Psychopharmacology
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Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day
Psychopharmacology - Tập 239 - Trang 429-442 - 2021
Daily limited access to palatable food or drink at a fixed time is commonly used in rodent models of bingeing. Under these conditions, entrainment may modulate intake patterns. Oxytocin is involved in circadian patterns of intake and, when administered peripherally, reduces sucrose intake. However, oxytocin’s effects on intake under limited-access conditions and its potential interaction with entr......
Motivational effects of drugs: Methods which illustrate some general problems in psychopharmacology
Psychopharmacology - Tập 1 - Trang 169-199 - 1960
Neuropeptide systems and new treatments for nicotine addiction
Psychopharmacology - Tập 234 - Trang 1419-1437 - 2016
The mildly euphoric and cognitive enhancing effects of nicotine play a role in the initiation of smoking, while dysphoria and anxiety associated with smoking cessation contribute to relapse. After the acute withdrawal phase, smoking cues, a few cigarettes (i.e., lapse), and stressors can cause relapse. Human and animal studies have shown that neuropeptides play a critical role in nicotine addictio......
Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test
Psychopharmacology - Tập 205 - Trang 475-487 - 2009
Cannabinoid compounds are known to regulate feeding behavior by modulating the hedonic and/or the incentive properties of food. The aim of this work was to determine the involvement of the cannabinoid system in food reinforcement associated with a conflict situation generated by stress. Mice were trained on a fixed ratio 1 schedule of reinforcement to obtain standard, chocolate-flavored or fat-enr......
Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment
Psychopharmacology - Tập 108 - Trang 263-270 - 1992
The effects of ritanserin, a 5-hydroxytryptamine-2 (5-HT2) receptor antagonist, and chlordiazepoxide, a benzodiazepine agonist, on sleep-wakefulness disturbances in rats after acute administration of cocaine and after discontinuation of chronic cocaine treatment were examined. Intraperitoneal (IP) injection of chlordiazepoxide (10 mg/kg) but not ritanserin (0.63 mg/kg) prevented the increase of wa......
Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys
Psychopharmacology - Tập 145 - Trang 205-212 - 1999
Rationale and Objectives: The present study was designed to assess possible abuse-related effects of the endogenous neuroactive steroid pregnanolone (3α-hydroxy-5β-pregnan-20-one) and the orally bioavailable, water-soluble neuroactive steroid pro-drug Co 8-7071 (3α,21-dihydroxy-3β-trifluoromethyl-5β-pregnan-20-one, 21-hemisuccinate). Methods: Four rhesus monkeys were pre......
Does haloperidol block methylphenidate?
Psychopharmacology - Tập 126 Số 1 - Trang 70-74 - 1996
The effect of methylphenidate preceded by a moderate dose of haloperidol on reaction times over the duration of a continuous performance test (CPT) was investigated in ten male children, with a DSM-III diagnosis of attention deficit disorder with hyperactivity disorder (ADDH). Using a within-subject double-blind design, the effects of methylphenidate preceded by haloperidol on reaction time during......
The process of learning in rats undergoing prolonged treatment with psychotropic agents
Psychopharmacology - Tập 18 - Trang 144-153 - 1970
The effect of amphetamine and chlorpromazine on the process of learning and the change in performance of acquired skills in rats was studied. Maze tests were camed out for 23 days and conditioned reflex tests for 37 days. Animals received 0.5 mg/kg/day of amphetamine or 0.5 mg/kg/day of chlorpromazine added to the drinking water. Further groups received daily intraperitoneal injections of 0.25 mg/......
Gender differences in the prevalence, risk and clinical correlates of tardive dyskinesia in Chinese schizophrenia
Psychopharmacology - Tập 205 Số 4 - Trang 647-654 - 2009
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