Does haloperidol block methylphenidate?
Tóm tắt
The effect of methylphenidate preceded by a moderate dose of haloperidol on reaction times over the duration of a continuous performance test (CPT) was investigated in ten male children, with a DSM-III diagnosis of attention deficit disorder with hyperactivity disorder (ADDH). Using a within-subject double-blind design, the effects of methylphenidate preceded by haloperidol on reaction time during the first and second blocks of CPT test were compared. Methylphenidate maintained a significantly improved reaction time in the second block of the CPT test. When methylphenidate, preceded by placebo, was preceded by haloperidol this effect was not observed, suggesting opposing effects on attentional systems by methylphenidate versus haloperidol. The study is the first to examine the “blocking” effect of haloperidol over the course of a CPT. The results suggest that dopamine systems are involved in the maintenance of the CPT response, and support an “incentive motivation” theory of sustained attention.
Tài liệu tham khảo
citation_title=Attention deficit hyperactivity disorder. A handbook for diagnosis and treatment; citation_publication_date=1990; citation_id=CR1; citation_author=RA Barkley; citation_publisher=Guilford Press
citation_journal_title=Pharmacol Biochem Behav; citation_title=Reward system depression following chronic amphetamine: antagonism by haloperidol; citation_author=RJ Barrett, DK White; citation_volume=13; citation_publication_date=1980; citation_pages=555-559; citation_id=CR2
citation_title=Status and prestige in Australia; citation_publication_date=1969; citation_id=CR3; citation_author=A Congalton; citation_publisher=Cheshire
citation_journal_title=J Child Psychol Psychiatry; citation_author=LMJ Sonneville, C Njiokiktjien, RC Hilhorst; citation_volume=32; citation_issue=2; citation_publication_date=1991; citation_pages=285-295; citation_id=CR4
citation_title=Attention and cognitive problems; citation_inbook_title=Developmental neuropsychiatry; citation_publication_date=1993; citation_id=CR5; citation_author=VI Douglas; citation_publisher=Guilford Press
citation_journal_title=J Learn Disabil; citation_title=Cognitive event-related potentials in attention deficit disorder; citation_author=R Klorman; citation_volume=24; citation_issue=3; citation_publication_date=1991; citation_pages=130-140; citation_id=CR6
citation_journal_title=Psychophysiology; citation_title=Effects of methylphenidate on hyperactive children's evoked responses during passive and active attention; citation_author=R Klorman, LF Salzman, HL Pass, AD Borgstedt, KG Dainer; citation_volume=16; citation_issue=1; citation_publication_date=1979; citation_pages=23-29; citation_id=CR7
citation_journal_title=J Child Psychol Psychiatry; citation_title=The development of sustained attention (vigilance) and inhibition in children: some normative data; citation_author=F Levy; citation_volume=21; citation_publication_date=1980; citation_pages=77-84; citation_id=CR8
citation_journal_title=Aust NZ J Psychiatry; citation_title=The dopamine theory of attention deficit hyperactivity disorder (ADHD); citation_author=F Levy; citation_volume=25; citation_publication_date=1991; citation_pages=277-283; citation_id=CR9
citation_journal_title=J Am Acad Child Adoles Psychiatry; citation_title=The action of stimulant medication in attention deficit disorder with hyperactivity: dopaminergic, noradrenergic, or both?; citation_author=F Levy, G Hobbes; citation_volume=276; citation_publication_date=1988; citation_pages=802-805; citation_id=CR10
citation_journal_title=J Am Acad Child Adoles Psychiatry; citation_title=The diagnosis of attention deficit disorder (hyperkinesis) in children; citation_author=F Levy, G Hobbes; citation_volume=20; citation_publication_date=1981; citation_pages=376-384; citation_id=CR11
citation_journal_title=Psychophysiology; citation_title=Normalizing effects of methylphenidate on hyperactive children's vigilance performance and evoked potentials; citation_author=RL Michel, R Klorman, LF Salzman, AD Borgstedt, KB Dainer; citation_volume=18; citation_publication_date=1981; citation_pages=665-677; citation_id=CR12
citation_journal_title=Prog Neurobiol; citation_title=From motivation to action: functional interface between the limbic system and the motor system; citation_author=GJ Mogenson, DL Jones, CY Yim; citation_volume=14; citation_publication_date=1980; citation_pages=69-97; citation_id=CR13
citation_journal_title=Neuropharmacology; citation_title=“Paradoxical” effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology; citation_author=TW Robbins, BJ Sahakian; citation_volume=18; citation_publication_date=1979; citation_pages=931-950; citation_id=CR14
citation_title=Behavioural effects of psychomotor stimulant drugs clinical and neuropsychological implications; citation_inbook_title=Stimulants: clinical behavioural and neurochyemical perspectives; citation_publication_date=1983; citation_pages=301-338; citation_id=CR15; citation_author=TW Robbins; citation_author=BJ Sahakian; citation_publisher=Raven Press
citation_title=Drug treatment of children with behaviour problems; citation_inbook_title=Review of child development research vol. 4; citation_publication_date=1975; citation_id=CR16; citation_author=LA Sroufe; citation_publisher=University of Chicago Press
citation_journal_title=Psychophysiology; citation_title=Effects of methylphenidate on young adults' performance and event-related potentials in a vigilance and paired-associates learning test; citation_author=J Straus, JL Lewis, R Klorman, LJ Peloquin, RA Perlmutter, LF Salzman; citation_volume=21; citation_publication_date=1984; citation_pages=609-621; citation_id=CR17
citation_journal_title=J Child Psychol Psychiatry; citation_title=Attention in hyperactive children and the effect of methylphenidate (Ritalin); citation_author=DH Sykes, VI Douglas, G Weiss, K Minde; citation_volume=12; citation_publication_date=1971; citation_pages=129-139; citation_id=CR18
citation_title=Motivational systems; citation_publication_date=1984; citation_id=CR19; citation_author=F Toates; citation_publisher=Cambridge University Press
citation_journal_title=J Abnorm Child Psychol; citation_title=Controlled processing and vigilance in hyperactivity: time will tell; citation_author=J Meere, J Sergeant; citation_volume=16; citation_issue=6; citation_publication_date=1988; citation_pages=641-655; citation_id=CR20
citation_journal_title=Arch Gen Psychiatry; citation_title=Methylphenidate and haloperidol in children; citation_author=J Werry, MG Amon; citation_volume=32; citation_publication_date=1975; citation_pages=790-795; citation_id=CR21
citation_title=Depression: a psychological synthesis; citation_publication_date=1985; citation_id=CR22; citation_author=P Willner; citation_publisher=Wiley
citation_journal_title=J Am Acad Child Adoles Psychiatry; citation_title=Neurobiology of attention deficit disorder with hyperactivity: where have we come in 50 years?; citation_author=AJ Zametkin, JL Rapoport; citation_volume=26; citation_publication_date=1987; citation_pages=670-686; citation_id=CR23