Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of dayPsychopharmacology - Tập 239 - Trang 429-442 - 2021
Simone Rehn, Joel S. Raymond, Robert A. Boakes, Michael T. Bowen
Daily limited access to palatable food or drink at a fixed time is commonly used in rodent models of bingeing. Under these conditions, entrainment may modulate intake patterns. Oxytocin is involved in circadian patterns of intake and, when administered peripherally, reduces sucrose intake. However, oxytocin’s effects on intake under limited-access conditions and its potential interaction with entr...... hiện toàn bộ
Acute tolerance to ethanol using drug discrimination and open-field procedures in ratsPsychopharmacology - Tập 102 - Trang 207-212 - 1990
Arto J. Hiltunen, Torbjörn U. C. Järbe
This study examined the phenomenon of acute tolerance to ethanol (ETOH) using drug discrimination learning (DDL), and open-field (OF) procedures. In DDL, rats were trained to discriminate between ETOH (1.2 g/kg) and saline. Doses of ETOH lower (0.6 and 0.9 g/kg), or higher (1.8 and 2.4 g/kg) than the training dose were tested to examine possible influence of ETOH pretreatment doses on the expressi...... hiện toàn bộ
Cholinergic enhancement of episodic memory in healthy young adultsPsychopharmacology - Tập 182 - Trang 170-179 - 2005
Georg Grön, Matthias Kirstein, Axel Thielscher, Matthias W. Riepe, Manfred Spitzer
Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects. This study evaluated the effects of donepezil, an inhibitor of AchE, on cognitive performance in young and healthy subjects. We used a randomised double-blind parallel group placeb...... hiện toàn bộ
Evidence for the functional interaction of two central neurotransmittersPsychopharmacology - Tập 39 - Trang 81-86 - 1974
Barry L. Jacobs
Rats pretreated with pargyline (50 mg/kg) and then given either l-tryptophan (150 mg/kg) or l-Dopa (100 mg/kg) display strikingly similar behavioral syndromes. Especially prominent are tremor, rigidity, lateral head weaving and reciprocal forepaw treading. Because of the overt similarity in these 2 syndromes, it was hypothesized that they might be dependent upon a common neurochemical substrate. T...... hiện toàn bộ
Neuropeptide systems and new treatments for nicotine addictionPsychopharmacology - Tập 234 - Trang 1419-1437 - 2016
Adriaan W. Bruijnzeel
The mildly euphoric and cognitive enhancing effects of nicotine play a role in the initiation of smoking, while dysphoria and anxiety associated with smoking cessation contribute to relapse. After the acute withdrawal phase, smoking cues, a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and animal studies have shown that neuropeptides play a critical role in nicotine addictio...... hiện toàn bộ
Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptomsPsychopharmacology - Tập 237 - Trang 2151-2159 - 2020
Daniel Boloc, Natalia Rodríguez, Teresa Torres, Susana García-Cerro, Mara Parellada, Jeronimo Saiz-Ruiz, Manuel J. Cuesta, Miquel Bernardo, Patricia Gassó, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz
We explore the transcription factors involved in the molecular mechanism of antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to identify new candidate genes for pharmacogenetic studies. Protein-protein interaction (PPI) networks previously created from three pharmacogenomic models (in vitro, animal, and peripheral blood inhumans) were used to, by means of several bioinformati...... hiện toàn bộ