Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test

Psychopharmacology - Tập 205 - Trang 475-487 - 2009
Maria Flavia Barbano1,2, Anna Castañé1,3, Elena Martín-García1, Rafael Maldonado1
1Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB, Barcelona, Spain
2Instituto de Investigaciones Biotecnológicas, Universidad de General San Martín, INTI, San Martín, Argentina
3Department of Neurochemistry and Neuropharmacology, Institut d’Investigacions Biomèdiques de Barcelona (CSIC), IDIBAPS, Barcelona, Spain

Tóm tắt

Cannabinoid compounds are known to regulate feeding behavior by modulating the hedonic and/or the incentive properties of food. The aim of this work was to determine the involvement of the cannabinoid system in food reinforcement associated with a conflict situation generated by stress. Mice were trained on a fixed ratio 1 schedule of reinforcement to obtain standard, chocolate-flavored or fat-enriched pellets. Once the acquisition criteria were achieved, the reinforced lever press was paired with foot-shock exposure, and the effects of Δ9-tetrahydrocannabinol (THC; 1 mg/kg) were evaluated in this conflict paradigm. THC did not modify the operant response in mice trained with standard pellets. In contrast, THC improved the instrumental performance of mice trained with chocolate-flavored and fat-enriched pellets. However, the cannabinoid agonist did not fully restore the baseline responses obtained previous to foot-shock delivery. THC ameliorated the performance to obtain high palatable food in this conflict test in both food-restricted and sated mice. The effects of THC on food reinforcement seem to be long-lasting since mice previously treated with this compound showed a better recovery of the instrumental behavior after foot-shock exposure. These findings reveal that the cannabinoid system is involved in the regulation of goal-directed responses towards high palatable and high caloric food under stressful situations.

Tài liệu tham khảo

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