Psychopharmacology

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Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day
Psychopharmacology - Tập 239 - Trang 429-442 - 2021
Simone Rehn, Joel S. Raymond, Robert A. Boakes, Michael T. Bowen
Daily limited access to palatable food or drink at a fixed time is commonly used in rodent models of bingeing. Under these conditions, entrainment may modulate intake patterns. Oxytocin is involved in circadian patterns of intake and, when administered peripherally, reduces sucrose intake. However, oxytocin’s effects on intake under limited-access conditions and its potential interaction with entr...... hiện toàn bộ
Acute tolerance to ethanol using drug discrimination and open-field procedures in rats
Psychopharmacology - Tập 102 - Trang 207-212 - 1990
Arto J. Hiltunen, Torbjörn U. C. Järbe
This study examined the phenomenon of acute tolerance to ethanol (ETOH) using drug discrimination learning (DDL), and open-field (OF) procedures. In DDL, rats were trained to discriminate between ETOH (1.2 g/kg) and saline. Doses of ETOH lower (0.6 and 0.9 g/kg), or higher (1.8 and 2.4 g/kg) than the training dose were tested to examine possible influence of ETOH pretreatment doses on the expressi...... hiện toàn bộ
The effects of d-amphetamine on the inter-response times of rats and guinea-pigs on a modified Sidman discriminated avoidance schedule
Psychopharmacology - Tập 37 - Trang 199-203 - 1974
J. M. Beaton, A. E. LeBlanc, C. D. Webster
Four rats and four guinea-pigs were trained under a modified Sidman discriminated bar-bress avoidance schedule. The guinea-pigs acquired the avoidance response more rapidly than the rats. The Bovet-Gatti d-amphetamine profiles were similar in both species in that there was a significant increase in responding before the stimulus light and click were presented and the inter-response times of effici...... hiện toàn bộ
Cholinergic enhancement of episodic memory in healthy young adults
Psychopharmacology - Tập 182 - Trang 170-179 - 2005
Georg Grön, Matthias Kirstein, Axel Thielscher, Matthias W. Riepe, Manfred Spitzer
Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects. This study evaluated the effects of donepezil, an inhibitor of AchE, on cognitive performance in young and healthy subjects. We used a randomised double-blind parallel group placeb...... hiện toàn bộ
Differential effects of excitotoxic lesions of the amygdala on cocaine-induced conditioned locomotion and conditioned place preference
Psychopharmacology - Tập 113 - Trang 123-130 - 1993
Erin E. Brown, Hans C. Fibiger
The reinforcing properties of cocaine can readily become associated with salient environmental stimuli that acquire secondary reinforcing properties. This type of classical conditioning is of considerable clinical relevance, as intense drug craving can be evoked by the presentation of stimuli previously associated with the effects of cocaine. Given the large body of evidence that implicates the am...... hiện toàn bộ
Motivational effects of drugs: Methods which illustrate some general problems in psychopharmacology
Psychopharmacology - Tập 1 - Trang 169-199 - 1960
Neal E. Miller, Herbert Barry
Evidence for the functional interaction of two central neurotransmitters
Psychopharmacology - Tập 39 - Trang 81-86 - 1974
Barry L. Jacobs
Rats pretreated with pargyline (50 mg/kg) and then given either l-tryptophan (150 mg/kg) or l-Dopa (100 mg/kg) display strikingly similar behavioral syndromes. Especially prominent are tremor, rigidity, lateral head weaving and reciprocal forepaw treading. Because of the overt similarity in these 2 syndromes, it was hypothesized that they might be dependent upon a common neurochemical substrate. T...... hiện toàn bộ
Neuropeptide systems and new treatments for nicotine addiction
Psychopharmacology - Tập 234 - Trang 1419-1437 - 2016
Adriaan W. Bruijnzeel
The mildly euphoric and cognitive enhancing effects of nicotine play a role in the initiation of smoking, while dysphoria and anxiety associated with smoking cessation contribute to relapse. After the acute withdrawal phase, smoking cues, a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and animal studies have shown that neuropeptides play a critical role in nicotine addictio...... hiện toàn bộ
Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms
Psychopharmacology - Tập 237 - Trang 2151-2159 - 2020
Daniel Boloc, Natalia Rodríguez, Teresa Torres, Susana García-Cerro, Mara Parellada, Jeronimo Saiz-Ruiz, Manuel J. Cuesta, Miquel Bernardo, Patricia Gassó, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz
We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks previously created from three pharmacogenomic models (in vitro, animal, and peripheral blood inhumans) were used to, by means of several bioinformati...... hiện toàn bộ
Spatial frequency processing and its modulation by emotional content in severe alcohol use disorder
Psychopharmacology - Tập 239 Số 8 - Trang 2647-2657 - 2022
Coralie Creupelandt, Pierre Maurage, Bruno R. Bocanegra, Sébastien Szaffarczyk, Philippe de Timary, Jory Deleuze, Carine Lambot, Fabien D’Hondt
Tổng số: 12,149   
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