The process of learning in rats undergoing prolonged treatment with psychotropic agents
Tóm tắt
The effect of amphetamine and chlorpromazine on the process of learning and the change in performance of acquired skills in rats was studied. Maze tests were camed out for 23 days and conditioned reflex tests for 37 days. Animals received 0.5 mg/kg/day of amphetamine or 0.5 mg/kg/day of chlorpromazine added to the drinking water. Further groups received daily intraperitoneal injections of 0.25 mg/kg of amphetamine or 4 mg/kg of chlorpromazine. The learning index deteriorated initially by oral administration of amphetamine, but subsequently improved, whereas intraperitoneal treatment caused a slight deterioration. Both agents interfered with previously acquired conditioned responses. The frequency of pseudopositive responses was considerably higher following administration of amphetamine, but was unalterated by chlorpromazine.
Tài liệu tham khảo
Chance, M. R. A., Silverman, A. P.: The structure of social behaviour and drug action. In: Animal behaviour and drug action, p. 65–79. H. Steinberg ed. London: Churchill 1964.
Dési, I., Farkas, I., Sós, J., Balogh, A.: Neurophysiological effects of glutamic acid ethylester. Acta physiol. Acad. Sci. hung. 32, 323–335 (1967).
Glanzer, M.: Curiosity, exploratory drive and stimulus satiation. Psychol. Bull. 55, 302–315 (1958).
Grandjean, E., Bättig, K.: Die Wirkung verschiedener Psychopharmaka auf die spontane Alternation der Ratte. Helv. physiol. pharmacol. Acta 20, 373–381 (1962).
Hajtman, B.: Introduction into the mathematical statistics for psychologist, p. 491. Budapest (Hung.): Akad. Kiad. 1968.
Jacobsen, E.: The comparative pharmacology of some psychotropic drugs. Bull. Wld Hlth Org. 21, 411–493 (1959).
Key, B. J., Bradley, P. B.: The effects of drugs on conditioning and habituation to arousal stimuli in animals. Psychopharmacologia (Berl.) 1, 450–462 (1960).
Lát, J.: The spontaneous exploratory reactions as a tool for psychopharmacological studies. In: Proc. 2nd Int. Pharmacol. Meeting, Prague, pp. 47–66. Prague: Czechoslovak Med. Press 1956.
—, Gollová, E.: Drug induced increase of central nervous excitability and the emergence of spontaneous stereotyped reactions. Activ. nerv. sup. (Praha) 6, 200–201 (1964).