Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day
Tóm tắt
Daily limited access to palatable food or drink at a fixed time is commonly used in rodent models of bingeing. Under these conditions, entrainment may modulate intake patterns. Oxytocin is involved in circadian patterns of intake and, when administered peripherally, reduces sucrose intake. However, oxytocin’s effects on intake under limited-access conditions and its potential interaction with entrainment have not been explored. This study examined the role of entrainment on intake patterns, oxytocin’s effects on sucrose intakes and locomotor activity and whether oxytocin’s effects were mediated by its actions at the oxytocin receptor. Sated rats received daily 1-h access to 10% sucrose solution either at a fixed or varied time of day. Rats received intraperitoneal oxytocin (0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg) prior to sucrose access, and spontaneous locomotor activity was assessed in an open-field test. Rats were then pre-treated with an oxytocin receptor antagonist, L368,899, prior to oxytocin before sucrose access. Intake patterns did not differ between fixed- or varied-time presentations; rats consumed more sucrose solution in the middle as opposed to the early-dark phase. Oxytocin dose-dependently reduced sucrose intakes, but also reduced locomotor activity. There was some evidence of partial blockade of oxytocin-induced sucrose intake reductions by L368,899, but the results were unclear. Time of day and oxytocin impact sucrose solution intake under daily limited access in rats and the sedative-like effects of oxytocin should be considered in future studies on oxytocin and food intake.
Tài liệu tham khảo
Abe H, Rusak B (1992) Anticipatory activity and entrainment of circadian rhythms in Syrian hamsters exposed to restricted palatable diets. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 263(1 Pt 2):R116-124. https://doi.org/10.1152/ajpregu.1992.263.1.R116
Agabio R, Farci AMG, Curreli O, Deidda R, Mercuro S, Naitana R, . . . Melis MR (2016). Oxytocin nasal spray in the treatment of binge eating disorder and obesity: a pilot, randomized, double blind trial
Angeles-Castellanos M, Salgado-Delgado R, Rodriguez K, Buijs R, Escobar C (2008) Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward. Neuroscience 155(1):297–307
Arletti R, Benelli A, Bertolini A (1990) Oxytocin inhibits food and fluid intake in rats. Physiology & Behavior, 48(6):825–830
Bake T, Morgan D, Mercer JG (2014a) Feeding and metabolic consequences of scheduled consumption of large, binge-type meals of high fat diet in the Sprague-Dawley rat. Physiology & Behavior, 128:70–79
Bake T, Murphy M, Morgan DGA, Mercer JG (2014b) Large, binge-type meals of high fat diet change feeding behaviour and entrain food anticipatory activity in mice. Appetite 77:62–73
Benelli A, Bertolini A, Arletti R (1991) Oxytocin-induced inhibition of feeding and drinking: no sexual dimorphism in rats. Neuropeptides 20(1):57–62
Berner LA, Avena NM, Hoebel BG (2008) Bingeing, self-restriction, and increased body weight in rats with limited access to a sweet-fat diet. Obesity 16(9):1998–2002
Berridge KC, Robinson TE (2016) Liking, wanting, and the incentive-sensitization theory of addiction. American Psychologist, 71(8):670
Boakes RA, & Wu J (2020). Time-of-day affects the amount rats run during daily sessions in activity wheels. Learning & Behavior, 1–8
Bolles RC, Moot SA (1973) The rat’s anticipation of two meals a day. Journal of Comparative and Physiological Psychology, 83(3):510
Boulos Z, Rosenwasser AM, Terman M (1980) Feeding schedules and the circadian organization of behavior in the rat. Behavioral Brain Research, 1(1):39–65
Bowen MT, McGregor IS (2014) Oxytocin and vasopressin modulate the social response to threat: a preclinical study. International Journal of Neuropsychopharmacology, 17(10):1621–1633
Bowen MT, Neumann ID (2017) Rebalancing the addicted brain: oxytocin interference with the neural substrates of addiction. Trends in Neurosciences, 40(12):691–708
Bowen MT (2019). Does peripherally administered oxytocin enter the brain? Compelling new evidence in a long-running debate. Pharmacological Research 146:104325. doi: 10.1016/j.phrs.2019.104325.
Brennan K, Roberts D, Anisman H, Merali Z (2001) Individual differences in sucrose consumption in the rat: motivational and neurochemical correlates of hedonia. Psychopharmacology 157(3):269–276
Caba M, Huerta C, Meza E, Hernández M, & Rovirosa-Hernández MJ (2020). Oxytocinergic cells of the hypothalamic paraventricular nucleus are involved in food entrainment. Frontiers in Neuroscience, 14.
