Norethindrone Acetate in the Medical Management of Adenomyosis

Pharmaceuticals - Tập 5 Số 10 - Trang 1120-1127
Ozgul Muneyyirci‐Delale1,2, Ashadeep Chandrareddy2, Siddhi Mankame2, N. Osei-Tutu2, Hans von Gizycki3
1Department of Obstetrics and Gynecology, Kings County Hospital Center, 451 Clarkson Avenue, Brooklyn, NY 11203, USA
2Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
3Scientific Computing Center, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA

Tóm tắt

The role of norethindrone acetate (NA) in the management of adenomyosis was evaluated with a retrospective chart review of 28 premenopausal women between 27–49 years of age presenting with moderate to severe pelvic pain and bleeding. Bleeding and dysmenorrhea scores were analyzed using paired T-tests. There was significant improvement of both dysmenorrhea and bleeding after treatment. Age showed no correlation with dysmenorrhea or bleeding. Low dose NA could be considered an effective, well-tolerated and inexpensive medical alternative to surgery for treating symptomatic adenomyosis. Large multicentric studies may help validate our findings.

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