Pharmaceuticals
SCOPUS (2004,2009-2023)SCIE-ISI
1424-8247
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
Molecular MedicineDrug DiscoveryPharmaceutical Science
Các bài báo tiêu biểu
Cobalt Complexes as Antiviral and Antibacterial AgentsMetal ion complexes are playing an increasing role in the development of antimicrobials. We review here the antimicrobial properties of cobalt coordination complexes in oxidation state 3+. In addition to reviewing the cobalt complexes containing polydentate donor ligands, we also focus on the antimicrobial activity of the homoleptic [Co(NH3)6]3+ ion.
Tập 3 Số 6 - Trang 1711-1728
Antimicrobial Peptides from FishAntimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species... ... hiện toàn bộ
Tập 7 Số 3 - Trang 265-310
A Review of Ten Years of the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2002 to 2011Surveillance of antimicrobial agent resistance provides important information to guide microbiologists and infectious disease specialists understanding of the control and the spread of resistance mechanisms within the local environment. Continued monitoring of antimicrobial resistance patterns in the community and in local hospital environments is essential to guide effective empiric thera... ... hiện toàn bộ
Tập 6 Số 11 - Trang 1335-1346
Colchicine-Binding Site Inhibitors from Chemistry to Clinic: A ReviewIt is over 50 years since the discovery of microtubules, and they have become one of the most important drug targets for anti-cancer therapies. Microtubules are predominantly composed of the protein tubulin, which contains a number of different binding sites for small-molecule drugs. There is continued interest in drug development for compounds targeting the colchicine-binding site of tubu... ... hiện toàn bộ
Tập 13 Số 1 - Trang 8
Inflammation and Neuro-Immune Dysregulations in Autism Spectrum DisordersAutism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dysfunction. Several cell types are enrolled to trigger and sustain these processes. Neuro-inf... ... hiện toàn bộ
Tập 11 Số 2 - Trang 56
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and ChallengesRNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems. Inspired by the immense progress with nano... ... hiện toàn bộ
Tập 6 Số 1 - Trang 85-107
Lactoferrin from Milk: Nutraceutical and Pharmacological PropertiesLactoferrin is an iron-binding protein present in large quantities in colostrum and in breast milk, in external secretions and in polymorphonuclear leukocytes. Lactoferrin’s main function is non-immune protection. Among several protective activities shown by lactoferrin, those displayed by orally administered lactoferrin are: (i) antimicrobial activity, which has been presumed due to iron ... ... hiện toàn bộ
Tập 9 Số 4 - Trang 61
Therapeutic Drug Monitoring of the Newer Anti-Epilepsy MedicationsIn the past twenty years, 14 new antiepileptic drugs have been approved for use in the United States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide. In general, the clinical utility of therapeutic drug monitoring has no... ... hiện toàn bộ
Tập 3 Số 6 - Trang 1909-1935
Opioid Analgesia and Opioid-Induced Adverse Effects: A ReviewOpioids are widely used as therapeutic agents against moderate to severe acute and chronic pain. Still, these classes of analgesic drugs have many potential limitations as they induce analgesic tolerance, addiction and numerous behavioural adverse effects that often result in patient non-compliance. As opium and opioids have been traditionally used as painkillers, the exact mechanisms of t... ... hiện toàn bộ
Tập 14 Số 11 - Trang 1091
A Review of Therapeutic Aptamer Conjugates with Emphasis on New ApproachesThe potential to emulate or enhance antibodies with nucleic acid aptamers while lowering costs has prompted development of new aptamer-protein, siRNA, drug, and nanoparticle conjugates. Specific focal points of this review discuss DNA aptamers covalently bound at their 3' ends to various proteins for enhanced stability and greater pharmacokinetic lifetimes in vivo. The proteins can include... ... hiện toàn bộ
Tập 6 Số 3 - Trang 340-357