Pharmaceuticals
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Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection
Pharmaceuticals - Tập 10 Số 4 - Trang 83
Traumatic spinal cord injury (SCI) causes dramatic disability and dysfunction in
the motor, sensory and autonomic systems. The severe inflammatory reaction that
occurs after SCI is strongly associated with further tissue damage. As such,
immunomodulatory strategies have been developed, aimed at reducing inflammation,
but also at shaping the immune response in order to protect, repair and promote
r...
Endolysosomal Cation Channels and Cancer—A Link with Great Potential
Pharmaceuticals - Tập 11 Số 1 - Trang 4
The endolysosomal system (ES) consists of lysosomes; early, late, and recycling
endosomes; and autophagosomes. It is a key regulator not only of macromolecule
degradation and recycling, plasma membrane repair, homeostasis, and lipid
storage, but also of antigen presentation, immune defense, cell motility, cell
death signaling, tumor growth, and cancer progression. In addition, it plays a
critical ...
Norethindrone Acetate in the Medical Management of Adenomyosis
Pharmaceuticals - Tập 5 Số 10 - Trang 1120-1127
The role of norethindrone acetate (NA) in the management of adenomyosis was
evaluated with a retrospective chart review of 28 premenopausal women between
27–49 years of age presenting with moderate to severe pelvic pain and bleeding.
Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was
significant improvement of both dysmenorrhea and bleeding after treatment. Age
showed n...
A Review of Therapeutic Aptamer Conjugates with Emphasis on New Approaches
Pharmaceuticals - Tập 6 Số 3 - Trang 340-357
The potential to emulate or enhance antibodies with nucleic acid aptamers while
lowering costs has prompted development of new aptamer-protein, siRNA, drug, and
nanoparticle conjugates. Specific focal points of this review discuss DNA
aptamers covalently bound at their 3' ends to various proteins for enhanced
stability and greater pharmacokinetic lifetimes in vivo. The proteins can
include Fc tail...
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
Pharmaceuticals - Tập 6 Số 1 - Trang 85-107
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for
post-transcriptional regulation of gene expression. Although RNAi therapeutics
have recently progressed through the pipeline toward clinical trials, the
application of these as ideal, clinical therapeutics requires the development of
safe and effective delivery systems. Inspired by the immense progress with
nanotechnolo...
Antimicrobial Peptides from Fish
Pharmaceuticals - Tập 7 Số 3 - Trang 265-310
Antimicrobial peptides (AMPs) are found widely distributed through Nature, and
participate in the innate host defense of each species. Fish are a great source
of these peptides, as they express all of the major classes of AMPs, including
defensins, cathelicidins, hepcidins, histone-derived peptides, and a
fish-specific class of the cecropin family, called piscidins. As with other
species, the fish...
Conformational Analysis, Molecular Structure and Solid State Simulation of the Antiviral Drug Acyclovir (Zovirax) Using Density Functional Theory Methods
Pharmaceuticals - Tập 7 Số 6 - Trang 695-722
The five tautomers of the drug acyclovir (ACV) were determined and optimised at
the MP2 and B3LYP quantum chemical levels of theory. The stability of the
tautomers was correlated with different parameters. On the most stable tautomer
N1 was carried out a comprehensive conformational analysis, and the whole
conformational parameters (R, β, Φ, φ1, φ2, φ3, φ4, φ5) were studied as well as
the NBO Natu...
SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
Pharmaceuticals - Tập 14 Số 3 - Trang 216
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic
reactions that are reprogramed and upregulated in cancer; these pathways are
involved in supporting the growth and proliferation of cancer cells.
Glutaminolysis participates in the production of lactate, an oncometabolite, and
also in anabolic reactions leading to the synthesis of fatty acids and
cholesterol. The serine–...
Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis
Pharmaceuticals - Tập 12 Số 1 - Trang 26
Ferroptosis is a form of programmed cell death that is characterized by lipid
peroxidation and is inducible by iron and the accumulation of reactive oxygen
species (ROS). It is triggered by erastin but inhibited by antioxidants such as
α-tocopherol, β-carotene, polyphenols, and iron chelators such as deferoxamine
(DFO), nitrilotriacetic acid (NTA), and ethylenediaminetetraacetic acid (EDTA).
This ...
Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways
Pharmaceuticals - Tập 13 Số 11 - Trang 348
Treatment of breast cancer with doxorubicin causes numerous side effects, of
which cardiac fibrosis is considered the main one. This study was designed to
investigate the underlying molecular mechanisms for the potential anti-fibrotic
effect of pirfenidone and vitamin D against doxorubicin-induced cardiac
fibrosis. Seventy mice carrying solid Ehrlich’s ascites carcinoma (EAC) discs on
the ventral ...
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