Edmonds SC, Adler NT (1977) Food and light as entrainers of circadian running activity in the rat. Physiology & Behavior, 18(5):915–919
Everett NA, McGregor IS, Baracz SJ, Cornish JL (2018) The role of the vasopressin V1A receptor in oxytocin modulation of methamphetamine primed reinstatement. Neuropharmacology 133:1–11
Everett NA, Carey HA, Cornish JL, Baracz SJ (2020) Sign tracking predicts cue-induced but not drug-primed reinstatement to methamphetamine seeking in rats: effects of oxytocin treatment. Psychopharmacology 34(11):1271–1279
Furlong TM, Jayaweera HK, Balleine BW, Corbit LH (2014) Binge-like consumption of a palatable food accelerates habitual control of behavior and is dependent on activation of the dorsolateral striatum. Journal of Neuroscience 34(14):5012–5022
Gulati K, Ray A, Sharma KK (1991) Effects of acute and chronic morphine on food intake in rats: modulation by oxytocin and vasopressin. Pharmacology Biochemistry and Behavior 40(1):27–32
Hara E, Saito M (1989) Diurnal change in digestion and absorption of sucrose in vivo in rats. Journal of nutritional science and vitaminology, 35(6):667–671
Hardaway JA, Jensen J, Kim M, Mazzone CM, Sugam JA, Diberto JF, . . . Kash TL (2016). Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behavioural Brain Research, 307, 25-34
Herisson F, Waas J, Fredriksson R, Schiöth HB, Levine AS, & Olszewski P (2016). Oxytocin acting in the nucleus accumbens core decreases food intake. Journal of Neuroendocrinology, 28(4)
Ho JM, Anekonda VT, Thompson BW, Zhu M, Curry RW, Hwang BH, . . . Appleyard SM (2014). Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology, 155(8), 2845-2857
Inouye S-I, Kawamura H (1979) Persistence of circadian rhythmicity in a mammalian hypothalamic “island” containing the suprachiasmatic nucleus. Proc Natl Acad Sci 76(11):5962–5966
Kersten A, Strubbe JH, Spiteri NJ (1980) Meal patterning of rats with changes in day length and food availability. Physiology & Behavior 25(6):953–958
Kinzig KP, Hargrave SL, Honors MA (2008) Binge-type eating attenuates corticosterone and hypophagic responses to restraint stress. Physiology & Behavior, 95(1):108–113
Klenerova V, Krejci I, Sida P, Hlinak Z, Hynie S (2009) Oxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists. Neuroendocrinology Letters, 30:335–342
Klockars A, Brunton C, Li L, Levine AS, Olszewski PK (2017) Intravenous administration of oxytocin in rats acutely decreases deprivation-induced chow intake, but it fails to affect consumption of palatable solutions. Peptides 93:13–19
Kosheleff AR, Araki J, Hsueh J, Le A, Quizon K, Ostlund SB, . . . Murphy NP (2018). Pattern of access determines influence of junk food diet on cue sensitivity and palatability. Appetite, 123, 135-145
Lee S-Y, Park S-H, Chung C, Kim JJ, Choi S-Y, Han J-S (2015) Oxytocin protects hippocampal memory and plasticity from uncontrollable stress. Scientific Reports, 5:18540
Leslie M, Silva P, Paloyelis Y, Blevins J, Treasure J (2018) A systematic review and quantitative meta-analysis of the effects of oxytocin on feeding. Journal of Neuroendocrinology, 30(8):e12584. https://doi.org/10.1111/jne.12584
Leslie M, Leppanen J, Paloyelis Y, Treasure J (2020) A pilot study investigating the influence of oxytocin on attentional bias to food images in women with bulimia nervosa or binge eating disorder. Journal of Neuroendocrinology 32(5):e12843
Lin C-H, Tsai C-C, Chen T-H, Chang C-P, Yang H-H (2019) Oxytocin maintains lung histological and functional integrity to confer protection in heat stroke. Scientific Reports, 9(1):1–10
Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, . . . Shimomura K (2014). Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS letters, 588(23), 4404-4412
Manning M, Misicka A, Olma A, Bankowski K, Stoev S, Chini B, . . . Guillon G (2012). Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics. Journal of Neuroendocrinology, 24(4), 609-628
Mendoza J, Angeles-Castellanos M, Escobar C (2005) Entrainment by a palatable meal induces food-anticipatory activity and c-Fos expression in reward-related areas of the brain. Neuroscience 133(1):293–303
Mens WB, Witter A, Greidanus TBVW (1983) Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Research, 262(1):143–149
Mistlberger RE (1993) Effects of scheduled food and water access on circadian rhythms of hamsters in constant light, dark, and light: dark. Physiology & Behavior, 53(3):509–516
Mistlberger RE (1994) Circadian food-anticipatory activity: formal models and physiological mechanisms. Neuroscience & Biobehavioral Reviews, 18(2):171–195
Mistlberger RE (2009) Food anticipatory circadian rhythms: concepts and methods. European Journal of Neuroscience, 30(9):1718–1729
