Pharmaceuticals

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Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection
Pharmaceuticals - Tập 10 Số 4 - Trang 83
Rui Lima, Susana Monteiro, José Manuel Lopes, Pedro Barradas, Natália Vasconcelos, Eduardo D. Gomes, Rita C. Assunção-Silva, Fábio G. Teixeira, Mónica Morais, Nuno Sousa, António J. Salgado, Nuno A. Silva
Traumatic spinal cord injury (SCI) causes dramatic disability and dysfunction in the motor, sensory and autonomic systems. The severe inflammatory reaction that occurs after SCI is strongly associated with further tissue damage. As such, immunomodulatory strategies have been developed, aimed at reducing inflammation, but also at shaping the immune response in order to protect, repair and p...... hiện toàn bộ
Endolysosomal Cation Channels and Cancer—A Link with Great Potential
Pharmaceuticals - Tập 11 Số 1 - Trang 4
Christian Grimm, Karin Bartel, Angelika M. Vollmar, Martin Biel
The endolysosomal system (ES) consists of lysosomes; early, late, and recycling endosomes; and autophagosomes. It is a key regulator not only of macromolecule degradation and recycling, plasma membrane repair, homeostasis, and lipid storage, but also of antigen presentation, immune defense, cell motility, cell death signaling, tumor growth, and cancer progression. In addition, it plays a c...... hiện toàn bộ
Norethindrone Acetate in the Medical Management of Adenomyosis
Pharmaceuticals - Tập 5 Số 10 - Trang 1120-1127
Ozgul Muneyyirci‐Delale, Ashadeep Chandrareddy, Siddhi Mankame, N. Osei-Tutu, Hans von Gizycki
The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was significant improvement of both dysmenorrhea and bleeding after treatment. Age ...... hiện toàn bộ
A Review of Therapeutic Aptamer Conjugates with Emphasis on New Approaches
Pharmaceuticals - Tập 6 Số 3 - Trang 340-357
John G. Bruno
The potential to emulate or enhance antibodies with nucleic acid aptamers while lowering costs has prompted development of new aptamer-protein, siRNA, drug, and nanoparticle conjugates. Specific focal points of this review discuss DNA aptamers covalently bound at their 3' ends to various proteins for enhanced stability and greater pharmacokinetic lifetimes in vivo. The proteins can include...... hiện toàn bộ
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
Pharmaceuticals - Tập 6 Số 1 - Trang 85-107
Jiehua Zhou, Ka To Shum, John Burnett, John J. Rossi
RNA interference (RNAi) is an evolutionarily conserved, endogenous process for post-transcriptional regulation of gene expression. Although RNAi therapeutics have recently progressed through the pipeline toward clinical trials, the application of these as ideal, clinical therapeutics requires the development of safe and effective delivery systems. Inspired by the immense progress with nano...... hiện toàn bộ
Antimicrobial Peptides from Fish
Pharmaceuticals - Tập 7 Số 3 - Trang 265-310
Jorge A. Masso-Silva, Gill Diamond
Antimicrobial peptides (AMPs) are found widely distributed through Nature, and participate in the innate host defense of each species. Fish are a great source of these peptides, as they express all of the major classes of AMPs, including defensins, cathelicidins, hepcidins, histone-derived peptides, and a fish-specific class of the cecropin family, called piscidins. As with other species...... hiện toàn bộ
Conformational Analysis, Molecular Structure and Solid State Simulation of the Antiviral Drug Acyclovir (Zovirax) Using Density Functional Theory Methods
Pharmaceuticals - Tập 7 Số 6 - Trang 695-722
M.C. Álvarez-Ros, M. Alcolea Palafox
The five tautomers of the drug acyclovir (ACV) were determined and optimised at the MP2 and B3LYP quantum chemical levels of theory. The stability of the tautomers was correlated with different parameters. On the most stable tautomer N1 was carried out a comprehensive conformational analysis, and the whole conformational parameters (R, β, Φ, φ1, φ2, φ3, φ4, φ5) were studied as well as the ...... hiện toàn bộ
SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
Pharmaceuticals - Tập 14 Số 3 - Trang 216
Tyler Sniegowski, Ksenija Korać, Yangzom D. Bhutia, Vadivel Ganapathy
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions that are reprogramed and upregulated in cancer; these pathways are involved in supporting the growth and proliferation of cancer cells. Glutaminolysis participates in the production of lactate, an oncometabolite, and also in anabolic reactions leading to the synthesis of fatty acids and cholesterol. The...... hiện toàn bộ
Curcumin and (−)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells against Iron Toxicity and Erastin-Induced Ferroptosis
Pharmaceuticals - Tập 12 Số 1 - Trang 26
Tugba Kose, Mayra Vera-Aviles, Paul Sharp, Gladys O. Latunde‐Dada
Ferroptosis is a form of programmed cell death that is characterized by lipid peroxidation and is inducible by iron and the accumulation of reactive oxygen species (ROS). It is triggered by erastin but inhibited by antioxidants such as α-tocopherol, β-carotene, polyphenols, and iron chelators such as deferoxamine (DFO), nitrilotriacetic acid (NTA), and ethylenediaminetetraacetic acid (EDTA...... hiện toàn bộ
Pirfenidone and Vitamin D Ameliorate Cardiac Fibrosis Induced by Doxorubicin in Ehrlich Ascites Carcinoma Bearing Mice: Modulation of Monocyte Chemoattractant Protein-1 and Jun N-terminal Kinase-1 Pathways
Pharmaceuticals - Tập 13 Số 11 - Trang 348
Mohamed A. Saleh, Samar A. Antar, Reem M. Hazem, Mona F. El-Azab
Treatment of breast cancer with doxorubicin causes numerous side effects, of which cardiac fibrosis is considered the main one. This study was designed to investigate the underlying molecular mechanisms for the potential anti-fibrotic effect of pirfenidone and vitamin D against doxorubicin-induced cardiac fibrosis. Seventy mice carrying solid Ehrlich’s ascites carcinoma (EAC) discs on the ...... hiện toàn bộ
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