Pharmaceuticals

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Endolysosomal Cation Channels and Cancer—A Link with Great Potential
Pharmaceuticals - Tập 11 Số 1 - Trang 4
Christian Grimm, Karin Bartel, Angelika M. Vollmar, Martin Biel
The endolysosomal system (ES) consists of lysosomes; early, late, and recycling endosomes; and autophagosomes. It is a key regulator not only of macromolecule degradation and recycling, plasma membrane repair, homeostasis, and lipid storage, but also of antigen presentation, immune defense, cell motility, cell death signaling, tumor growth, and cancer progression. In addition, it plays a c...... hiện toàn bộ
Conformational Analysis, Molecular Structure and Solid State Simulation of the Antiviral Drug Acyclovir (Zovirax) Using Density Functional Theory Methods
Pharmaceuticals - Tập 7 Số 6 - Trang 695-722
M.C. Álvarez-Ros, M. Alcolea Palafox
The five tautomers of the drug acyclovir (ACV) were determined and optimised at the MP2 and B3LYP quantum chemical levels of theory. The stability of the tautomers was correlated with different parameters. On the most stable tautomer N1 was carried out a comprehensive conformational analysis, and the whole conformational parameters (R, β, Φ, φ1, φ2, φ3, φ4, φ5) were studied as well as the ...... hiện toàn bộ
SLC6A14 and SLC38A5 Drive the Glutaminolysis and Serine–Glycine–One-Carbon Pathways in Cancer
Pharmaceuticals - Tập 14 Số 3 - Trang 216
Tyler Sniegowski, Ksenija Korać, Yangzom D. Bhutia, Vadivel Ganapathy
The glutaminolysis and serine–glycine–one-carbon pathways represent metabolic reactions that are reprogramed and upregulated in cancer; these pathways are involved in supporting the growth and proliferation of cancer cells. Glutaminolysis participates in the production of lactate, an oncometabolite, and also in anabolic reactions leading to the synthesis of fatty acids and cholesterol. The...... hiện toàn bộ
Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches
Pharmaceuticals - Tập 13 Số 8 - Trang 183
Tahmina Akter Bristy, Niloy Barua, Abu Montakim Tareq, Shahenur Alam Sakib, Saida Tasnim Etu, Kamrul Hasan Chowdhury, Mifta Ahmed Jyoti, Md. Arfin Ibn Aziz, A.S.M. Ali Reza, Elisabetta Caiazzo, Barbara Romano, Syed Mohammed Tareq, Talha Bin Emran, Raffaele Capasso
The present study explores the neuropharmacological, antinociceptive, antidiarrheal, antioxidant, thrombolytic and cytotoxic activity of methanol extract of Psychotria calocarpa leaves (MEPC). In anxiolytic activity testing of MEPC by elevated plus maze test, hole–board test and light–dark test, the extract exhibited a dose-dependent reduction of anxiety while the open field test observed ...... hiện toàn bộ
The Inhibition of Stat5 by a Peptide Aptamer Ligand Specific for the DNA Binding Domain Prevents Target Gene Transactivation and the Growth of Breast and Prostate Tumor Cells
Pharmaceuticals - Tập 6 Số 8 - Trang 960-987
Axel Weber, Corina Borghouts, Christian Brendel, Richard Moriggl, Natalia Delis, Boris Brill, Vida Vafaizadeh, Bernd Groner
The signal transducer and activator of transcription Stat5 is transiently activated by growth factor and cytokine signals in normal cells, but its persistent activation has been observed in a wide range of human tumors. Aberrant Stat5 activity was initially observed in leukemias, but subsequently also found in carcinomas. We investigated the importance of Stat5 in human tumor cell lines. s...... hiện toàn bộ
A Review of Ten Years of the Study for Monitoring Antimicrobial Resistance Trends (SMART) from 2002 to 2011
Pharmaceuticals - Tập 6 Số 11 - Trang 1335-1346
Ian Morrissey, Meredith Hackel, Robert E. Badal, Samuel K. Bouchillon, Stephen Hawser, Douglas J. Biedenbach
Surveillance of antimicrobial agent resistance provides important information to guide microbiologists and infectious disease specialists understanding of the control and the spread of resistance mechanisms within the local environment. Continued monitoring of antimicrobial resistance patterns in the community and in local hospital environments is essential to guide effective empiric thera...... hiện toàn bộ
Therapeutic Drug Monitoring of the Newer Anti-Epilepsy Medications
Pharmaceuticals - Tập 3 Số 6 - Trang 1909-1935
Matthew D. Krasowski
In the past twenty years, 14 new antiepileptic drugs have been approved for use in the United States and/or Europe. These drugs are eslicarbazepine acetate, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, pregabalin, rufinamide, stiripentol, tiagabine, topiramate, vigabatrin and zonisamide. In general, the clinical utility of therapeutic drug monitoring has no...... hiện toàn bộ
Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor
Pharmaceuticals - Tập 15 Số 1 - Trang 3
William M. Pardridge
Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier (BBB), which is formed by the brain capillary endothelium. Biologics can be re-engineered for BBB transport as IgG fusion proteins, where the IgG domain is a monoclonal antibody (MAb) that targets an endogenous BBB transporter, such as the insulin receptor (IR) or transferrin receptor (TfR). The IR ...... hiện toàn bộ
Lactoferrin and Its Potential Impact for the Relief of Pain: A Preclinical Approach
Pharmaceuticals - Tập 14 Số 9 - Trang 868
Beatriz Godínez‐Chaparro, Fabiola Guzmán-Mejía, María Elisa Drago-Serrano
Pain is one of the most disabling symptoms of several clinical conditions. Neurobiologically, it is classified as nociceptive, inflammatory, neuropathic and dysfunctional. Opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) are conventionally prescribed for the treatment of pain. Long-term administration of opioids results in the loss of analgesic efficacy, leading to increased dosag...... hiện toàn bộ
Targeting MMP-9 in Diabetic Foot Ulcers
Pharmaceuticals - Tập 12 Số 2 - Trang 79
Jeffrey I. Jones, Trung T. Nguyen, Zhihong Peng, Mayland Chang
Diabetic foot ulcers (DFUs) are significant complications of diabetes and an unmet medical need. Matrix metalloproteinases (MMPs) play important roles in the pathology of wounds and in the wound healing process. However, because of the challenge in distinguishing active MMPs from the two catalytically inactive forms of MMPs and the clinical failure of broad-spectrum MMP inhibitors in cance...... hiện toàn bộ
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