Mistlberger RE, Rusak B (1987) Palatable daily meals entrain anticipatory activity rhythms in free-feeding rats: dependence on meal size and nutrient content. Physiology & Behavior 41(3):219–226
Mullis K, Kay K, Williams DL (2013) Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Research, 1513:85–91
Muñoz-Escobar G, Guerrero-Vargas NN, Escobar C (2019) Random access to palatable food stimulates similar addiction-like responses as a fixed schedule, but only a fixed schedule elicits anticipatory activation. Scientific Reports, 9(1):1–13
Neumann ID, Maloumby R, Beiderbeck DI, Lukas M, Landgraf R (2013) Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice. Psychoneuroendocrinology 38(10):1985–1993
Noble EE, Billington CJ, Kotz CM, Wang C (2014) Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307(6):R737–R745
Olszewski PK, Shaw TJ, Grace MK, Höglund CE, Fredriksson R, Schiöth HB, Levine AS (2009) Complexity of neural mechanisms underlying overconsumption of sugar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY. Peptides 30(2):226–233
Olszewski PK, Klockars A, Olszewska AM, Fredriksson R, Schiöth HB, Levine AS (2010) Molecular, immunohistochemical, and pharmacological evidence of oxytocin’s role as inhibitor of carbohydrate but not fat intake. Endocrinology 151(10):4736–4744. https://doi.org/10.1210/en.2010-0151
Olszewski PK, Allen K, Levine AS (2015) Effect of oxytocin receptor blockade on appetite for sugar is modified by social context. Appetite 86:81–87
Ong ZY, Alhadeff AL, Grill HJ (2015) Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308(9):R800–R806
Ramos L, Hicks C, Kevin R, Caminer A, Narlawar R, Kassiou M, McGregor IS (2013) Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3, 4-methylenedioxymethamphetamine in rats: involvement of the V1 A receptor. Neuropsychopharmacology 38(11):2249–2259
Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC (2005) Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiology & Behavior 84(1):53–63
Richter CP (1922). A behavioristic study of the activity of the rat. Comparative Psychology Monographs
Romano A, Friuli M, Cifani C, & Gaetani S (2020). Oxytocin in the neural control of eating: at the crossroad between homeostatic and non-homeostatic signals. Neuropharmacology, 108082
Sabatier N, Leng G, & Menzies J (2013). Oxytocin, feeding, and satiety. Frontiers in Endocrinology, 4(35). doi:https://doi.org/10.3389/fendo.2013.00035
Saito R, Sonoda S, Ueno H, Motojima Y, Yoshimura M, Maruyama T, . . . Kusuhara K (2017). Involvement of central nesfatin-1 neurons on oxytocin-induced feeding suppression in rats. Neuroscience Letters, 655, 54-60
Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V, . . . Rubino T (2011). Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biological psychiatry, 69(9), 875-882
Sclafani A, Rinaman L, Vollmer RR, Amico JA (2007) Oxytocin knockout mice demonstrate enhanced intake of sweet and nonsweet carbohydrate solutions. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 292(5):R1828–R1833
Siegal PS (1961) Food intake in the rat in relation to the dark-light cycle. Journal of Comparative and Physiological Psychology 54(3):294
Smith AS, Korgan AC, Young WS (2019) Oxytocin delivered nasally or intraperitoneally reaches the brain and plasma of normal and oxytocin knockout mice. Pharmacological Research 146:104324
Spiteri NJ (1982) Circadian patterning of feeding, drinking and activity during diurnal food access in rats. Physiology & Behavior 28(1):139–147
Tan O, Musullulu H, Raymond JS, Wilson B, Langguth M, Bowen MT (2019) Oxytocin and vasopressin inhibit hyper-aggressive behaviour in socially isolated mice. Neuropharmacology, 156:107573
Terman M, Terman JS (1975) Control of the rat’s circadian self-stimulation rhythm by light-dark cycles. Physiology & Behavior, 14(6):781–789
Thompson KL, Vincent SH, Miller RR, Colletti AE, Alvaro RF, Wallace MA, . . . Chiu S-HL (1997). Pharmacokinetics and disposition of the oxytocin receptor antagonist L-368,899 in rats and dogs. Drug metabolism and disposition, 25(10), 1113-1118
Tõnissaar M, Herm L, Rinken A, Harro J (2006) Individual differences in sucrose intake and preference in the rat: circadian variation and association with dopamine D2 receptor function in striatum and nucleus accumbens. Neuroscience Letters, 403(1–2):119–124
Zhang G, Cai D (2011) Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. American Journal of Physiology-Endocrinology and Metabolism 301(5):E1004–E1012
Zhou L, Ghee SM, See RE, Reichel CM (2015) Oxytocin differentially affects sucrose taking and seeking in male and female rats. Behavioural Brain Research, 283:184–190