập 7 Số 8 - Trang 1555-1563
Samara Ben B. B. Bahia1,2,3,4,5, Wallace J. Reis1,2,3,4,5, Guilherme A. M. Jardim1,2,3,4,5, Francielly T. Souto1,2,3,4,5, Carlos A. de Simone2,6,7,8,9, Claudia C. Gatto10,2,11,12, Rubem F. S. Menna‐Barreto2,13,14,15, Solange L. de Castro2,13,14,15, Bruno C. Cavalcanti2,16,17,18, Cláudia Pessoa2,16,17,18, Maria H. Araújo1,2,3,4,5, Eufrânio N. da Silva Júnior1,2,3,4,5
1Belo Horizonte
2Brazil
3Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil
4Federal University of Minas Gerais
5Institute of Exact Sciences
6Department of Physics and Informatics
7Institute of Physics
8São Carlos
9University of São Paulo
10Brasilia
11Institute of Chemistry, University of Brasilia, Brasilia, DF, Brazil
12University of Brasilia
13FIOCRUZ
14Oswaldo Cruz Institute – FIOCRUZ, Rio de Janeiro (RJ), Brazil
15Rio de Janeiro
16Department of Physiology and Pharmacology,
17Federal University of Ceará
18Fortaleza

Tóm tắt

Some of the hybrid compounds exhibited promising trypanocidal and anticancer activities.

Từ khóa


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