Psychopharmacology
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Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day
Psychopharmacology - Tập 239 - Trang 429-442 - 2021
Daily limited access to palatable food or drink at a fixed time is commonly used
in rodent models of bingeing. Under these conditions, entrainment may modulate
intake patterns. Oxytocin is involved in circadian patterns of intake and, when
administered peripherally, reduces sucrose intake. However, oxytocin’s effects
on intake under limited-access conditions and its potential interaction with
entr...
Acute tolerance to ethanol using drug discrimination and open-field procedures in rats
Psychopharmacology - Tập 102 - Trang 207-212 - 1990
This study examined the phenomenon of acute tolerance to ethanol (ETOH) using
drug discrimination learning (DDL), and open-field (OF) procedures. In DDL, rats
were trained to discriminate between ETOH (1.2 g/kg) and saline. Doses of ETOH
lower (0.6 and 0.9 g/kg), or higher (1.8 and 2.4 g/kg) than the training dose
were tested to examine possible influence of ETOH pretreatment doses on the
expressi...
The effects of d-amphetamine on the inter-response times of rats and guinea-pigs on a modified Sidman discriminated avoidance schedule
Psychopharmacology - Tập 37 - Trang 199-203 - 1974
Four rats and four guinea-pigs were trained under a modified Sidman
discriminated bar-bress avoidance schedule. The guinea-pigs acquired the
avoidance response more rapidly than the rats. The Bovet-Gatti d-amphetamine
profiles were similar in both species in that there was a significant increase
in responding before the stimulus light and click were presented and the
inter-response times of effici...
Cholinergic enhancement of episodic memory in healthy young adults
Psychopharmacology - Tập 182 - Trang 170-179 - 2005
Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of
Alzheimer's disease. However, only few systematic data exist on the effects of
cholinergic treatment on cognitive functions in normal subjects. This study
evaluated the effects of donepezil, an inhibitor of AchE, on cognitive
performance in young and healthy subjects. We used a randomised double-blind
parallel group placeb...
Differential effects of excitotoxic lesions of the amygdala on cocaine-induced conditioned locomotion and conditioned place preference
Psychopharmacology - Tập 113 - Trang 123-130 - 1993
The reinforcing properties of cocaine can readily become associated with salient
environmental stimuli that acquire secondary reinforcing properties. This type
of classical conditioning is of considerable clinical relevance, as intense drug
craving can be evoked by the presentation of stimuli previously associated with
the effects of cocaine. Given the large body of evidence that implicates the
am...
Evidence for the functional interaction of two central neurotransmitters
Psychopharmacology - Tập 39 - Trang 81-86 - 1974
Rats pretreated with pargyline (50 mg/kg) and then given either l-tryptophan
(150 mg/kg) or l-Dopa (100 mg/kg) display strikingly similar behavioral
syndromes. Especially prominent are tremor, rigidity, lateral head weaving and
reciprocal forepaw treading. Because of the overt similarity in these 2
syndromes, it was hypothesized that they might be dependent upon a common
neurochemical substrate. T...
Motivational effects of drugs: Methods which illustrate some general problems in psychopharmacology
Psychopharmacology - Tập 1 - Trang 169-199 - 1960
Neuropeptide systems and new treatments for nicotine addiction
Psychopharmacology - Tập 234 - Trang 1419-1437 - 2016
The mildly euphoric and cognitive enhancing effects of nicotine play a role in
the initiation of smoking, while dysphoria and anxiety associated with smoking
cessation contribute to relapse. After the acute withdrawal phase, smoking cues,
a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and
animal studies have shown that neuropeptides play a critical role in nicotine
addictio...
Identifying key transcription factors for pharmacogenetic studies of antipsychotics induced extrapyramidal symptoms
Psychopharmacology - Tập 237 - Trang 2151-2159 - 2020
We explore the transcription factors involved in the molecular mechanism of
antipsychotic (AP)-induced acute extrapyramidalsymptoms (EPS) in order to
identify new candidate genes for pharmacogenetic studies. Protein-protein
interaction (PPI) networks previously created from three pharmacogenomic models
(in vitro, animal, and peripheral blood inhumans) were used to, by means of
several bioinformati...
Spatial frequency processing and its modulation by emotional content in severe alcohol use disorder
Psychopharmacology - Tập 239 Số 8 - Trang 2647-2657 - 2022
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